The α‐synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: A study of 230 European cases

We report the results of a screen of 230 European familial index cases of Parkinson's disease for the recently described Ala53Thr mutation in the α‐synuclein gene in an autosomal dominant Parkinson's disease kindred. No mutations were found from this broad white population, and we therefore conclude that although of great interest, this mutation is a very rare cause of familial Parkinson's disease.

[1]  C. Marsden,et al.  Sequencing of the α-Synuclein Gene in a Large Series of Cases of Familial Parkinson's Disease Fails to Reveal any Further Mutations , 1998 .

[2]  C. Marsden,et al.  Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease , 1997, The Lancet.

[3]  M. L. Schmidt,et al.  α-Synuclein in Lewy bodies , 1997, Nature.

[4]  Y. Agid,et al.  Genetic complexity and Parkinson's disease. , 1997, Science.

[5]  Robert L. Nussbaum,et al.  Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease , 1997 .

[6]  D J Burn,et al.  Dopaminergic function in familial Parkinson's disease: A clinical and 18F‐dopa positron emission tomography study , 1997, Annals of neurology.

[7]  M. Polymeropoulos,et al.  Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23 , 1996, Science.

[8]  L. Golbe,et al.  Clinical genetic analysis of Parkinson's disease in the contursi kindred , 1996, Annals of neurology.

[9]  G. Meco,et al.  Familial Parkinson’s Disease: A Clinical Genetic Analysis , 1995, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[10]  J. Parisi,et al.  Western Nebraska Family (Family D) with Autosomal Dominant Parkinsonism , 1995, Neurology.

[11]  J. Gusella,et al.  Genetic linkage studies in autosomal dominant parkinsonism: Evaluation of seven candidate genes , 1994, Annals of neurology.

[12]  A. E. Harding,et al.  Parkinson's disease in twins studied with 18F‐dopa and positron emission tomography , 1992, Neurology.

[13]  B. Summers,et al.  Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease , 1992, The Lancet.

[14]  R. Scheller,et al.  The rat brain synucleins; family of proteins transiently associated with neuronal membrane. , 1991, Brain research. Molecular brain research.

[15]  C. Marsden,et al.  A clinical and genetic study of familial Parkinson's disease , 1991, Movement disorders : official journal of the Movement Disorder Society.

[16]  C. Marsden Parkinson's disease in twins. , 1987, Journal of neurology, neurosurgery, and psychiatry.

[17]  S. Roy,et al.  Parkinson's disease in a Scottish city. , 1986, British medical journal.

[18]  C. Ward,et al.  Parkinson's disease in 65 pairs of twins and in a set of quadruplets , 1983, Neurology.

[19]  O. Lowenstein Advances in oto-rhino-laryngology, vol. 18 , 1974 .