Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase.
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G. Castellano | A. Tomassetti | S. Canevari | G. Nicolini | A. Anichini | M. Catani | I. Bersani | M. Sensi | G. Avanzi | G. Tragni | G. De Santis | F. Alciato
[1] Nikhil Wagle,et al. Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[2] J. Choi,et al. Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta‐analysis , 2011, The British journal of dermatology.
[3] K. Hoek,et al. Cancer stem cells versus phenotype‐switching in melanoma , 2010, Pigment cell & melanoma research.
[4] Marc Vidal,et al. COT/MAP3K8 drives resistance to RAF inhibition through MAP kinase pathway reactivation , 2010, Nature.
[5] R. Weimer,et al. An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies , 2010, Oncogene.
[6] H. Earp,et al. Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors , 2010, Expert opinion on therapeutic targets.
[7] Y. Hitoshi,et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. , 2010, Cancer research.
[8] Tom Royce,et al. A comprehensive catalogue of somatic mutations from a human cancer genome , 2010, Nature.
[9] Bjørn Tore Gjertsen,et al. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival , 2009, Proceedings of the National Academy of Sciences.
[10] C. Print,et al. A Gene Expression Signature of Invasive Potential in Metastatic Melanoma Cells , 2009, PloS one.
[11] Buu P. Tu,et al. A genomic screen identifies TYRO3 as a MITF regulator in melanoma , 2009, Proceedings of the National Academy of Sciences.
[12] Jimmy Lin,et al. Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4 , 2009, Nature Genetics.
[13] D. Fisher,et al. Transcriptional regulation in melanoma. , 2009, Hematology/oncology clinics of North America.
[14] Chenwei Wang,et al. Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma , 2009, Nature Genetics.
[15] A. Tomassetti,et al. E-cadherin directly contributes to PI3K/AKT activation by engaging the PI3K-p85 regulatory subunit to adherens junctions of ovarian carcinoma cells , 2009, Oncogene.
[16] G. Nicolini,et al. Peptides with dual binding specificity for HLA-A2 and HLA-E are encoded by alternatively spliced isoforms of the antioxidant enzyme peroxiredoxin 5. , 2009, International immunology.
[17] D. Polsky,et al. Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor , 2009, Proceedings of the National Academy of Sciences.
[18] R. Dummer,et al. Novel MITF targets identified using a two‐step DNA microarray strategy , 2008, Pigment cell & melanoma research.
[19] K. Tai,et al. Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-κB and Brg-1 , 2008, Oncogene.
[20] Thomas D. Schmittgen,et al. Analyzing real-time PCR data by the comparative CT method , 2008, Nature Protocols.
[21] L. Castello,et al. Development and Validation of an ELISA Method for Detection of Growth Arrest Specific 6 (GAS6) Protein in Human Plasma , 2008, Journal of immunoassay & immunochemistry.
[22] R. Dummer,et al. In vivo switching of human melanoma cells between proliferative and invasive states. , 2008, Cancer research.
[23] G. Cavet,et al. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL , 2007, Nature Medicine.
[24] Jane Goodall,et al. Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. , 2006, Genes & development.
[25] D. Pinkel,et al. Somatic activation of KIT in distinct subtypes of melanoma. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[26] D. Schadendorf,et al. Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature. , 2006, Pigment cell research.
[27] Stephen T. C. Wong,et al. Multiple roles for the receptor tyrosine kinase axl in tumor formation. , 2005, Cancer research.
[28] G. Nicolini,et al. Immunogenicity without immunoselection: a mutant but functional antioxidant enzyme retained in a human metastatic melanoma and targeted by CD8(+) T cells with a memory phenotype. , 2005, Cancer research.
[29] M. Pierotti,et al. BRAF alterations are associated with complex mutational profiles in malignant melanoma , 2004, Oncogene.
[30] Markus Ringnér,et al. Microarray expression profiling in melanoma reveals a BRAF mutation signature , 2004, Oncogene.
[31] G. V. van Muijen,et al. Cancer/testis‐associated genes: Identification, expression profile, and putative function , 2003, Journal of cellular physiology.
[32] D. Albert,et al. Expression of the Receptor Tyrosine Kinase Axl Promotes Ocular Melanoma Cell Survival , 2004, Cancer Research.
[33] David Eisenberg,et al. Bioinformatic identification of potential autocrine signaling loops in cancers from gene expression profiles , 2001, Nature Genetics.
[34] N. Sampas,et al. Molecular classification of cutaneous malignant melanoma by gene expression profiling , 2000, Nature.
[35] A. Anichini,et al. Cytotoxic T cells directed to tumor antigens not expressed on normal melanocytes dominate HLA-A2.1-restricted immune repertoire to melanoma. , 1996, Journal of immunology.
[36] H. Yamane,et al. Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6 , 1995, Nature.
[37] M. Herlyn,et al. Protein kinases in normal and transformed melanocytes , 1994, Melanoma research.
[38] R. Espinosa,et al. axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase , 1991, Molecular and cellular biology.