Calcyclin Mediates Serum Response Element (SRE) Activation by an Osteoblastic Extracellular Cation‐Sensing Mechanism

The molecular mechanism of sensing extracellular cations in osteoblasts is controversial. Using an expression‐cloning strategy, the calcium‐binding protein calcyclin was found to mediate the response of MC3T3‐E1 osteoblasts to extracellular cations, but not the calcimimetic NPS‐568, indicating the presence of another cation‐sensing mechanism. Further understanding of calcyclin function in osteoblasts may identify novel targets for regulating bone formation.

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