Panaxadiol saponin ameliorates ferroptosis in iron-overload aplastic anemia mice and Meg-01 cells by activating Nrf2/HO-1 and PI3K/AKT/mTOR signaling pathway.

[1]  K. Tao,et al.  Maresin1 Protect Against Ferroptosis-Induced Liver Injury Through ROS Inhibition and Nrf2/HO-1/GPX4 Activation , 2022, Frontiers in Pharmacology.

[2]  Chen Fu,et al.  Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia. , 2022, Journal of ethnopharmacology.

[3]  Wei Wei,et al.  Ginsenoside Rg1 can restore hematopoietic function by inhibiting Bax translocation-mediated mitochondrial apoptosis in aplastic anemia , 2021, Scientific Reports.

[4]  H. Leitch,et al.  Iron Overload-Induced Oxidative Stress in Myelodysplastic Syndromes and its Cellular Sequelae. , 2021, Critical reviews in oncology/hematology.

[5]  Junjie Chen,et al.  mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation , 2021, Nature Communications.

[6]  M. Conrad,et al.  The Metabolic Underpinnings of Ferroptosis. , 2020, Cell metabolism.

[7]  X. Cui,et al.  Angelica sinensis polysaccharide prevents mitochondrial apoptosis by regulating the Treg/Th17 ratio in aplastic anemia , 2020, BMC Complementary Medicine and Therapies.

[8]  J. Ajani,et al.  The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression , 2020, Cell Research.

[9]  B. Chong,et al.  Panaxdiol Saponins Component Promotes Hematopoiesis and Modulates T Lymphocyte Dysregulation in Aplastic Anemia Model Mice , 2019, Chinese Journal of Integrative Medicine.

[10]  Hong Liu,et al.  Pathogenesis of aplastic anemia , 2019, Hematology.

[11]  Dijiong Wu,et al.  The Progress of Traditional Chinese Medicine in the Treatment of Aplastic Anemia , 2018, Journal of translational internal medicine.

[12]  R. Latagliata,et al.  Iron toxicity - Its effect on the bone marrow. , 2018, Blood reviews.

[13]  Wenbin Liu,et al.  Comparison of the effects of deferasirox, deferoxamine, and combination of deferasirox and deferoxamine on an aplastic anemia mouse model complicated with iron overload , 2018, Drug design, development and therapy.

[14]  Wenbin Liu,et al.  A composite mouse model of aplastic anemia complicated with iron overload , 2017, Experimental and therapeutic medicine.

[15]  A. Dasgupta,et al.  Intracellular iron overload leading to DNA damage of lymphocytes and immune dysfunction in thalassemia major patients , 2017, European journal of haematology.

[16]  P. Northcott,et al.  Genomic Analysis of Childhood Brain Tumors: Methods for Genome-Wide Discovery and Precision Medicine Become Mainstream. , 2017, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  Yiying Zhao,et al.  RPA3 is a potential marker of prognosis and radioresistance for nasopharyngeal carcinoma , 2017, Journal of cellular and molecular medicine.

[18]  A. Levis,et al.  Erythroid response during iron chelation therapy in a cohort of patients affected by hematologic malignancies and aplastic anemia with transfusion requirement and iron overload: a FISM Italian multicenter retrospective study , 2017, Leukemia & lymphoma.

[19]  P. Ponikowski,et al.  Both iron excess and iron depletion impair viability of rat H9C2 cardiomyocytes and L6G8C5 myocytes. , 2016, Kardiologia polska.

[20]  Donghai Huang,et al.  Genome-wide analyses of long noncoding RNA expression profiles correlated with radioresistance in nasopharyngeal carcinoma via next-generation deep sequencing , 2016, BMC Cancer.

[21]  Yue-min Kuang,et al.  Clinical study of Pai-Neng-Da capsule (派能达胶囊) in the treatment of chronic aplastic anemia , 2016, Chinese Journal of Integrative Medicine.

[22]  Hong Chang,et al.  地拉罗司对伴有铁过载的再生障碍性贫血患者的祛铁疗效及安全性——一项单臂、多中心、前瞻性临床研究 , 2016, Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi.

[23]  E. Katsanis,et al.  The complex pathophysiology of acquired aplastic anaemia , 2015, Clinical and experimental immunology.

[24]  V. Beneš,et al.  Lymphocyte Gene Expression Signatures from Patients and Mouse Models of Hereditary Hemochromatosis Reveal a Function of HFE as a Negative Regulator of CD8+ T-Lymphocyte Activation and Differentiation In Vivo , 2015, PloS one.

[25]  C. Krawczyk,et al.  Iron Prevents the Development of Experimental Cerebral Malaria by Attenuating CXCR3-Mediated T Cell Chemotaxis , 2015, PloS one.

[26]  C. Schürch,et al.  Cytotoxic CD8+ T cells stimulate hematopoietic progenitors by promoting cytokine release from bone marrow mesenchymal stromal cells. , 2014, Cell stem cell.

[27]  N. Young,et al.  Current concepts in the pathophysiology and treatment of aplastic anemia. , 2013, Hematology. American Society of Hematology. Education Program.

[28]  Di Wu,et al.  Bone marrow angiogenesis in patients presenting with differential Chinese medicine syndrome: Correlation with the clinico-pathological features of aplastic anemia , 2013, Chinese Journal of Integrative Medicine.

[29]  J. Werner,et al.  Reactive Oxygen Species in the Immune System , 2013, International reviews of immunology.

[30]  E. Weinberg,et al.  Iron availability and infection. , 2009, Biochimica et biophysica acta.

[31]  M. Tomonaga,et al.  Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes , 2008, International journal of hematology.

[32]  J. Karnon,et al.  Cost-utility analysis of deferasirox compared to standard therapy with desferrioxamine for patients requiring iron chelation therapy in the United Kingdom* , 2008, Current medical research and opinion.

[33]  Hung-Ming Wang,et al.  Differentially expressed genes in radioresistant nasopharyngeal cancer cells: gp96 and GDF15 , 2007, Molecular Cancer Therapeutics.

[34]  Shi-hui Li,et al.  [Clinical efficacy and T-lymphocyte subset, serum interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2(IL-2) levels on treatment of chronic aplastic anemia patients by shenfu injection combined with stanozol and cyclosporin A]. , 2005, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[35]  Zaccheaus Awortu. Jeremiah.  [Idiopathic thrombocytopenic purpura]. , 1964, Chirurgia e patologia sperimentale.

[36]  A. Azarkeivan,et al.  Comparison of iron chelation effects of deferoxamine, deferasirox, and combination of deferoxamine and deferiprone on liver and cardiac T2* MRI in thalassemia maior , 2017, Caspian journal of internal medicine.

[37]  Xin Sun,et al.  Effects of panaxadiol saponins component as a new Chinese patent medicine on proliferation, differentiation and corresponding gene expression profile of megakaryocytes , 2015, Chinese Journal of Integrative Medicine.