Supplementing culture medium with the weak acid, 5,5-dimethyl-2,4-oxazolidinedione (DMO) limits the development of aneuploid mouse embryos through a Trp53-dependent mechanism.

[1]  K. Sermon,et al.  On the origins and fate of chromosomal abnormalities in human preimplantation embryos: an unsolved riddle. , 2022, Molecular human reproduction.

[2]  A. Brivanlou,et al.  Author Correction: Depletion of aneuploid cells in human embryos and gastruloids , 2021, Nature cell biology.

[3]  N. Treff,et al.  The "mosaic" embryo: misconceptions and misinterpretations in preimplantation genetic testing for aneuploidy. , 2021, Fertility and sterility.

[4]  OUP accepted manuscript , 2021, Human Reproduction.

[5]  D. Barber,et al.  Intracellular pH Regulates Cancer and Stem Cell Behaviors: A Protein Dynamics Perspective , 2020, Frontiers in Oncology.

[6]  M. Zernicka-Goetz,et al.  Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism , 2020, Nature Communications.

[7]  N. Gatimel,et al.  Need for choosing the ideal pH value for IVF culture media , 2020, Journal of Assisted Reproduction and Genetics.

[8]  S. Kahraman,et al.  The birth of a baby with mosaicism resulting from a known mosaic embryo transfer: a case report , 2020, Human reproduction.

[9]  F. Tang,et al.  Reconstituting the transcriptome and DNA methylome landscapes of human implantation , 2019, Nature.

[10]  G. Smith,et al.  Embryonic POU5F1 is Required for Expanded Bovine Blastocyst Formation , 2018, Scientific Reports.

[11]  R. McCoy.  Mosaicism in Preimplantation Human Embryos: When Chromosomal Abnormalities Are the Norm. , 2017, Trends in genetics : TIG.

[12]  C. Cinnioğlu,et al.  Current experience concerning mosaic embryos diagnosed during preimplantation genetic screening. , 2017, Fertility and sterility.

[13]  C. Schneider,et al.  OCT4 controls mitotic stability and inactivates the RB tumor suppressor pathway to enhance ovarian cancer aggressiveness , 2017, Oncogene.

[14]  G. Kroemer,et al.  Caspase 2 in mitotic catastrophe: The terminator of aneuploid and tetraploid cells , 2017, Molecular & cellular oncology.

[15]  D. Green,et al.  Caspase-2-mediated cell death is required for deleting aneuploid cells , 2016, Oncogene.

[16]  Alvaro Plaza Reyes,et al.  Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos , 2016, Cell.

[17]  Parveen Kumar,et al.  Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential , 2016, Nature Communications.

[18]  M. Zernicka-Goetz,et al.  Maternal-zygotic knockout reveals a critical role of Cdx2 in the morula to blastocyst transition , 2015, Developmental biology.

[19]  D. Gardner.  Lactate production by the mammalian blastocyst: Manipulating the microenvironment for uterine implantation and invasion? , 2015, BioEssays : news and reviews in molecular, cellular and developmental biology.

[20]  J. Baltz,et al.  NHE1 Is the Sodium-Hydrogen Exchanger Active in Acute Intracellular pH Regulation in Preimplantation Mouse Embryos1 , 2013, Biology of reproduction.

[21]  Sjoerd Repping,et al.  Molecular origin of mitotic aneuploidies in preimplantation embryos. , 2012, Biochimica et biophysica acta.

[22]  R. Krisher,et al.  A role for the Warburg effect in preimplantation embryo development: Metabolic modification to support rapid cell proliferation , 2012, Molecular reproduction and development.

[23]  M. Kyba,et al.  p53 Regulates Cell Cycle and MicroRNAs to Promote Differentiation of Human Embryonic Stem Cells , 2012, PLoS biology.

[24]  M. Lane,et al.  Alterations in mouse embryo intracellular pH by DMO during culture impair implantation and fetal growth. , 2010, Reproductive biomedicine online.

[25]  M. Pantaleon,et al.  Characterization and Regulation of Monocarboxylate Cotransporters Slc16a7 and Slc16a3 in Preimplantation Mouse Embryos1 , 2008, Biology of reproduction.

[26]  C. O'neill,et al.  Culture of Zygotes Increases p53 Expression in B6 Mouse Embryos, which Reduces Embryo Viability1 , 2007 .

[27]  R. Behringer,et al.  Collecting zygotes and removing cumulus cells with hyaluronidase. , 2006, CSH protocols.

[28]  T. Esmaeilpour,et al.  Glucose affects monocarboxylate cotransporter (MCT) 1 expression during mouse preimplantation development. , 2006, Reproduction.

[29]  Jacques Cohen,et al.  Association of abnormal morphology and altered gene expression in human preimplantation embryos. , 2005, Fertility and sterility.

[30]  N. Steuerwald,et al.  Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation development. , 2005, Human reproduction.

[31]  K. P. Phillips,et al.  Intracellular pH regulation in human preimplantation embryos. , 2000, Human reproduction.

[32]  D. Williams,et al.  Intracellular pH of the mouse preimplantation embryo: amino acids act as buffers of intracellular pH. , 1998, Human reproduction.

[33]  R. Schultz,et al.  Apoptosis during mouse blastocyst formation: evidence for a role for survival factors including transforming growth factor alpha. , 1997, Biology of reproduction.

[34]  J. Baltz.  Intracellular pH regulation in the early embryo , 1993, BioEssays : news and reviews in molecular, cellular and developmental biology.

[35]  H. Leese,et al.  Glucose, pyruvate, and lactate concentrations in the blastocoel cavity of rat and mouse embryos , 1993, Molecular reproduction and development.