What maximizes the effectiveness and implementation of technology-based interventions to support healthcare professional practice? A systematic literature review

BackgroundTechnological support may be crucial in optimizing healthcare professional practice and improving patient outcomes. A focus on electronic health records has left other technological supports relatively neglected. Additionally, there has been no comparison between different types of technology-based interventions, and the importance of delivery setting on the implementation of technology-based interventions to change professional practice. Consequently, there is a need to synthesise and examine intervention characteristics using a methodology suited to identifying important features of effective interventions, and the barriers and facilitators to implementation. Three aims were addressed: to identify interventions with a technological component that are successful at changing professional practice, to determine if and how such interventions are theory-based, and to examine barriers and facilitators to successful implementation.MethodsA literature review informed by realist review methods was conducted involving a systematic search of studies reporting either: (1) behavior change interventions that included technology to support professional practice change; or (2) barriers and facilitators to implementation of technological interventions. Extracted data was quantitative and qualitative, and included setting, target professionals, and use of Behaviour Change Techniques (BCTs). The primary outcome was a change in professional practice. A thematic analysis was conducted on studies reporting barriers and facilitators of implementation.ResultsSixty-nine studies met the inclusion criteria; 48 (27 randomized controlled trials) reported behavior change interventions and 21 reported practicalities of implementation. The most successful technological intervention was decision support providing healthcare professionals with knowledge and/or person-specific information to assist with patient management. Successful technologies were more likely to operationalise BCTs, particularly “instruction on how to perform the behavior”. Facilitators of implementation included aligning studies with organisational initiatives, ensuring senior peer endorsement, and integration into clinical workload. Barriers included organisational challenges, and design, content and technical issues of technology-based interventions.ConclusionsTechnological interventions must focus on providing decision support for clinical practice using recognized behavior change techniques. Interventions must consider organizational context, clinical workload, and have clearly defined benefits for improving practice and patient outcomes.

[1]  Trisha Greenhalgh,et al.  Protocol - realist and meta-narrative evidence synthesis: Evolving Standards (RAMESES) , 2011, BMC medical research methodology.

[2]  Mae Keary,et al.  The Science of Evaluation: A Realist Manifesto , 2014, Online Inf. Rev..

[3]  Charlene R. Weir,et al.  The role of information technology in translating educational interventions into practice: an analysis using the PRECEDE/PROCEED model , 2011, J. Am. Medical Informatics Assoc..

[4]  C. McCulloch,et al.  A cluster randomized trial of decision support strategies for reducing antibiotic use in acute bronchitis. , 2013, JAMA internal medicine.

[5]  Thomas Babor,et al.  Improving Pediatric Asthma Control Among Minority Children Participating in Medicaid: Providing Practice Redesign Support to Deliver a Chronic Care Model , 2010, The Journal of asthma : official journal of the Association for the Care of Asthma.

[6]  J. Wyatt,et al.  Computer-generated reminders delivered on paper to healthcare professionals; effects on professional practice and health care outcomes. , 2017, The Cochrane database of systematic reviews.

[7]  Inês Ribeiro-Vaz,et al.  Promoting Spontaneous Adverse Drug Reaction Reporting in Hospitals Using a Hyperlink to the Online Reporting Form , 2012, Drug Safety.

[8]  Josip Car,et al.  Email for clinical communication between healthcare professionals. , 2015, The Cochrane database of systematic reviews.

[9]  Cara B. Litvin,et al.  Adoption of a clinical decision support system to promote judicious use of antibiotics for acute respiratory infections in primary care , 2012, Int. J. Medical Informatics.

[10]  S. Marcus,et al.  Training and consultation to promote implementation of an empirically supported treatment: a randomized trial. , 2012, Psychiatric services.

[11]  T Lauritzen,et al.  Improved quality of Type 2 diabetes care following electronic feedback of treatment status to general practitioners: a cluster randomized controlled trial , 2010, Diabetic medicine : a journal of the British Diabetic Association.

[12]  D. Malone,et al.  Evaluation of a Wireless Handheld Medication Management Device in the Prevention of Drug-Drug Interactions in a Medicaid Population , 2012, Journal of managed care pharmacy : JMCP.

[13]  Carl R May,et al.  Promoting professional behaviour change in healthcare: what interventions work, and why? A theory-led overview of systematic reviews , 2015, BMJ Open.

[14]  Kristi Jackson,et al.  Qualitative Data Analysis with NVivo , 2007 .

[15]  D. Mant Health checks and screening: what works in general practice? , 2014, The British journal of general practice : the journal of the Royal College of General Practitioners.

[16]  M. Johnston,et al.  Effectiveness of strategies to disseminate and implement clinical guidelines for the management of impacted and unerupted third molars in primary dental care, a cluster randomised controlled trial , 2004, British Dental Journal.

[17]  Julie M. Skutch,et al.  Which training method works best? A randomized controlled trial comparing three methods of training clinicians in dialectical behavior therapy skills. , 2009, Behaviour research and therapy.

[18]  Miriam C.J.M. Sturkenboom,et al.  Electronic Alerts Versus On-Demand Decision Support to Improve Dyslipidemia Treatment: A Cluster Randomized Controlled Trial , 2008, Circulation.

[19]  P. Tugwell,et al.  Interventions to increase the use of electronic health information by healthcare practitioners to improve clinical practice and patient outcomes. , 2015, The Cochrane database of systematic reviews.

[20]  F. Barg,et al.  Feasibility and effects of a Web-based adolescent psychiatric assessment administered by clinical staff in the pediatric emergency department. , 2010, Archives of pediatrics & adolescent medicine.

[21]  A. Tricco,et al.  What is the most appropriate knowledge synthesis method to conduct a review? Protocol for a scoping review , 2012, BMC Medical Research Methodology.

[22]  J. Grimshaw,et al.  Explaining clinical behaviors using multiple theoretical models , 2012, Implementation Science.

[23]  Gill Harvey,et al.  Understanding the implementation of interventions to improve the management of chronic kidney disease in primary care: a rapid realist review , 2015, Implementation Science.

[24]  E. Taveras,et al.  Provider Perspectives on Electronic Decision Supports for Obesity Prevention , 2012, Clinical pediatrics.

[25]  S. Ornstein,et al.  Use of an Electronic Health Record Clinical Decision Support Tool to Improve Antibiotic Prescribing for Acute Respiratory Infections: The ABX-TRIP Study , 2013, Journal of General Internal Medicine.

[26]  M J Lincoln,et al.  A computer-generated reminder system improves physician compliance with diabetes preventive care guidelines. , 1995, Proceedings. Symposium on Computer Applications in Medical Care.

[27]  Sallie-Anne Pearson,et al.  Standardizing care in medical oncology , 2009, Cancer.

[28]  C. Dowrick,et al.  Complex interventions , 2022, International Review of Sport and Exercise Psychology.

[29]  Edward P. Armstrong,et al.  Evaluation of a drug-drug interaction: fax alert intervention program , 2013, BMC Medical Informatics and Decision Making.

[30]  Siobhan M. Dolan,et al.  Evaluation of a Novel Electronic Genetic Screening and Clinical Decision Support Tool in Prenatal Clinical Settings , 2014, Maternal and Child Health Journal.

[31]  S. Michie,et al.  The behaviour change wheel: A new method for characterising and designing behaviour change interventions , 2011, Implementation science : IS.

[32]  Megan Doerr,et al.  Formative Evaluation of Clinician Experience with Integrating Family History-Based Clinical Decision Support into Clinical Practice , 2014, Journal of personalized medicine.

[33]  J. Grimshaw,et al.  Practice based, longitudinal, qualitative interview study of computerised evidence based guidelines in primary care , 2003, BMJ : British Medical Journal.

[34]  D. Cardo,et al.  Impact of Different Methods of Feedback to Clinicians After Postprescription Antimicrobial Review Based on the Centers for Disease Control and Prevention's 12 Steps to Prevent Antimicrobial Resistance Among Hospitalized Adults , 2007, Infection Control & Hospital Epidemiology.

[35]  F. Haaijer-Ruskamp,et al.  The Additional Value of an E-Mail to Inform Healthcare Professionals of a Drug Safety Issue: A Randomized Controlled Trial in the Netherlands , 2013, Drug Safety.

[36]  N. Kearney,et al.  Nurse's perceptions and experiences of using of a mobile-phone-based Advanced Symptom Management System (ASyMS) to monitor and manage chemotherapy-related toxicity. , 2008, European journal of oncology nursing : the official journal of European Oncology Nursing Society.

[37]  Isaac Hoch,et al.  Application of Information Technology: Countrywide Computer Alerts to Community Physicians Improve Potassium Testing in Patients Receiving Diuretics , 2003, J. Am. Medical Informatics Assoc..

[38]  I. Kunnamo,et al.  Patient-specific computer-based decision support in primary healthcare—a randomized trial , 2014, Implementation Science.

[39]  J. Reeve,et al.  An electronic prompt in dispensing software to promote clinical interventions by community pharmacists: a randomized controlled trial. , 2008, British journal of clinical pharmacology.

[40]  Tarja Heponiemi,et al.  Reflective and Automatic Processes in Health Care Professional Behaviour: a Dual Process Model Tested Across Multiple Behaviours , 2014, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[41]  Mona Sharifi,et al.  Enhancing the electronic health record to increase counseling and quit-line referral for parents who smoke. , 2014, Academic pediatrics.

[42]  Sarah P. Slight,et al.  A systematic review of the types and causes of prescribing errors generated from using computerized provider order entry systems in primary and secondary care , 2017, AMIA.

[43]  Reed M. Gardner,et al.  Clinicians' Response to Computerized Detection of Infections , 1998, AMIA.

[44]  C. Abraham,et al.  Effective techniques in healthy eating and physical activity interventions: a meta-regression. , 2009, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[45]  M. Laurant,et al.  Factors associated with the impact of quality improvement collaboratives in mental healthcare: An exploratory study , 2012, Implementation Science.

[46]  D. Webb,et al.  Perceived causes of prescribing errors by junior doctors in hospital inpatients: a study from the PROTECT programme , 2012, BMJ quality & safety.

[47]  S. Michie,et al.  Using realist review to inform intervention development: methodological illustration and conceptual platform for collaborative care in offender mental health , 2015, Implementation Science.

[48]  Jeffrey R Curtis,et al.  Challenges in improving the quality of osteoporosis care for long-term glucocorticoid users: a prospective randomized trial. , 2007, Archives of internal medicine.

[49]  David Parkin,et al.  Effect of computerised evidence based guidelines on management of asthma and angina in adults in primary care: cluster randomised controlled trial , 2002, BMJ : British Medical Journal.

[50]  S. Bakken,et al.  Clinical Practice Guideline Adherence Before and After Implementation of the HEARTFELT (HEART Failure Effectiveness & Leadership Team) Intervention , 2005, The Journal of cardiovascular nursing.

[51]  M. Landre,et al.  Assessment of radiological referral practice and effect of computer-based guidelines on radiological requests in two emergency departments. , 2002, Clinical radiology.

[52]  Alessandro Filippi,et al.  Effects of an automated electronic reminder in changing the antiplatelet drug-prescribing behavior among Italian general practitioners in diabetic patients: an intervention trial. , 2003, Diabetes care.

[53]  J. Grimshaw,et al.  An intervention modelling experiment to change GPs' intentions to implement evidence-based practice: using theory-based interventions to promote GP management of upper respiratory tract infection without prescribing antibiotics #2 , 2008, BMC Health Services Research.

[54]  Ann Van Hecke,et al.  A multi-faceted tailored strategy to implement an electronic clinical decision support system for pressure ulcer prevention in nursing homes: a two-armed randomized controlled trial. , 2013, International journal of nursing studies.

[55]  C. Abraham,et al.  Implementing health promotion programmes in schools: a realist systematic review of research and experience in the United Kingdom , 2015, Implementation Science.

[56]  M. Cowie National Institute for Health and Care Excellence. , 2015, European heart journal.

[57]  M. Eccles,et al.  Welcome to Implementation Science , 2006, Implementation Science.

[58]  J. Rethans,et al.  Controlled trial of effect of computer-based nutrition course on knowledge and practice of general practitioner trainees. , 2003, The American journal of clinical nutrition.

[59]  A. Localio,et al.  Effect of decision support on missed opportunities for human papillomavirus vaccination. , 2014, American journal of preventive medicine.

[60]  J. Popay,et al.  Systematically reviewing qualitative and quantitative evidence to inform management and policy-making in the health field , 2005, Journal of health services research & policy.

[61]  James J. Cimino,et al.  Clinicians′ evaluation of computer-assisted medication summarization of electronic medical records , 2015, Comput. Biol. Medicine.

[62]  Maria Lucia Specchia,et al.  The impact of electronic health records on healthcare quality: a systematic review and meta-analysis. , 2016, European journal of public health.

[63]  E. Denney-Wilson,et al.  Influence of cardiovascular absolute risk assessment on prescribing of antihypertensive and lipid-lowering medications: a cluster randomized controlled trial. , 2014, American heart journal.

[64]  J. Fox,et al.  Evidence-based guidelines and decision support services: a discussion and evaluation in triple assessment of suspected breast cancer , 2006, British Journal of Cancer.

[65]  Mark W. Lipsey,et al.  Practical Meta-Analysis , 2000 .

[66]  Ramin Khorasani,et al.  Effect of clinical decision support on documented guideline adherence for head CT in emergency department patients with mild traumatic brain injury. , 2014, Journal of the American Medical Informatics Association : JAMIA.

[67]  Eleanor Bimla Schwarz,et al.  Clinical Decision Support to Promote Safe Prescribing to Women of Reproductive Age: A Cluster-Randomized Trial , 2012, Journal of General Internal Medicine.

[68]  J. Hocking,et al.  Computer Reminders for Chlamydia Screening in General Practice: A Randomized Controlled Trial , 2010, Sexually transmitted diseases.

[69]  M. Jeyaraman,et al.  Behavior change interventions and policies influencing primary healthcare professionals’ practice—an overview of reviews , 2017, Implementation Science.

[70]  Julie Barnett,et al.  myPace: An Integrative Health Platform for Supporting Weight Loss and Maintenance Behaviors , 2015, IEEE Journal of Biomedical and Health Informatics.

[71]  Kaveh G Shojania,et al.  Effect of point-of-care computer reminders on physician behaviour: a systematic review , 2010, Canadian Medical Association Journal.

[72]  Steven M. Asch,et al.  Central Implementation Strategies Outperform Local Ones in Improving HIV Testing in Veterans Healthcare Administration Facilities , 2013, Journal of General Internal Medicine.

[73]  M. Petticrew,et al.  Developing and evaluating complex interventions: the new Medical Research Council guidance , 2008, BMJ : British Medical Journal.

[74]  Andrew Dalley,et al.  The introduction of electronic medication charts and prescribing in aged care facilities: An evaluation , 2007 .

[75]  C. Dowrick,et al.  Implementation Science Development of a Theory of Implementation and Integration: Normalization Process Theory , 2022 .

[76]  Jo Rycroft-Malone,et al.  Realist synthesis: illustrating the method for implementation research , 2012, Implementation Science.

[77]  Michael S. Leonard,et al.  Patterns and changes in prescriber attitudes toward PDA prescription-assistive technology , 2009, Int. J. Medical Informatics.

[78]  Irene Pala,et al.  BMC Medical Informatics and Decision Making , 2014, BMC Medical Informatics and Decision Making.

[79]  Catherine Pope,et al.  Assessing the implementability of telehealth interventions for self-management support: a realist review , 2015, Implementation Science.

[80]  A. Sheikh,et al.  A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis , 2012, The Lancet.

[81]  R. Lau,et al.  Factors that influence the implementation of e-health: a systematic review of systematic reviews (an update) , 2016, Implementation Science.

[82]  F D Hobbs,et al.  A prospective controlled trial of computerized decision support for lipid management in primary care. , 1996, Family practice.

[83]  K. Payne,et al.  Prevention and lifestyle behaviour change : a competence framework , 2010 .

[84]  Mohan M. Nadkarni,et al.  Improving Smoking Cessation Counseling Using a Point-of-Care Health Intervention Tool (IT): From the Virginia Practice Support and Research Network (VaPSRN) , 2013, The Journal of the American Board of Family Medicine.

[85]  K. Shojania,et al.  The effects of on-screen, point of care computer reminders on processes and outcomes of care. , 2009, The Cochrane database of systematic reviews.

[86]  Steven R. Simon,et al.  Reducing the Prescribing of Heavily Marketed Medications: A Randomized Controlled Trial , 2009, Journal of General Internal Medicine.

[87]  Jacob Cohen Statistical Power Analysis for the Behavioral Sciences , 1969, The SAGE Encyclopedia of Research Design.

[88]  Vibeke Zoffmann,et al.  Suboptimal quality of type 2 diabetes care discovered through electronic feedback led to increased nurse-GP cooperation. A qualitative study. , 2010, Primary care diabetes.

[89]  Charles E. Leonard,et al.  Unintended effects of a computerized physician order entry nearly hard-stop alert to prevent a drug interaction: a randomized controlled trial. , 2010, Archives of internal medicine.

[90]  Cornelia M. Ruland,et al.  Research Paper: Handheld Technology to Improve Patient Care: Evaluating a Support System for Preference-based Care Planning at the Bedside , 2002, J. Am. Medical Informatics Assoc..

[91]  J. Metlay,et al.  One size does not fit all: evaluating an intervention to reduce antibiotic prescribing for acute bronchitis , 2013, BMC Health Services Research.

[92]  S. Asch,et al.  The role of evidence and context for implementing a multimodal intervention to increase HIV testing , 2015, Implementation Science.

[93]  J. Staves,et al.  The impact of electronic decision support and electronic remote blood issue on transfusion practice , 2014, Transfusion medicine.

[94]  C. Abraham,et al.  The Behavior Change Technique Taxonomy (v1) of 93 Hierarchically Clustered Techniques: Building an International Consensus for the Reporting of Behavior Change Interventions , 2013, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[95]  C. McDonald,et al.  Effects of computerized guidelines for managing heart disease in primary care , 2003, Journal of General Internal Medicine.

[96]  Steven M. Asch,et al.  A System-wide Intervention to Improve HIV Testing in the Veterans Health Administration , 2008, Journal of General Internal Medicine.

[97]  Craig Whittington,et al.  Using theory to synthesise evidence from behaviour change interventions: the example of audit and feedback. , 2010, Social science & medicine.

[98]  J. Grimshaw,et al.  Changing the behavior of healthcare professionals: the use of theory in promoting the uptake of research findings. , 2005, Journal of clinical epidemiology.

[99]  Paul C. Tang,et al.  Research Paper: Measuring the Effects of Reminders for Outpatient Influenza Immunizations at the Point of Clinical Opportunity , 1999, J. Am. Medical Informatics Assoc..

[100]  Rebecca Randell,et al.  Nurses' use of computerised clinical decision support systems: a case site analysis. , 2009, Journal of clinical nursing.

[101]  T. Dornan,et al.  Prevalence, Nature, Severity and Risk Factors for Prescribing Errors in Hospital Inpatients: Prospective Study in 20 UK Hospitals , 2015, Drug Safety.

[102]  Louis M Bell,et al.  Effect of an outpatient antimicrobial stewardship intervention on broad-spectrum antibiotic prescribing by primary care pediatricians: a randomized trial. , 2013, JAMA.

[103]  Samhandling mellom allmennleger og apotek ved korreksjon av resepter , 2009 .

[104]  Emily S. Patterson,et al.  Exploring barriers and facilitators to the use of computerized clinical reminders. , 2005, Journal of the American Medical Informatics Association : JAMIA.

[105]  Rebecca Randell,et al.  Organisational Influences on Nurses' Use of Clinical Decision Support Systems Senior Lecturer in Clinical Decision Making , 2014 .

[106]  Emily S. Patterson,et al.  Research Paper: Human Factors Barriers to the Effective Use of Ten HIV Clinical Reminders , 2004, J. Am. Medical Informatics Assoc..

[107]  T. Greenhalgh,et al.  Realist review - a new method of systematic review designed for complex policy interventions , 2005, Journal of health services research & policy.

[108]  W. Hammond,et al.  Computerized decision support based on a clinical practice guideline improves compliance with care standards. , 1997, The American journal of medicine.