Mining the sociome for Health Informatics: Analysis of therapeutic lifestyle adherence of diabetic patients in Twitter

Abstract In recent years, the number of active users in social media has grown exponentially. Despite the thematic diversity of the messages, social media have become an important vehicle to disseminate health information as well as to gather insights about patients’ experiences and emotional intelligence. Therefore, the present work proposes a new methodology of analysis to identify and interpret the behaviour, perceptions and appreciations of patients and close relatives towards a health condition through their social interactions. At the core of this methodology are techniques of natural language processing and machine learning as well as the reconstruction of knowledge graphs, and further graph mining. The case study is the diabetes community, and more specifically, the patients communicating about type 1 diabetes (T1D) and type 2 diabetes (T2D). The results produced in this study show the effectiveness of the proposed method to discover useful and non-trivial knowledge about patient perceptions of disease. Such knowledge may be used in the context of Health Informatics to promote healthy lifestyles in more efficient ways as well as to improve communication with the patients.

[1]  Degui Zhi,et al.  Tweeting about measles during stages of an outbreak: A semantic network approach to the framing of an emerging infectious disease , 2018, American Journal of Infection Control.

[2]  Tsuyoshi Murata,et al.  {m , 1934, ACML.

[3]  Kyung Sup Kwak,et al.  DMTO: a realistic ontology for standard diabetes mellitus treatment , 2018, Journal of Biomedical Semantics.

[4]  Jonathan D Buckley,et al.  Comparison of low- and high-carbohydrate diets for type 2 diabetes management: a randomized trial. , 2015, The American journal of clinical nutrition.

[5]  Michelle Tew,et al.  Expenditures and Prices of Antihyperglycemic Medications in the United States: 2002-2013. , 2016, JAMA.

[6]  Elia Gabarron,et al.  Diabetes on Twitter: A Sentiment Analysis , 2018, Journal of diabetes science and technology.

[7]  M. Newman,et al.  Finding community structure in very large networks. , 2004, Physical review. E, Statistical, nonlinear, and soft matter physics.

[8]  Michael I. Jordan,et al.  Latent Dirichlet Allocation , 2001, J. Mach. Learn. Res..

[9]  J. Carroll,et al.  A New Dimension of Health Care: Systematic Review of the Uses, Benefits, and Limitations of Social Media for Health Communication , 2013, Journal of medical Internet research.

[10]  Huaiyu Zhu On Information and Sufficiency , 1997 .

[11]  Till Bärnighausen,et al.  Global Economic Burden of Diabetes in Adults: Projections From 2015 to 2030 , 2018, Diabetes Care.

[12]  Youngji Kim,et al.  Co-occurrence Network Analysis of Keywords in Geriatric Frailty , 2018 .

[13]  Francisco M. Couto,et al.  MER: a shell script and annotation server for minimal named entity recognition and linking , 2018, Journal of Cheminformatics.

[14]  Robert M. Anderson,et al.  Prevention or delay of type 2 diabetes. , 2004, Diabetes care.

[15]  P. Zimmet,et al.  The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives , 2012, Nature Reviews Endocrinology.

[16]  Gang Fu,et al.  Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data , 2014, Nucleic Acids Res..

[17]  Jeffrey Heer,et al.  Termite: visualization techniques for assessing textual topic models , 2012, AVI.

[18]  Li Yujian,et al.  A Normalized Levenshtein Distance Metric , 2007, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[19]  Mihai Surdeanu,et al.  The Stanford CoreNLP Natural Language Processing Toolkit , 2014, ACL.

[20]  Ramesh Kandimalla,et al.  Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal. , 2017, Biochimica et biophysica acta. Molecular basis of disease.

[21]  Kevin A Padrez,et al.  Twitter as a Tool for Health Research: A Systematic Review , 2017, American journal of public health.

[22]  Janet W. Levy,et al.  Social media for scientists , 2018, Nature Cell Biology.

[23]  F. Fdez-Riverola,et al.  Using Twitter to Understand the Human Bowel Disease Community: Exploratory Analysis of Key Topics , 2019, Journal of medical Internet research.

[24]  Maria Bardosova,et al.  Using network science and text analytics to produce surveys in a scientific topic , 2015, J. Informetrics.

[25]  Awad Magbri,et al.  Two Options the sweetest among them is bitter: Fournier-gangrene associated with sodium-glucose co-transporter 2-inhibitors , 2019, Global Journal of Urology and Nephrology.

[26]  Carol J Boushey,et al.  Table for two: diabetes distress and diet-related interactions of married patients with diabetes and their spouses. , 2012, Families, systems & health : the journal of collaborative family healthcare.

[27]  Sruthi Adimadhyam,et al.  Increased risk of mycotic infections associated with sodium–glucose co‐transporter 2 inhibitors: a prescription sequence symmetry analysis , 2018, British journal of clinical pharmacology.

[28]  Megan A Moreno,et al.  Adolescent Perspectives on the Use of Social Media to Support Type 1 Diabetes Management: Focus Group Study , 2019, Journal of medical Internet research.

[29]  Mauricio Barahona,et al.  The ‘who’ and ‘what’ of #diabetes on Twitter , 2015, Digital health.

[30]  Kenneth E. Shirley,et al.  LDAvis: A method for visualizing and interpreting topics , 2014 .

[31]  P. Leung,et al.  The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus , 2016, Nutrients.

[32]  Reza Zafarani,et al.  Social Media Mining: An Introduction , 2014 .

[33]  M E J Newman,et al.  Finding and evaluating community structure in networks. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[34]  Melinda D. Maryniuk,et al.  Diabetes Self-management Education and Support in Type 2 Diabetes , 2015, The Diabetes educator.

[35]  Elia Gabarron,et al.  Tweets are not always supportive of patients with mental disorders , 2017 .

[36]  Rodrigo J. S. Dalmolin,et al.  Preferential Duplication of Intermodular Hub Genes: An Evolutionary Signature in Eukaryotes Genome Networks , 2013, PloS one.

[37]  C. Howarth,et al.  Associations of Type 1 diabetes mellitus, maternal vascular disease and complications of pregnancy , 2007, Diabetic medicine : a journal of the British Diabetic Association.

[38]  Míriam Antón-Rodríguez,et al.  A content analysis of chronic diseases social groups on Facebook and Twitter. , 2012, Telemedicine journal and e-health : the official journal of the American Telemedicine Association.

[39]  George Shaw,et al.  Computational content analysis of negative tweets for obesity, diet, diabetes, and exercise , 2017, ASIST.

[40]  Wei Bao,et al.  Prevalence of diagnosed type 1 and type 2 diabetes among US adults in 2016 and 2017: population based study , 2018, British Medical Journal.

[41]  Allan Kuchinsky,et al.  GLay: community structure analysis of biological networks , 2010, Bioinform..

[42]  J. Sowers,et al.  Type 2 diabetes mellitus and hypertension: an update. , 2014, Endocrinology and metabolism clinics of North America.

[43]  Hadi Kharrazi,et al.  Characterizing Diabetes, Diet, Exercise, and Obesity Comments on Twitter , 2017, Int. J. Inf. Manag..

[44]  Elizabeth M. Borycki,et al.  Empowering patients through social media: The benefits and challenges , 2014, Health Informatics J..

[45]  Ernest C Davenport,et al.  Phi/Phimax: Review and Synthesis , 1991 .

[46]  Julio Raffo,et al.  Worldwide Gender-Name Dictionary , 2016 .

[47]  J. Novak,et al.  Evaluative Coping, Emotional Distress, and Adherence in Couples With Type 2 Diabetes , 2017, Families, systems & health : the journal of collaborative family healthcare.

[48]  Diego R. Amancio,et al.  Text Authorship Identified Using the Dynamics of Word Co-Occurrence Networks , 2016, PloS one.

[49]  Luciano da Fontoura Costa,et al.  Concentric network symmetry grasps authors' styles in word adjacency networks , 2015, ArXiv.

[50]  Rahmi Oklu,et al.  Social Medicine: Twitter in Healthcare , 2018, Journal of clinical medicine.

[51]  R. Whittemore,et al.  The Experience of Partners of Adults with Type 1 Diabetes: an Integrative Review , 2018, Current Diabetes Reports.

[52]  Luc Van Gool,et al.  DEX: Deep EXpectation of Apparent Age from a Single Image , 2015, 2015 IEEE International Conference on Computer Vision Workshop (ICCVW).

[53]  Emma Berry,et al.  Managing Type 2 diabetes as a couple: The influence of partners' beliefs on diabetes distress over time. , 2018, Diabetes research and clinical practice.

[54]  Carmen Castaneda-Sceppa,et al.  Physical activity/exercise and type 2 diabetes. , 2004, Diabetes care.

[55]  Eric Gilbert,et al.  VADER: A Parsimonious Rule-Based Model for Sentiment Analysis of Social Media Text , 2014, ICWSM.

[56]  Robert M. Anderson,et al.  The prevention or delay of type 2 diabetes. , 2002, Diabetes care.

[57]  Aidong Zhang,et al.  Identification of functional hubs and modules by converting interactome networks into hierarchical ordering of proteins , 2010, BMC Bioinformatics.

[58]  J. Shaw,et al.  IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. , 2018, Diabetes research and clinical practice.

[59]  Solomon Habtemariam,et al.  The Chemistry and Pharmacology of Citrus Limonoids , 2016, Molecules.

[60]  Kenneth Stephenson,et al.  A circle packing algorithm , 2003, Comput. Geom..

[61]  Ruslan Salakhutdinov,et al.  Evaluation methods for topic models , 2009, ICML '09.

[62]  S. Mohapatra,et al.  : DISEASE ONTOLOGY , 2014 .

[63]  David S. Wishart,et al.  DrugBank 5.0: a major update to the DrugBank database for 2018 , 2017, Nucleic Acids Res..

[64]  William H. Herman,et al.  The Cost of Diabetes Care—An Elephant in the Room , 2018, Diabetes Care.

[65]  David M Maahs,et al.  Epidemiology of type 1 diabetes. , 2010, Endocrinology and metabolism clinics of North America.

[66]  Julio César Hernández Castro,et al.  Detecting discussion communities on vaccination in twitter , 2017, Future Gener. Comput. Syst..

[67]  Martin G. Everett,et al.  Network text analysis: A two-way classification approach , 2020, Int. J. Inf. Manag..

[68]  Duncan J. Watts,et al.  Collective dynamics of ‘small-world’ networks , 1998, Nature.

[69]  J. Rosenstock,et al.  Dapagliflozin versus saxagliptin as add-on therapy in patients with type 2 diabetes inadequately controlled with metformin , 2018, Archives of endocrinology and metabolism.

[70]  K. Driscoll,et al.  Anxiety in Children and Adolescents With Type 1 Diabetes , 2015, Current Diabetes Reports.

[71]  G. J. Rodgers,et al.  Network properties of written human language. , 2006, Physical review. E, Statistical, nonlinear, and soft matter physics.

[72]  Mark Johnson,et al.  More Efficient Topic Modelling Through a Noun Only Approach , 2015, ALTA.

[73]  Johannes Naumann,et al.  Prevention and Therapy of Type 2 Diabetes—What Is the Potential of Daily Water Intake and Its Mineral Nutrients? , 2017, Nutrients.

[74]  Alaa Tharwat,et al.  Classification assessment methods , 2020, Applied Computing and Informatics.

[75]  Damion M. Dooley,et al.  FoodOn: a harmonized food ontology to increase global food traceability, quality control and data integration , 2018, npj Science of Food.