论文信息 - Tailoring of Bone Scaffold Properties Using Silicate/Phosphate Glass Mixtures

Tailoring of Bone Scaffold Properties Using Silicate/Phosphate Glass Mixtures

Different ratios of a resorbable phosphate glass (ICEL) and a bioactive silicate glass (CEL2) were co-sintered to obtain 3D porous scaffolds by gel-cast foaming method. The scaffold morphology, crystalline phases and compressive strength were studied. All the scaffolds showed a 3D structure with highly interconnected pores. The ICEL/CEL2 co-sintering resulted in a lower shrinkage leading to higher scaffold porosity (more than 70 vol%) compared to pure ICEL and CEL2 (about 65 vol%). Tuning ICEL/CEL2 ratio allowed the modulation of the scaffold resorption rate, with weight loss ranging from 20% to 75% after soaking for 3 months in simulated body fluid. Scaffolds containing higher amount of CEL2 silicate glass, resulted in a very high bioactivity. In vitro biological test showed no toxic effect of the scaffolds on human osteoblast-like cells.

[1] Francesco Baino,et al. Foam-like scaffolds for bone tissue engineering based on a novel couple of silicate-phosphate specular glasses: synthesis and properties , 2009, Journal of materials science. Materials in medicine.

[2] Julian R Jones,et al. Melt-derived bioactive glass scaffolds produced by a gel-cast foaming technique. , 2011, Acta biomaterialia.

[3] J. Knowles. Phosphate based glasses for biomedical applications , 2003 .

[4] Larry L. Hench,et al. Genetic design of bioactive glass , 2009 .

[5] G. Muzio,et al. Development of glass-ceramic scaffolds for bone tissue engineering: characterisation, proliferation of human osteoblasts and nodule formation. , 2007, Acta biomaterialia.