Proton magnetic resonance spectroscopy of basal ganglia in chronic schizophrenia

Proton spectra in the regions of the right and left basal ganglia were studied in 14 medicated patients with chronic schizophrenia using proton magnetic resonance spectroscopy (1H MRS). Ratios of N-acetyl-aspartate (NAA) to choline-containing compounds (Cho) were significantly reduced in the bilateral basal ganglia regions compared to normal subjects. The relative level of Cho was increased in the left basal ganglia region in comparison to normal subjects. This finding suggests the presence of disturbances in phospholipid metabolism in the basal ganglia. The level of NAA was decreased in the bilateral basal ganglia regions, which may indicate neuronal dysfunction. The 1H MRS study demonstrated dysfunctions in the basal ganglia regions in medicated patients with chronic schizophrenia.

[1]  D L Braff,et al.  Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia. , 1991, Archives of general psychiatry.

[2]  S. Stone-Elander,et al.  D2 dopamine receptors in neuroleptic-naive schizophrenic patients. A positron emission tomography study with [11C]raclopride. , 1990, Archives of general psychiatry.

[3]  N. Minshew,et al.  31P Nuclear Magnetic Resonance Studies of Phosphoglyceride Metabolism in Developing and Degenerating Brain: Preliminary Observations , 1987, Journal of neuropathology and experimental neurology.

[4]  J. Frahm,et al.  Localized proton NMR spectroscopy in different regions of the human brain in vivo. Relaxation times and concentrations of cerebral metabolites , 1989, Magnetic resonance in medicine.

[5]  P Schmalbrock,et al.  Proton Magnetic Resonance Spectroscopy (1H MRS) of the Hippocampal Formation in Schizophrenia: A Pilot Study , 1994, British Journal of Psychiatry.

[6]  A. Brancati,et al.  Effects evoked by pentamethylenetetrazol-induced seizures upon N-acetylaspartate and N-acetylaspartylglutamate levels in different regions of the rat neuraxis. , 1991, Life sciences.

[7]  G. Matson,et al.  Neuron loss localizes human temporal lobe epilepsy by in vivo proton magnetic resonance spectroscopic imaging , 1993, Annals of neurology.

[8]  J. Overall,et al.  The Brief Psychiatric Rating Scale , 1962 .

[9]  G. Pearlson,et al.  Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. , 1986, Science.

[10]  B. Miller.  A review of chemical issues in 1H NMR spectroscopy: N‐acetyl‐l‐aspartate, creatine and choline , 1991, NMR in biomedicine.

[11]  R. Kauppinen,et al.  Brain metabolites as 1H NMR markers of neuronal and glial disorders , 1989, NMR in biomedicine.

[12]  T. Asakura,et al.  Study of chronic schizophrenics using 31P magnetic resonance chemical shift imaging , 1992, Acta psychiatrica Scandinavica.

[13]  J. Kleinman,et al.  Neuroimaging and neuropathology. , 1988, Schizophrenia bulletin.

[14]  T. Nakada,et al.  In vivo 1H and 31P NMR spectroscopy of the developing rat brain , 1992, Magnetic resonance in medicine.

[15]  Jimmy D Bell,et al.  1H NMR study of cerebral development in the rat , 1989, NMR in biomedicine.

[16]  Roland Kreis,et al.  Development of the human brain: In vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy , 1993, Magnetic resonance in medicine.

[17]  M. A. Samphilipo,et al.  Quantitative proton spectroscopy of canine brain: in Vivo and in Vitro correlations , 1994, Magnetic resonance in medicine.

[18]  B. Mazoyer,et al.  The Estimated Density of D2 Striatal Receptors in Schizophrenia , 1991, British Journal of Psychiatry.

[19]  M. Keshavan,et al.  Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy. , 1991, Archives of general psychiatry.