Verbal learning and memory in children with fetal alcohol syndrome.

Children with fetal alcohol syndrome (FAS) were administered the California Verbal Learning Test-Children's Version, a word list learning task that assesses immediate and delayed recall and recognition memory. When compared with matched control children, the children with FAS had difficulty learning and recalling the words after a delay period and tended to make an increased number of intrusion and perseverative errors. In addition, they had difficulty discriminating target words from distracter words and made more false-positive errors on recognition testing. Some of these deficits persisted even when mental age was controlled. The results suggest that children with FAS have profound verbal learning and memory deficits, and that some of these deficits cannot be accounted for even when mental age is considered. Furthermore, the results are consistent with deficits in encoding verbal information and impairment in response inhibition capabilities.

[1]  C. Gianoulakis,et al.  Rats exposed prenatally to alcohol exhibit impairment in spatial navigation test , 1990, Behavioural Brain Research.

[2]  E. Riley,et al.  Behavioral Teratology of Alcohol , 1986 .

[3]  H. Steinhausen,et al.  Long-term psychopathological and cognitive outcome of children with fetal alcohol syndrome. , 1993, Journal of the American Academy of Child and Adolescent Psychiatry.

[4]  E. Riley,et al.  The effects of prenatal alcohol exposure on odor associative learning in rats. , 1988, Neurotoxicology and teratology.

[5]  G. Chermak,et al.  Performance of American Indian children with fetal alcohol syndrome on the test of language development. , 1991, Journal of communication disorders.

[6]  David W. Smith,et al.  Intelligence, behavior, and dysmorphogenesis in the fetal alcohol syndrome: a report on 20 patients. , 1978, The Journal of pediatrics.

[7]  J. Cummings,et al.  Frontal-subcortical circuits and human behavior. , 1993, Journal of psychosomatic research.

[8]  J. Jacobson,et al.  Prenatal alcohol exposure and infant information processing ability. , 1993, Child development.

[9]  B. Watkinson,et al.  36− and 48‐Month Neurobehavioral Follow‐up of Children Prenatally Exposed to Marijuana, Cigarettes, and Alcohol , 1990, Journal of developmental and behavioral pediatrics : JDBP.

[10]  A. Streissguth,et al.  Prenatal alcohol exposure: comparability of effects in humans and animal models. , 1990, Neurotoxicology and teratology.

[11]  H. A. Leeper,et al.  Fetal alcohol syndrome: a description of oral motor, articulatory, short-term memory, grammatical, and semantic abilities. , 1990, Journal of communication disorders.

[12]  D. Delis,et al.  Fetal alcohol syndrome: a case report of neuropsychological, MRI and EEG assessment of two children. , 1992, Alcoholism, clinical and experimental research.

[13]  T. Jernigan,et al.  A decrease in the size of the basal ganglia following prenatal alcohol exposure: a preliminary report. , 1994, Neurotoxicology and Teratology.

[14]  P. Fried,et al.  60- and 72-month follow-up of children prenatally exposed to marijuana, cigarettes, and alcohol: cognitive and language assessment. , 1992, Journal of developmental and behavioral pediatrics : JDBP.

[15]  F L Bookstein,et al.  Neurobehavioral effects of prenatal alcohol: Part III. PLS analyses of neuropsychologic tests. , 1989, Neurotoxicology and teratology.

[16]  E P Riley,et al.  A decrease in the size of the basal ganglia in children with fetal alcohol syndrome. , 1996, Alcoholism, clinical and experimental research.

[17]  P. Sampson,et al.  Moderate prenatal alcohol exposure: effects on child IQ and learning problems at age 7 1/2 years. , 1990, Alcoholism, clinical and experimental research.

[18]  R. Sokol,et al.  Guidelines for use of terminology describing the impact of prenatal alcohol on the offspring. , 1989, Alcoholism, clinical and experimental research.

[19]  H. Steinhausen,et al.  Development and Psychopathology of Children with the Fetal Alcohol Syndrome , 1982, Journal of developmental and behavioral pediatrics : JDBP.

[20]  R. Berman,et al.  Radial arm maze deficits in rats exposed to alcohol during midgestation , 1994, Psychobiology.

[21]  D. Delis,et al.  Profiles of demented and amnesic patients on the California verbal learning test : implications for the assessment of memory disorders , 1991 .

[22]  I. Autti-Rämö,et al.  Mental development of 2-year-old children exposed to alcohol in utero. , 1992, The Journal of pediatrics.

[23]  Julianne L. Conry,et al.  Neuropsychological deficits in fetal alcohol syndrome and fetal alcohol effects. , 1990, Alcoholism, clinical and experimental research.

[24]  F. Bookstein,et al.  Maternal drinking during pregnancy: attention and short-term memory in 14-year-old offspring--a longitudinal prospective study. , 1994, Alcoholism, clinical and experimental research.

[25]  David W. Smith,et al.  Recognition of the fetal alcohol syndrome in early infancy. , 1973, Lancet.