Acute Leukemia Presenting as Acute Hepatitis Without Liver Failure

ABSTRACT A diagnosis of acute lymphoblastic or myeloblastic leukemia was made in 6 children ages 4 to 14 years who presented with a clinicobiochemical picture of acute hepatitis without liver failure. Standard chemotherapy, including 1 week pretreatment with steroids in children with lymphoblastic leukemia, allowed complete remission of the leukemia and normalization of serum liver tests.

[1]  B. Collins,et al.  Liver transplantation in an adolescent with acute liver failure from acute lymphoblastic leukemia , 2014, Pediatric transplantation.

[2]  A. Elsharkawy,et al.  Clinical and laboratory features and natural history of seronegative hepatitis in a nontransplant centre , 2013, European journal of gastroenterology & hepatology.

[3]  R. Schreiber,et al.  Abnormal liver transaminases and conjugated hyperbilirubinemia at presentation of acute lymphoblastic leukemia , 2010, Pediatric blood & cancer.

[4]  M. Hudson,et al.  Childhood acute lymphoblastic leukemia presenting with severe hepatic dysfunction. , 2001, Medical and pediatric oncology.

[5]  D. Valla,et al.  Hepatic manifestations of hemophagocytic syndrome: a study of 30 cases , 2001, American Journal of Gastroenterology.

[6]  D. L. Gang,et al.  Hepatic Dysfunction as the Presenting Feature of Acute Lymphoblastic Leukemia , 2001, Journal of pediatric hematology/oncology.

[7]  M. Ciocca,et al.  Acute Lymphoblastic Leukemia Presenting as Acute Hepatic Failure in Childhood , 2000, Leukemia & lymphoma.

[8]  K. Sugita,et al.  Histopathologic features of the biopsied liver at onset of childhood B-precursor acute lymphoblastic leukemia presenting as severe jaundice. , 1997, Journal of pediatric gastroenterology and nutrition.

[9]  M. Fabre,et al.  Early pre-B acute lymphoblastic leukemia presenting as fulminant liver failure. , 1996, Journal of pediatric gastroenterology and nutrition.

[10]  E. Gilbert,et al.  Acute leukemia presenting as jaundice with acute liver failure. , 1973, Clinical pediatrics.