Liver Cancers in Mayak Workers

Abstract Gilbert, E. S., Koshurnikova, N. A., Sokolnikov, M., Khokhryakov, V. F., Miller, S., Preston, D. L., Romanov, S. A., Shilnikova, N. S., Suslova, K. G. and Vostrotin, V. V. Liver Cancers in Mayak Workers. Liver cancer mortality risks were evaluated in 11,000 workers who started working at the “Mayak” Production Association in 1948–1958 and who were exposed to both internally deposited plutonium and external γ radiation. Comparisons with Russian liver cancer incidence rates indicate excess risk, especially among those with detectable plutonium body burdens and among female workers in the plutonium plant. Comparisons within the Mayak worker cohort which evaluate the role of plutonium body burden with adjustment for cumulative external dose indicate excess risk among workers with burdens estimated to exceed 7.4 kBq (relative risk = 17; 95% CI = 8.0–36) and among workers in the plutonium plant who did not have routine plutonium monitoring data based on urine measurements (relative risk = 2.8; 95% CI = 1.3–6.2). In addition, analyses treating the estimated plutonium body burden as a continuous variable indicate increasing risk with increasing burden (P < 0.001). Relative risks tended to be higher for females than for males, probably because of the lower baseline risk and the higher levels of plutonium measured in females. Because of limitations in current plutonium dosimetry, no attempt was made to quantify liver cancer risks from plutonium in terms of organ dose, and risk from external dose could not be reliably evaluated.

[1]  P. Eifel.  Chemoradiation for Carcinoma of the Cervix: Advances and Opportunities , 2000, Radiation research.

[2]  P. Amy,et al.  Effect of gamma radiation on native endolithic microorganisms from a radioactive waste deposit site. , 1999, Radiation research.

[3]  R J Waxweiler,et al.  Mortality among plutonium and other radiation workers at a plutonium weapons facility. , 1987, American journal of epidemiology.

[4]  D. Preston,et al.  Cancer incidence in atomic bomb survivors. Part IV: Comparison of cancer incidence and mortality. , 1994, Radiation research.

[5]  C. W. Mays,et al.  Plutonium- or americium-induced liver tumors and lesions in beagles. , 1991, Health physics.

[6]  J. F. Park,et al.  Statistical modeling of carcinogenic risks in dogs that inhaled 238PuO2. , 1998, Radiation research.

[7]  G. Beebe,et al.  Effects of radiation on incidence of primary liver cancer among atomic bomb survivors. , 1999, Radiation research.

[8]  J. Lawrence,et al.  A 42-y medical follow-up of Manhattan Project plutonium workers. , 1991, Health physics.

[9]  Z. B. Tokarskaya,et al.  The influence of radiation and nonradiation factors on the lung cancer incidence among the workers of the nuclear enterprise Mayak. , 1995, Health physics.

[10]  N A Koshurnikova,et al.  Bone Cancers in Mayak Workers , 2000, Radiation research.

[11]  G. R. Petersen,et al.  Mortality of workers at the Hanford site: 1945-1981. , 1989, Health physics.

[12]  H. Storm,et al.  Cancer incidence among Danish Thorotrast-exposed patients. , 1992, Journal of the National Cancer Institute.

[13]  P. Okatenko,et al.  Lung cancer mortality among nuclear workers of the Mayak facilities in the former Soviet Union , 2003, Radiation research.

[14]  P. Okatenko,et al.  Lung Cancer Mortality among Male Nuclear Workers of the Mayak Facilities in the Former Soviet Union , 2000 .

[15]  I. B. Keirim-Markus,et al.  Lung cancer risk due to exposure to incorporated plutonium. , 1998, Radiation research.

[16]  L. Wiggs,et al.  Mortality through 1990 among white male workers at the Los Alamos National Laboratory: considering exposures to plutonium and external ionizing radiation. , 1994, Health physics.

[17]  D. Preston,et al.  Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958-1987. , 1994, Radiation research.

[18]  G. van Kaick,et al.  The german thorotrast study: recent results and assessment of risks. , 1999, Radiation research.

[19]  D A Pierce,et al.  Studies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer: 1950-1990. , 1996, Radiation research.

[20]  P. Smith,et al.  CALENDAR , 1984, British Journal of Cancer.