论文信息 - HIV-1 REVERSE TRANSCRIPTASE

HIV-1 REVERSE TRANSCRIPTASE

Human immunodeficiency virus (HIV) is the etiologic agent causing the Acquired Immunodeficiency Syndrome (AIDS), the world's most deadly infectious disease. According to the World Health Organization the total number of people living with the human immunodeficiency virus (HIV) rose in 2004 to reach its highest level ever: an estimated 39.4 million. In 2004 alone, approximately 4.9 million people acquired HIV, while the global AIDS epidemic killed 3.1 million people in the past year (6). HIV is a member of the retrovirus family. An essential element in the life cycle of this family of viruses is the requirement for integrating a copy of its genetic material (genome) into the human host cell genome before virus replication can occur. HIV Reverse Transcriptase enzyme (RT) is responsible for producing the DNA copy of the viral RNA genome that will be integrated into the human DNA.

[1] A. D. Clark,et al. Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution. , 1998, Journal of molecular biology.

[2] T. Steitz,et al. Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[3] T. Steitz,et al. Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[4] S. Hughes. Molecular matchmaking: NNRTIs can enhance the dimerization of HIV type 1 reverse transcriptase , 2001, Proceedings of the National Academy of Sciences of the United States of America.