Bilateral interaction in the second somatosensory area (SII) of the cat and contribution of the corpus callosum

There are indications in the literature that convergent ipsilateral and contralateral input to the second somatosensory area (SII) may interact. Single unit activity of SII bilateral cells was studied to evaluate the impact of simultaneous bilateral stimulation of the receptive fields (RF) on neural discharge. The cellular responses to unilateral ipsilateral and contralateral, as well as to bilateral stimulation were compared. 22% of bilateral cells showed interaction, usually facilitation. Bilaterally evoked responses were found to be as great as 250% of the strongest unilateral response. Only bilateral responses stronger or weaker than the dominant unilateral response by at least 50% were considered as interactive. The great majority of interactive cells had their RF on the forelimb and were responsive to deep stimulation. The corpus callosum appears to be responsible for part of the observed interaction since in callosotomized cats only 5% of bilateral cells were interactive. A non-callosal ipsilateral pathway must be postulated because both bilaterality and bilateral interaction persist to some degree after callosotomy. A putative role for bilateral interaction in sensory-motor integration is discussed.

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