PHARMACOLOGICAL STUDIES OF YASHTIMADHU (GLYCYRRHIZA GLABRA L.) IN VARIOUS ANIMAL MODELS - A REVIEW

Plants are one of the most important sources of medicines. Yashtimadhu [Glycyrrhiza glabra] is one such plant which symbolizes all that is wondrous in nature because, the whole plant has been used as traditional medicine for household remedy against various human ailments from antiquity. The objective of this paper is to review the literature regarding various pharmacological actions. The canvas of the pharmacological activities of Yashtimadhu is very vast. When these activities were complied Yashtimadhu stands out strongly as a drug of choice in various disorders. This paper reviews the available data on use of Yashtimadhu [Glycyrrhiza glabra] in various disorders as evidenced in these topics.

[1]  T. Angelone,et al.  Glycyrrhizin and glycyrrhetinic acid directly modulate rat cardiac performance. , 2012, The Journal of nutritional biochemistry.

[2]  Xiaodong Sun,et al.  Glycyrrhizin could reduce ocular hypertension induced by triamcinolone acetonide in rabbits , 2011, Molecular vision.

[3]  P. Hasanein.  Glabridin as a major active isoflavan from Glycyrrhiza glabra (licorice) reverses learning and memory deficits in diabetic rats. , 2011, Acta physiologica Hungarica.

[4]  P. Capek,et al.  Structural features and in vivo antitussive activity of the water extracted polymer from Glycyrrhiza glabra. , 2011, International journal of biological macromolecules.

[5]  Y. Liu,et al.  Protective effects of glycyrrhizic acid by rectal treatment on a TNBS‐induced rat colitis model , 2011, The Journal of pharmacy and pharmacology.

[6]  M. Razi,et al.  Protective effects of melatonin and Glycyrrhiza glabra extract on ochratoxin A—induced damages on testes in mature rats , 2011, Human & experimental toxicology.

[7]  Anjali Sharma,et al.  Prevention of acetaminophen induced hepatorenal damage in mice with rhizomes of Glycyrrhiza glabra A histophysiological study , 2011, Ancient science of life.

[8]  S. Lim,et al.  Anti-Inflammatory Effects of Licorice and Roasted Licorice Extracts on TPA-Induced Acute Inflammation and Collagen-Induced Arthritis in Mice , 2010, Journal of biomedicine & biotechnology.

[9]  D. Herndon,et al.  Pivotal Advance: Glycyrrhizin restores the impaired production of β‐defensins in tissues surrounding the burn area and improves the resistance of burn mice to Pseudomonas aeruginosa wound infection , 2010, Journal of leukocyte biology.

[10]  P. He,et al.  Hepatoprotective and anti-hepatocarcinogenic effects of glycyrrhizin and matrine. , 2009, Chemico-biological interactions.

[11]  Marjan Nassiri-Asl,et al.  Antiandrogenic activities of Glycyrrhiza glabra in male rats. , 2009, International journal of andrology.

[12]  Yang Liu,et al.  Isoliquiritigenin, a flavonoid from licorice, plays a dual role in regulating gastrointestinal motility in vitro and in vivo , 2009, Phytotherapy research : PTR.

[13]  E. Mazzon,et al.  GLYCYRRHIZIN REDUCES SECONDARY INFLAMMATORY PROCESS AFTER SPINAL CORD COMPRESSION INJURY IN MICE , 2009, Shock.

[14]  H. Kamisoyama,et al.  Investigation of the Anti-Obesity Action of Licorice Flavonoid Oil in Diet-Induced Obese Rats , 2008, Bioscience, biotechnology, and biochemistry.

[15]  Hyun-Joung Lim,et al.  Anti-proliferative effect of licochalcone A on vascular smooth muscle cells. , 2008, Biological & pharmaceutical bulletin.

[16]  P. Muralidharan,et al.  Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract on hypoxic rats , 2008 .

[17]  E. D. Gol’dberg,et al.  Licorice preparations improve efficiency of chemotherapy and surgical treatment of transplanted tumors , 2008, Bulletin of Experimental Biology and Medicine.

[18]  M. Mohan,et al.  Glycyrrhiza glabra as an adjuvant in treatment of Parkinsonism and depression , 2008 .

[19]  E. Mazzon,et al.  Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice. , 2008, Pharmacological research.

[20]  Y. Li,et al.  Isoliquiritigenin, a flavonoid from licorice, relaxes guinea-pig tracheal smooth muscle in vitro and in vivo: role of cGMP/PKG pathway. , 2008, European journal of pharmacology.

[21]  R. Fetterer,et al.  Immunostimulating Complexes Incorporating Eimeria tenella Antigens and Plant Saponins as Effective Delivery System for Coccidia Vaccine Immunization , 2008, The Journal of parasitology.

[22]  M. Ao,et al.  Effect of Glabridin from Glycyrrhiza glabra on Learning and Memory in Mice , 2008, Planta medica.

[23]  Shufeng Zhou,et al.  In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice). , 2008, Life sciences.

[24]  Yun-Lian Lin,et al.  Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats , 2008, Phytotherapy research : PTR.

[25]  M. Eisenhut,et al.  Antiviral effects of Glycyrrhiza species , 2007, Phytotherapy research : PTR.

[26]  Yeong Shik Kim,et al.  Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice. , 2007, Biological & pharmaceutical bulletin.

[27]  S. Minasian,et al.  [Changes of morphological indicators of blood from vibration and liquorice effect]. , 2007, Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova.

[28]  A. Kinghorn,et al.  Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). , 2007, Journal of agricultural and food chemistry.

[29]  Yeong Shik Kim,et al.  In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components. , 2007, Planta medica.

[30]  V. Lankin,et al.  Antioxidant activity of parapharmaceutics containing natural inhibitors of free radical processes , 2000, Bulletin of Experimental Biology and Medicine.

[31]  D. Bhatnagar,et al.  Free radical scavenging activity, metal chelation and antioxidant power of some of the Indian spices , 2007, BioFactors.

[32]  N. Visavadiya,et al.  Hypocholesterolaemic and antioxidant effects of Glycyrrhiza glabra (Linn) in rats. , 2006, Molecular nutrition & food research.

[33]  U. Mabalirajan,et al.  Glycyrrhizin alleviates experimental allergic asthma in mice. , 2006, International immunopharmacology.

[34]  S. Kulkarni,et al.  Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, ascorbic acid, and metrifonate in mice. , 2006, Journal of medicinal food.

[35]  Amandeep Sharma,et al.  Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests , 2006, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[36]  A. Dorhoi,et al.  Modulatory effects of several herbal extracts on avian peripheral blood cell immune responses , 2006, Phytotherapy research : PTR.

[37]  Jing Yang,et al.  Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats. , 2006, Pharmacological research.

[38]  S. Minasyan,et al.  Effect of Licorice Root on Peripheral Blood Indexes upon Vibration Exposure , 2005, Bulletin of Experimental Biology and Medicine.

[39]  R. Balaraman,et al.  Anti-ulcer and anti-oxidant activity of pepticare, a herbomineral formulation. , 2005, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[40]  R. Balaraman,et al.  Antioxidant activity of DHC‐1, an herbal formulation, in experimentally‐induced cardiac and renal damage , 2005, Phytotherapy research : PTR.

[41]  S. Kulkarni,et al.  Memory-strengthening activity of Glycyrrhiza glabra in exteroceptive and interoceptive behavioral models. , 2004, Journal of medicinal food.

[42]  H. Kishida,et al.  Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A(y) mice. , 2004, Biological & pharmaceutical bulletin.

[43]  M. Rajesh,et al.  Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachloride-induced peroxidative damage , 2004 .

[44]  V. Salvi,et al.  Radioprotection of DNA by glycyrrhizic acid through scavenging free radicals. , 2004, Journal of radiation research.

[45]  K. Oganesyan.  Antioxidant Effect of Licorice Root on Blood Catalase Activity in Vibration Stress , 2002, Bulletin of Experimental Biology and Medicine.

[46]  J. A. Guimarães,et al.  Antithrombotic effect of Glycyrrhizin, a plant-derived thrombin inhibitor. , 2003, Thrombosis research.

[47]  C. Nair,et al.  Protection of DNA and microsomal membranes in vitro by Glycyrrhiza glabra L. against gamma irradiation , 2002, Phytotherapy research : PTR.

[48]  U. Alekperov.  Plant antimutagens and their mixtures in inhibition of genotoxic effects of xenobiotics and aging processes. , 2002, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[49]  S. Kasture,et al.  Anticonvulsant activity of roots and rhizomes of Glycyrrhiza glabra , 2002 .

[50]  L. Mahran,et al.  Antiulcerogenic Effect of Some Gastrointestinally Acting Plant Extracts and their Combination , 2001, Arzneimittelforschung.

[51]  S. Krylova,et al.  [Medicinal plant preparations used as adjuvant therapeutics in experimental oncology]. , 2000, Eksperimental'naia i klinicheskaia farmakologiia.

[52]  M. Sogorb,et al.  Dichlorophenyl phosphoramidates as substrates for avian and mammalian liver phosphotriesterases: activity levels, calcium dependence and stereospecificity. , 1999, Chemico-biological interactions.