Calorie restricted diet and urinary pentosidine in patients with rheumatoid arthritis.

Low-energy diets and fasting have suppressive effects on rheumatoid arthritis. It was reported recently that urine levels of pentosidine (i.e., an advanced glycation end product formed by glycosylation) is associated with the activity of rheumatoid arthritis. We conducted a regimen of caloric restriction combined with fasting in patients with rheumatoid arthritis, and then evaluated urinary pentosidine levels. Ten patients with rheumatoid arthritis underwent a 54-day caloric restriction program. Urinary pentosidine levels were measured and the Lansbury Index were determined by examining the clinical features, blood biochemistry and the inflammation activity of rheumatoid arthritis on days 0, 25 and 54. On day 0, the mean urinary pentosidine level of patients with rheumatoid arthritis was significantly higher than that of the control subjects. On day 54, the mean body weight had reduced due to caloric restriction. The mean values of the erythrocyte sedimentation rate and the Lansbury Index of patients both significantly decreased during the study. In addition, although the urinary pentosidine levels showed no significant difference between day 0 and 25, it was significantly decreased at the end of the study (day 54). The study showed that under a low energy diet a reduction of disease activity in rheumatoid arthritis was accompanied with a reduction of the urinary pentosidine.

[1]  K. Kouda,et al.  Low-energy diet in atopic dermatitis patients: clinical findings and DNA damage. , 2000, Journal of physiological anthropology and applied human science.

[2]  K. Kushida,et al.  Relationship between pentosidine levels in serum and urine and activity in rheumatoid arthritis. , 1997, British journal of rheumatology.

[3]  K. Kouda,et al.  Effects of Dietary Restriction on Spontaneous Dermatitis in NC/Nga Mice , 2001, Experimental biology and medicine.

[4]  M. Herkenham,et al.  Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. , 1990, Neuroendocrinology.

[5]  K. Reiser,et al.  Influence of age and long-term dietary restriction on enzymatically mediated crosslinks and nonenzymatic glycation of collagen in mice. , 1994, Journal of gerontology.

[6]  H. D. Johnson,et al.  Physiologic and immune responses associated with 48-hour fast of pigs. , 1992, Laboratory animal science.

[7]  D. Beri,et al.  Effect of dietary restrictions on disease activity in rheumatoid arthritis. , 1988, Annals of the rheumatic diseases.

[8]  J. Lansbury.  Numerical Method of Evaluating the Status of Rheumatoid Arthritis * , 1958, Annals of the rheumatic diseases.

[9]  P. Mantellini,et al.  [Methods for evaluating rheumatoid arthritis]. , 1967, Archivio di ortopedia.

[10]  T. Tabei,et al.  Vegetarian diet ameliorates symptoms of atopic dermatitis through reduction of the number of peripheral eosinophils and of PGE2 synthesis by monocytes. , 2001, Journal of physiological anthropology and applied human science.

[11]  L. Sköldstam,et al.  Influence of fasting on intestinal permeability and disease activity in patients with rheumatoid arthritis. , 1982, Scandinavian journal of rheumatology.

[12]  V. Monnier,et al.  Maillard Reaction-Mediated Molecular Damage to Extracellular Matrix and Other Tissue Proteins in Diabetes, Aging, and Uremia , 1992, Diabetes.

[13]  K. Kushida,et al.  Comparison of the concentrations of pentosidine in the synovial fluid, serum and urine of patients with rheumatoid arthritis and osteoarthritis. , 1999, Rheumatology.

[14]  J. Palmblad,et al.  Neutrophil functions and clinical performance after total fasting in patients with rheumatoid arthritis. , 1983, Annals of the rheumatic diseases.

[15]  H. Klandorf,et al.  Age-related changes in meat tenderness and tissue pentosidine: effect of diet restriction and aminoguanidine in broiler breeder hens. , 1999, Poultry science.

[16]  T. Ohishi,et al.  The Maillard protein cross-link pentosidine in urine from diabetic patients , 1993, Diabetologia.

[17]  K. Kouda,et al.  Reduced oxidative DNA damage by vegetable juice intake: a controlled trial. , 2000, Journal of physiological anthropology and applied human science.

[18]  L. Sköldstam,et al.  Effect of fasting and lactovegetarian diet on rheumatoid arthritis. , 1979, Scandinavian journal of rheumatology.

[19]  K. Kouda,et al.  The relationship of oxidative DNA damage marker 8-hydroxydeoxyguanosine and glycoxidative damage marker pentosidine. , 2001, Clinical biochemistry.

[20]  N. Ramsey,et al.  PLACEBO-CONTROLLED, BLIND STUDY OF DIETARY MANIPULATION THERAPY IN RHEUMATOID ARTHRITIS , 1986, The Lancet.

[21]  S. Bloom,et al.  The effect of a 72-h fast on plasma levels of pituitary, adrenal, thyroid, pancreatic and gastrointestinal hormones in healthy men and women. , 1989, The Journal of endocrinology.

[22]  R. Stroud,et al.  Food-induced (allergic) arthritis. Inflammatory arthritis exacerbated by milk. , 1986, Arthritis and rheumatism.

[23]  W. A. Johnson,et al.  Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[24]  F. Epstein,et al.  Rheumatoid arthritis. Pathophysiology and implications for therapy. , 1990, The New England journal of medicine.

[25]  O. Førre,et al.  Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis , 1991, The Lancet.

[26]  G. Firestein.  Mechanisms of tissue destruction and cellular activation in rheumatoid arthritis. , 1992, Current opinion in rheumatology.

[27]  W. Cefalu,et al.  Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[28]  G. Rechkemmer,et al.  Consumption of vegetables reduces genetic damage in humans: first results of a human intervention trial with carotenoid-rich foods. , 1997, Carcinogenesis.

[29]  H. Thompson,et al.  Effect of increased vegetable and fruit consumption on markers of oxidative cellular damage. , 1999, Carcinogenesis.

[30]  Takeuchi,et al.  8‐Hydroxydeoxyguanosine in urine as an index of oxidative damage to DNA in the evaluation of atopic dermatitis , 1998, The British journal of dermatology.

[31]  Richard Weindruch,et al.  The Retardation of Aging and Disease by Dietary Restriction , 1988 .

[32]  M. Liang,et al.  The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. , 1988, Arthritis and rheumatism.

[33]  V. Monnier,et al.  Structure elucidation of a senescence cross-link from human extracellular matrix. Implication of pentoses in the aging process. , 1989, The Journal of biological chemistry.

[34]  K. Kouda,et al.  Suppressive Effects on Allergic Contact Dermatitis by Short-Term Fasting , 2001, Toxicologic pathology.

[35]  T. Osawa,et al.  Spice constituents scavenging free radicals and inhibiting pentosidine formation in a model system. , 1997, Bioscience, biotechnology, and biochemistry.

[36]  T. Komori,et al.  The influence of physical restraint or fasting on plaque‐forming cell response in mice , 1996, Psychiatry and clinical neurosciences.

[37]  R. Good,et al.  Influence of dietary restriction on immunologic function and renal disease in (NZB x NZW) F1 mice. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[38]  S. Ikehara,et al.  Influence of dietary energy restriction on the numbers and proportions of Ly-1+ B lymphocytes in autoimmunity-prone mice. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[39]  W. Peters,et al.  Effect of Brussels sprouts on oxidative DNA-damage in man. , 1997, Cancer letters.

[40]  T. Inoue,et al.  Fluorophores from aging human articular cartilage. , 1991, Journal of biochemistry.

[41]  B. Yu,et al.  Aging and oxidative stress: modulation by dietary restriction. , 1996, Free radical biology & medicine.

[42]  K. Kushida,et al.  Direct quantification of pentosidine in urine and serum by HPLC with column switching. , 1996, Clinical chemistry.

[43]  T. Miyata,et al.  Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions. , 1999, Journal of the American Society of Nephrology : JASN.

[44]  V. Monnier,et al.  Age-related association of tail tendon break time with tissue pentosidine in DBA/2 vs C57BL/6 mice: the effect of dietary restriction. , 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.

[45]  S. Ali,et al.  Formation of calcium phosphate crystals in normal and osteoarthritic cartilage. , 1983, Annals of the rheumatic diseases.

[46]  K. Kushida,et al.  Pentosidine in synovial fluid in osteoarthritis and rheumatoid arthritis: relationship with disease activity in rheumatoid arthritis. , 1998, The Journal of rheumatology.

[47]  J. Palmblad,et al.  Effects of fasting on disease activity, neutrophil function, fatty acid composition, and leukotriene biosynthesis in patients with rheumatoid arthritis. , 1988, Arthritis and rheumatism.