The effect of ultrasonic oscillations of different frequencies on radionuclide accumulation in the eye tissues

: The paper describes results of experimental investigations in 25 rabbits for the purpose to study permeability of eye tissues under the action of ultrasound of different frequencies (127, 295, 470, 660, 880, 1000, 2750 kHz). The following radioactive nuclides were used: 99mTc--pertechnetate, 125I in a form of KI and 45CaCl2. In investigations with 99mTc--pertechnetate and 45CaCl2, their accumulation in the aqueous humor, vitreous body, cornea, iris, sclera, crystalline lens, choroid and retina was studied. It was found that permeability of eye tissues depends, to a great extent, on ultrasound frequency. The highest amount of radionuclides penetrate into the eye media and eye tissues under the action of ultrasound with 470, 660, 880 kHz frequencies. With increase or decrease of ultrasound frequency the permeability decreases. This fact should be considered when applying phonophoresis.