Toxic Nephrosis caused by Kanamycin in a Calf

Pathologic investigation was performed on the kidney of a calf treated with massive doses of kanamycin. Macroscopically, the renal cortex was a pale yellowish-brown color. Histopathologically, vacuolar degeneration and coagulative necrosis of the renal tubular epithelial cells, particularly in the proximal tubules and dilation of the renal tubules containing cellular debris were observed. Dilation of the renal collecting tubules and hyaline droplet degeneration of the collecting tublar epithelia were also seen, though glomerular changes were not observed. This case was diagnosed as a toxic tubulo-nephrosis caused by kanamycin.-