Application of 3-Dimensional Printing Technology to Construct an Eye Model for Fundus Viewing Study

Objective To construct a life-sized eye model using the three-dimensional (3D) printing technology for fundus viewing study of the viewing system. Methods We devised our schematic model eye based on Navarro's eye and redesigned some parameters because of the change of the corneal material and the implantation of intraocular lenses (IOLs). Optical performance of our schematic model eye was compared with Navarro's schematic eye and other two reported physical model eyes using the ZEMAX optical design software. With computer aided design (CAD) software, we designed the 3D digital model of the main structure of the physical model eye, which was used for three-dimensional (3D) printing. Together with the main printed structure, polymethyl methacrylate(PMMA) aspherical cornea, variable iris, and IOLs were assembled to a physical eye model. Angle scale bars were glued from posterior to periphery of the retina. Then we fabricated other three physical models with different states of ammetropia. Optical parameters of these physical eye models were measured to verify the 3D printing accuracy. Results In on-axis calculations, our schematic model eye possessed similar size of spot diagram compared with Navarro's and Bakaraju's model eye, much smaller than Arianpour's model eye. Moreover, the spherical aberration of our schematic eye was much less than other three model eyes. While in off- axis simulation, it possessed a bit higher coma and similar astigmatism, field curvature and distortion. The MTF curves showed that all the model eyes diminished in resolution with increasing field of view, and the diminished tendency of resolution of our physical eye model was similar to the Navarro's eye. The measured parameters of our eye models with different status of ametropia were in line with the theoretical value. Conclusions The schematic eye model we designed can well simulate the optical performance of the human eye, and the fabricated physical one can be used as a tool in fundus range viewing research.

[1]  A. Kooijman,et al.  Light distribution on the retina of a wide-angle theoretical eye. , 1983, Journal of the Optical Society of America.

[2]  R. K. Murthy,et al.  Evaluation of ultra wide angle "ora-ora" high refractive index self-stabilizing contact lens for vitreous surgery. , 2010, Retina.

[3]  R. Navarro,et al.  Off-axis aberrations of a wide-angle schematic eye model. , 1999, Journal of the Optical Society of America. A, Optics, image science, and vision.

[4]  T. Mihashi,et al.  Quality of image of grating target placed in model of human eye with corneal aberrations as observed through multifocal intraocular lenses. , 2011, American journal of ophthalmology.

[5]  M. Ohji,et al.  Combining a Contact Lens and Wide-Angle Viewing System for a Wider Fundus View , 2011, Retina.

[6]  Arthur Ho,et al.  Physical human model eye and methods of its use to analyse optical performance of soft contact lenses. , 2010, Optics express.

[7]  Stefano Bozza,et al.  Optomechanical eye model with imaging capabilities for objective evaluation of intraocular lenses , 2006, Journal of cataract and refractive surgery.

[8]  Donald R. Sanders,et al.  Development of the SRK/T intraocular lens implant power calculation formula , 1990, Journal of cataract and refractive surgery.

[9]  K. Ohnuma,et al.  Quality of image of grating target placed in model eye and observed through toric intraocular lenses. , 2013, American journal of ophthalmology.

[10]  Marrie van der Mooren,et al.  A new intraocular lens design to reduce spherical aberration of pseudophakic eyes. , 2002, Journal of refractive surgery.

[11]  Kakarla V Chalam,et al.  Optics of wide-angle panoramic viewing system-assisted vitreous surgery. , 2004, Survey of ophthalmology.

[12]  James P. C. Southall,et al.  Optical system of the eye. , 1924 .

[13]  Ashkan Arianpour,et al.  An optomechanical model eye for ophthalmological refractive studies. , 2013, Journal of refractive surgery.

[14]  A. Tünnermann,et al.  Optical side-effects of fs-laser treatment in refractive surgery investigated by means of a model eye , 2013, Biomedical optics express.

[15]  Tatjana Dostalova,et al.  Possibility of reconstruction of dental plaster cast from 3D digital study models , 2013, Biomedical engineering online.

[16]  N. Kaneko,et al.  Development of three-dimensional hollow elastic model for cerebral aneurysm clipping simulation enabling rapid and low cost prototyping. , 2015, World neurosurgery.

[17]  R. Navarro,et al.  Accommodation-dependent model of the human eye with aspherics. , 1985, Journal of the Optical Society of America. A, Optics and image science.

[18]  Margam Chandrasekaran,et al.  Rapid prototyping in tissue engineering: challenges and potential. , 2004, Trends in biotechnology.

[19]  R. D. Watkins,et al.  THE OPTICAL SYSTEM OF THE EYE , 1970 .

[20]  A. Langenbucher,et al.  Assessing the optical performance of multifocal (diffractive) intraocular lenses , 2008, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[21]  K. Nishida,et al.  Commercially available rigid gas-permeable contact lens for protecting the cornea from drying during vitrectomy with a wide viewing system , 2012, Clinical ophthalmology.

[22]  Patricia Piers,et al.  Model eyes for evaluation of intraocular lenses. , 2007, Applied optics.

[23]  T. Q. Huang,et al.  3D printing of biomimetic microstructures for cancer cell migration , 2014, Biomedical microdevices.

[24]  J. Schwiegerling,et al.  Optical performance measurement and night driving simulation of ReSTOR, ReZoom, and Tecnis multifocal intraocular lenses in a model eye. , 2008, Journal of refractive surgery.