Primary cilia regulate mTORC1 activity and cell size through Lkb1

[1]  Oliver Senn,et al.  Sirolimus and kidney growth in autosomal dominant polycystic kidney disease. , 2010, The New England journal of medicine.

[2]  Donald E Ingber,et al.  Mechanical control of tissue and organ development , 2010, Development.

[3]  D. Sabatini,et al.  mTOR signaling at a glance , 2009, Journal of Cell Science.

[4]  B. Yoder,et al.  The Primary Cilium as a Complex Signaling Center , 2009, Current Biology.

[5]  V. Torres,et al.  Autosomal dominant polycystic kidney disease: the last 3 years. , 2009, Kidney international.

[6]  H. Clevers,et al.  LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. , 2009, Physiological reviews.

[7]  M. Zou,et al.  Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for Its Nucleocytoplasmic Transport and Endothelial Cell Angiogenesis , 2009, Molecular and Cellular Biology.

[8]  J. Blenis,et al.  Molecular mechanisms of mTOR-mediated translational control , 2009, Nature Reviews Molecular Cell Biology.

[9]  P. Polak,et al.  mTOR and the control of whole body metabolism. , 2009, Current opinion in cell biology.

[10]  P. Pandolfi,et al.  Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1 , 2009, Molecular and Cellular Biology.

[11]  M. Schwartz,et al.  Regulation of LKB1/STRAD Localization and Function by E-Cadherin , 2009, Current Biology.

[12]  J. Auwerx,et al.  Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. , 2008, Cell metabolism.

[13]  R. Nitschke,et al.  TRPP2 and TRPV4 form a polymodal sensory channel complex , 2008, The Journal of cell biology.

[14]  P. Igarashi,et al.  Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. , 2008, Human molecular genetics.

[15]  R. Nitschke,et al.  Flow modulates centriole movements in tubular epithelial cells , 2008, Pflügers Archiv - European Journal of Physiology.

[16]  H. Omran,et al.  When cilia go bad: cilia defects and ciliopathies , 2007, Nature Reviews Molecular Cell Biology.

[17]  R. Nitschke,et al.  Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1) , 2007, Pflügers Archiv: European Journal of Physiology.

[18]  Rebecca M. Jones,et al.  Hyperactivation of Mammalian Target of Rapamycin (mTOR) Signaling by a Gain-of-Function Mutant of the Rheb GTPase* , 2006, Journal of Biological Chemistry.

[19]  Kei Sakamoto,et al.  LKB1-dependent signaling pathways. , 2006, Annual review of biochemistry.

[20]  A. Novick,et al.  The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[21]  P. Wahl,et al.  Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD). , 2006, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[22]  M. Hall,et al.  TOR Signaling in Growth and Metabolism , 2006, Cell.

[23]  Didier Y. R. Stainier,et al.  Vertebrate Smoothened functions at the primary cilium , 2005, Nature.

[24]  Qihong Zhang,et al.  Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function , 2005, PLoS genetics.

[25]  Robert T. Abraham,et al.  Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 Is Mediated by p70S6 Kinase* , 2005, Journal of Biological Chemistry.

[26]  Y. Tao,et al.  Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease. , 2004, Journal of the American Society of Nephrology : JASN.

[27]  K. Kaibuchi,et al.  Role of the PAR-3–KIF3 complex in the establishment of neuronal polarity , 2004, Nature Cell Biology.

[28]  Sheldon Weinbaum,et al.  Effect of flow and stretch on the [Ca2+]i response of principal and intercalated cells in cortical collecting duct. , 2003, American journal of physiology. Renal physiology.

[29]  M. Wiznerowicz,et al.  Conditional Suppression of Cellular Genes: Lentivirus Vector-Mediated Drug-Inducible RNA Interference , 2003, Journal of Virology.

[30]  Jing Zhou,et al.  Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells , 2003, Nature Genetics.

[31]  Takeharu Nagai,et al.  Crystal Structure of Venus, a Yellow Fluorescent Protein with Improved Maturation and Reduced Environmental Sensitivity* , 2002, The Journal of Biological Chemistry.

[32]  J. Avruch,et al.  Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action , 2002, Cell.

[33]  D. Sabatini,et al.  mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery , 2002, Cell.

[34]  J. Blenis,et al.  Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. , 2002, Molecular cell.

[35]  K. R. Spring,et al.  Bending the MDCK Cell Primary Cilium Increases Intracellular Calcium , 2001, The Journal of Membrane Biology.

[36]  G. Pazour,et al.  Chlamydomonas IFT88 and Its Mouse Homologue, Polycystic Kidney Disease Gene Tg737, Are Required for Assembly of Cilia and Flagella , 2000, The Journal of cell biology.

[37]  W. Richards,et al.  The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. , 2000, Development.

[38]  A. Evan,et al.  Cyst formation and growth in autosomal dominant polycystic kidney disease. , 1987, Kidney international.

[39]  J. Stockman,et al.  Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease , 2012 .

[40]  J. Rosenbaum,et al.  Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling. , 2008, Current topics in developmental biology.

[41]  Amy E. Shyer,et al.  Kif3a constrains β-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms , 2008, Nature Cell Biology.

[42]  J. Rosenbaum,et al.  Chapter Two Intraflagellar Transport (IFT) , 2008 .

[43]  B. Yoder,et al.  Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737orpk mutant mice , 2005, Laboratory Investigation.

[44]  Robert C. Thompson,et al.  Printed in U.S.A. Copyright © 2000 by The Endocrine Society Localization of Glucokinase-Like Immunoreactivity in the Rat Lower Brain Stem: For Possible Location of , 2022 .

[45]  Robert C. Thompson,et al.  Localization of Glucokinase-Like Immunoreactivity in the Rat Lower Brain Stem: For Possible Location of Brain Glucose-Sensing Mechanisms1. , 2000, Endocrinology.