Interplay between miRNAs and human diseases

MicroRNAs (miRNAs) are endogenous, non‐coding RNAs, which have evoked a great deal of interest due to their importance in many aspects of homeostasis and diseases. MicroRNAs are stable and are essential components of gene regulatory networks. They play a crucial role in healthy individuals and their dysregulations have also been implicated in a wide range of diseases, including diabetes, cardiovascular disease, kidney disease, and cancer. This review summarized the current understanding of interactions between miRNAs and different diseases and their role in disease diagnosis and therapy.

[1]  Peter A. Jones,et al.  Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. , 2006, Cancer cell.

[2]  M. Michael.  Cloning microRNAs from mammalian tissues. , 2006, Methods in molecular biology.

[3]  Y. Yatabe,et al.  Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival , 2004, Cancer Research.

[4]  M. Gessler,et al.  Loss of Heterozygosity at 2q37 in Sporadic Wilms' Tumor: Putative Role for miR-562 , 2009, Clinical Cancer Research.

[5]  K. Livak,et al.  Real-time quantification of microRNAs by stem–loop RT–PCR , 2005, Nucleic acids research.

[6]  Peter A. Jones,et al.  Epigenetic Activation of Tumor Suppressor MicroRNAs in Human Cancer Cells , 2006, Cell cycle.

[7]  A. Bosserhoff,et al.  Strong reduction of AGO2 expression in melanoma and cellular consequences , 2013, British Journal of Cancer.

[8]  Xiaoxia Qi,et al.  Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA , 2007, Science.

[9]  V. Ambros,et al.  The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 , 1993, Cell.

[10]  K. Ishibashi,et al.  [Aquaporin water channels]. , 1996, Nihon rinsho. Japanese journal of clinical medicine.

[11]  G. Condorelli,et al.  Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia , 2011, Circulation.

[12]  Daniel B. Martin,et al.  Circulating microRNAs as stable blood-based markers for cancer detection , 2008, Proceedings of the National Academy of Sciences.

[13]  Yong Liu,et al.  MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor β1: a novel role of miR-382 , 2010, Nucleic acids research.

[14]  V. Kim,et al.  MicroRNA maturation: stepwise processing and subcellular localization , 2002, The EMBO journal.

[15]  L. Kobzik,et al.  MicroRNA-181b regulates NF-κB-mediated vascular inflammation. , 2012, The Journal of clinical investigation.

[16]  E. Børsheim,et al.  The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing , 2014, Genes.

[17]  Huan Sun,et al.  MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation , 2010, Molecular Biology Reports.

[18]  L. Lim,et al.  An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans , 2001, Science.

[19]  D. Guarnieri,et al.  MicroRNAs: A new class of gene regulators , 2008, Annals of medicine.

[20]  Stijn van Dongen,et al.  miRBase: microRNA sequences, targets and gene nomenclature , 2005, Nucleic Acids Res..

[21]  P. Fasanaro,et al.  MicroRNA Dysregulation in Diabetic Ischemic Heart Failure Patients , 2012, Diabetes.

[22]  Shu Liu,et al.  Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway. , 2010, Genes & development.

[23]  R. Plasterk,et al.  The diverse functions of microRNAs in animal development and disease. , 2006, Developmental cell.

[24]  C. Croce,et al.  MicroRNA gene expression deregulation in human breast cancer. , 2005, Cancer research.

[25]  C. Croce,et al.  An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[26]  C. Croce,et al.  The role of microRNA genes in papillary thyroid carcinoma. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[27]  C. Benz,et al.  Rapid alteration of microRNA levels by histone deacetylase inhibition. , 2006, Cancer research.

[28]  D. Fraser,et al.  MicroRNAs in Diabetic Nephropathy: From Biomarkers to Therapy , 2016, Current Diabetes Reports.

[29]  E. Furth,et al.  Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster , 2006, Nature Genetics.

[30]  John J Rossi,et al.  MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-β-induced collagen expression via inhibition of E-box repressors , 2007, Proceedings of the National Academy of Sciences.

[31]  P. Hougaard,et al.  Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression , 2012, Experimental diabetes research.

[32]  R. Schrier,et al.  Hypertension in autosomal-dominant polycystic kidney disease: early occurrence and unique aspects. , 2001, Journal of the American Society of Nephrology : JASN.

[33]  Da-Zhi Wang,et al.  MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress , 2013, Circulation research.

[34]  H. Lan.  Transforming growth factor‐β/Smad signalling in diabetic nephropathy , 2012, Clinical and experimental pharmacology & physiology.

[35]  J. Rossi,et al.  TGF-β activates Akt kinase via a microRNA-dependent amplifying circuit targeting PTEN , 2009, Nature Cell Biology.

[36]  C. Pizarro,et al.  MicroRNAs miR-21a and miR-93 are down regulated in peripheral blood mononuclear cells (PBMCs) from patients with type 1 diabetes. , 2013, Immunobiology.

[37]  K. Zhou,et al.  MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model. , 2013, Investigative ophthalmology & visual science.

[38]  Ting Chen,et al.  MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages. , 2009, Cardiovascular research.

[39]  Debora S. Marks,et al.  Antisense-Mediated Depletion Reveals Essential and Specific Functions of MicroRNAs in Drosophila Development , 2005, Cell.

[40]  M. Mayr,et al.  Analytical challenges and technical limitations in assessing circulating MiRNAs , 2012, Thrombosis and Haemostasis.

[41]  U. Lehmann,et al.  Epigenetic inactivation of microRNA gene hsa‐mir‐9‐1 in human breast cancer , 2008, The Journal of pathology.

[42]  E. Olson,et al.  MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment. , 2013, The Journal of clinical investigation.

[43]  T. Saruta,et al.  An overview of blood pressure regulation associated with the kidney. , 2004, Contributions to nephrology.

[44]  M. Prentki,et al.  Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes , 2013, Diabetologia.

[45]  Sinae Kim,et al.  MiRNA-155 targets myosin light chain kinase and modulates actin cytoskeleton organization in endothelial cells. , 2014, American journal of physiology. Heart and circulatory physiology.

[46]  M. N. Poy,et al.  microRNAs and the regulation of glucose and lipid metabolism , 2007, Diabetes, obesity & metabolism.

[47]  Joel S Parker,et al.  Extensive post-transcriptional regulation of microRNAs and its implications for cancer. , 2006, Genes & development.

[48]  E. Olson,et al.  Therapeutic Inhibition of miR-208a Improves Cardiac Function and Survival During Heart Failure , 2011, Circulation.

[49]  Matthias Merkenschlager,et al.  Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. , 2008, Journal of the American Society of Nephrology : JASN.

[50]  V. Velculescu,et al.  Implications of micro-RNA profiling for cancer diagnosis , 2006, Oncogene.

[51]  F. Dotta,et al.  Increased expression of microRNA miR‐326 in type 1 diabetic patients with ongoing islet autoimmunity , 2011, Diabetes/metabolism research and reviews.

[52]  P. Klotman,et al.  Recent progress in HIV-associated nephropathy. , 2002, Journal of the American Society of Nephrology : JASN.

[53]  M. Joglekar,et al.  MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3. , 2007, Developmental biology.

[54]  B. Harfe,et al.  The microRNA-processing enzyme dicer maintains juxtaglomerular cells. , 2010, Journal of the American Society of Nephrology : JASN.

[55]  C. Croce,et al.  Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[56]  H. Grosshans,et al.  MicroRNA turnover: when, how, and why. , 2012, Trends in biochemical sciences.

[57]  M. Esteller,et al.  Impaired DICER1 function promotes stemness and metastasis in colon cancer , 2013, Oncogene.

[58]  Yong Dai,et al.  Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients , 2009, Rheumatology International.

[59]  G. Maira,et al.  Extensive modulation of a set of microRNAs in primary glioblastoma. , 2005, Biochemical and biophysical research communications.

[60]  Zhiguo Wang.  miRNAs Targeting and Targeting miRNAs , 2009 .

[61]  U. Kutay,et al.  Nuclear Export of MicroRNA Precursors , 2004, Science.

[62]  T. Tuschl,et al.  Identification of Novel Genes Coding for Small Expressed RNAs , 2001, Science.

[63]  Tsung-Cheng Chang,et al.  Widespread microRNA repression by Myc contributes to tumorigenesis , 2008, Nature Genetics.

[64]  Mihaela Zavolan,et al.  miR-375 maintains normal pancreatic α- and β-cell mass , 2009, Proceedings of the National Academy of Sciences.

[65]  D. Bartel.  MicroRNAs Genomics, Biogenesis, Mechanism, and Function , 2004, Cell.

[66]  H. Nishimatsu,et al.  miR-200b Precursor Can Ameliorate Renal Tubulointerstitial Fibrosis , 2010, PloS one.

[67]  Chang-gong Liu,et al.  miRNA-548c: a specific signature in circulating PBMCs from dilated cardiomyopathy patients. , 2013, Journal of molecular and cellular cardiology.

[68]  You-yi Zhang,et al.  miR‐1/miR‐206 regulate Hsp60 expression contributing to glucose‐mediated apoptosis in cardiomyocytes , 2010, FEBS letters.

[69]  Shuiping Zhao,et al.  MicroRNA-143/-145 in Cardiovascular Diseases , 2015, BioMed research international.

[70]  Chaoqian Xu,et al.  The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes , 2007, Journal of Cell Science.

[71]  Jinqiao Qian,et al.  The role of microRNA in modulating myocardial ischemia-reperfusion injury. , 2011, Physiological genomics.

[72]  R. Duisters,et al.  MIRNA-133 AND MIRNA-30 REGULATE CONNECTIVE TISSUE GROWTH FACTOR: IMPLICATIONS FOR A ROLE OF MIRNAS IN MYOCARDIAL MATRIX REMODELING , 2013 .

[73]  N. Rajewsky,et al.  A pancreatic islet-specific microRNA regulates insulin secretion , 2004, Nature.

[74]  J. Rossi,et al.  Post-transcriptional Up-regulation of Tsc-22 by Ybx1, a Target of miR-216a, Mediates TGF-β-induced Collagen Expression in Kidney Cells*♦ , 2010, The Journal of Biological Chemistry.

[75]  Wigard P Kloosterman,et al.  Targeted Inhibition of miRNA Maturation with Morpholinos Reveals a Role for miR-375 in Pancreatic Islet Development , 2007, PLoS biology.

[76]  N. Rajewsky,et al.  MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb , 2007, Cell.

[77]  C. Croce,et al.  MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review , 2012, EMBO molecular medicine.

[78]  Y. Suárez,et al.  Improved repair of dermal wounds in mice lacking microRNA-155 , 2014, Journal of cellular and molecular medicine.

[79]  T. Nilsen,et al.  Mechanisms of microRNA‐mediated gene regulation , 2007, Trends in genetics : TIG.

[80]  D. Valle,et al.  DNA methylation regulates microRNA expression , 2007, Cancer biology & therapy.

[81]  Xiangshan Fan,et al.  Up-regulation of Ago2 expression in gastric carcinoma , 2013, Medical Oncology.

[82]  Aaron N. Chang,et al.  Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. , 2011, The Journal of clinical investigation.

[83]  P. Doevendans,et al.  Inhibition of miR-25 Improves Cardiac Contractility in the Failing Heart , 2014, Nature.

[84]  R. Regazzi,et al.  Circulating microRNAs as novel biomarkers for diabetes mellitus , 2013, Nature Reviews Endocrinology.

[85]  Y. Yatabe,et al.  A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. , 2005, Cancer research.

[86]  C. Burge,et al.  Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification. , 2004, RNA.

[87]  G. Ling,et al.  Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating miR-192 , 2011, The Journal of pathology.

[88]  M. Hoque,et al.  The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors. , 2014, Cancer research.

[89]  M. Mann,et al.  miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. , 2002, Genes & development.

[90]  C. Croce,et al.  Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[91]  H. Tagawa,et al.  A microRNA cluster as a target of genomic amplification in malignant lymphoma , 2005, Leukemia.

[92]  R. Natarajan,et al.  Distinct Roles of Heterogeneous Nuclear Ribonuclear Protein K and microRNA-16 in Cyclooxygenase-2 RNA Stability Induced by S100b, a Ligand of the Receptor for Advanced Glycation End Products*♦ , 2008, Journal of Biological Chemistry.

[93]  G. Hirokawa,et al.  Plasma miR-208 as a biomarker of myocardial injury. , 2009, Clinical chemistry.

[94]  C. Croce,et al.  MicroRNA-133 controls cardiac hypertrophy , 2007, Nature Medicine.

[95]  Mingyu Liang,et al.  MicroRNA-target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis. , 2008, Genome research.

[96]  Khosrow Adeli,et al.  Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. , 2002, Endocrine reviews.

[97]  C. Croce,et al.  microRNA involvement in human cancer. , 2012, Carcinogenesis.

[98]  T. Okanoue,et al.  Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues , 2006, Oncogene.

[99]  Uyen Tran,et al.  The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity , 2010, Development.

[100]  V. Erdmann,et al.  Long-Term Cardiac-Targeted RNA Interference for the Treatment of Heart Failure Restores Cardiac Function and Reduces Pathological Hypertrophy , 2009, Circulation.

[101]  Yariv Yogev,et al.  Serum MicroRNAs Are Promising Novel Biomarkers , 2008, PloS one.

[102]  C. Croce,et al.  Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA , 2012, Proceedings of the National Academy of Sciences.

[103]  Merlin C. Thomas,et al.  miR-200a Prevents Renal Fibrogenesis Through Repression of TGF-β2 Expression , 2010, Diabetes.

[104]  S. Cohen,et al.  The bantam gene regulates Drosophila growth. , 2002, Genetics.

[105]  B. Cullen,et al.  MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[106]  J. Long,et al.  MicroRNA-29c Is a Signature MicroRNA under High Glucose Conditions That Targets Sprouty Homolog 1, and Its in Vivo Knockdown Prevents Progression of Diabetic Nephropathy* , 2011, The Journal of Biological Chemistry.

[107]  C. Perou,et al.  A custom microarray platform for analysis of microRNA gene expression , 2004, Nature Methods.

[108]  C. Croce,et al.  MicroRNAs and chromosomal abnormalities in cancer cells , 2006, Oncogene.

[109]  Patrick J. Paddison,et al.  Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia , 2010, Nature Cell Biology.

[110]  Yu-Ting Huang,et al.  MicroRNA-29a promotion of nephrin acetylation ameliorates hyperglycemia-induced podocyte dysfunction. , 2014, Journal of the American Society of Nephrology : JASN.

[111]  J. Bertram,et al.  Role of microRNAs in kidney homeostasis and disease. , 2012, Kidney international.

[112]  S. Chakrabarti,et al.  MicroRNAs: the underlying mediators of pathogenetic processes in vascular complications of diabetes. , 2013, Canadian journal of diabetes.

[113]  M. Latronico,et al.  microRNAs in cardiovascular diseases: current knowledge and the road ahead. , 2014, Journal of the American College of Cardiology.

[114]  N. Baroukh,et al.  MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic β-Cell Lines* , 2007, Journal of Biological Chemistry.

[115]  Seongjoon Koo,et al.  Development of a micro-array to detect human and mouse microRNAs and characterization of expression in human organs. , 2004, Nucleic acids research.

[116]  A. Aravin,et al.  Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline , 2001, Current Biology.

[117]  Z. Mbita,et al.  The Role of MicroRNAs in Kidney Disease , 2015, Non-coding RNA.

[118]  M. Zavolan,et al.  MicroRNAs 103 and 107 regulate insulin sensitivity , 2011, Nature.

[119]  B. Cullen,et al.  Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. , 2003, Genes & development.

[120]  F. K. Knop,et al.  GLP-1 and Amylin in the Treatment of Obesity , 2015, Current Diabetes Reports.

[121]  Yong Zhao,et al.  Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis , 2005, Nature.

[122]  L. O’Driscoll,et al.  Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells. , 2010, Biochemical and biophysical research communications.

[123]  C. Fernández-Hernando,et al.  MicroRNAs and Atherosclerosis , 2013, Current Atherosclerosis Reports.

[124]  F. Lo‐Coco,et al.  Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein. , 2007, Cancer cell.

[125]  T. Zeller,et al.  microRNA-based diagnostics and therapy in cardiovascular disease-Summing up the facts. , 2015, Cardiovascular diagnosis and therapy.

[126]  Yanjie Lu,et al.  MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts. , 2011, The Journal of Biological Chemistry.

[127]  Andrea Sacconi,et al.  Epigenetic silencing of miR-145-5p contributes to brain metastasis , 2015, Oncotarget.

[128]  Jian-Fu Chen,et al.  The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation , 2006, Nature Genetics.

[129]  H. Trompeter,et al.  Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells , 2010, BMC Research Notes.

[130]  J. Mendell,et al.  Myc: Maestro of MicroRNAs. , 2010, Genes & cancer.

[131]  Michael T. McManus,et al.  IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2 , 2012, Science.

[132]  D. Bartel.  MicroRNAs: Target Recognition and Regulatory Functions , 2009, Cell.

[133]  S. Chakrabarti,et al.  miR-195 regulates SIRT1-mediated changes in diabetic retinopathy , 2014, Diabetologia.

[134]  V. Mohan,et al.  Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes , 2011, Molecular and Cellular Biochemistry.

[135]  Jan A Staessen,et al.  Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease , 2010, Circulation. Cardiovascular genetics.

[136]  E. Izaurralde,et al.  Getting to the Root of miRNA-Mediated Gene Silencing , 2008, Cell.

[137]  R. Qian,et al.  MicroRNA‐320 EXPRESSION IN MYOCARDIAL MICROVASCULAR ENDOTHELIAL CELLS AND ITS RELATIONSHIP WITH INSULIN‐LIKE GROWTH FACTOR‐1 IN TYPE 2 DIABETIC RATS , 2009, Clinical and experimental pharmacology & physiology.

[138]  Nilesh J Samani,et al.  MicroRNAs in cardiovascular disease: an introduction for clinicians , 2015, Heart.

[139]  Arunmozhiarasi Armugam,et al.  MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus , 2011, PloS one.

[140]  S. Ropero,et al.  A microRNA DNA methylation signature for human cancer metastasis , 2008, Proceedings of the National Academy of Sciences.

[141]  D. Karolina,et al.  MicroRNA 320a Functions as a Novel Endogenous Modulator of Aquaporins 1 and 4 as Well as a Potential Therapeutic Target in Cerebral Ischemia* , 2010, The Journal of Biological Chemistry.

[142]  Q. Mi,et al.  The regulation and function of micrornas in kidney diseases , 2013, IUBMB life.

[143]  N. Baroukh,et al.  miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells , 2008, Diabetes.

[144]  M. Esteller,et al.  CpG island hypermethylation of tumor suppressor microRNAs in human cancer. , 2007 .

[145]  Benedikt Brors,et al.  Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease , 2008, BMC Genomics.

[146]  Xabier Agirre,et al.  Epigenetic regulation of microRNA expression in colorectal cancer , 2009, International journal of cancer.

[147]  R. Stephens,et al.  Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. , 2006, Cancer cell.

[148]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[149]  Michael Z Michael,et al.  Reduced accumulation of specific microRNAs in colorectal neoplasia. , 2003, Molecular cancer research : MCR.

[150]  X. Chen,et al.  Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases , 2008, Cell Research.

[151]  Yanjie Lu,et al.  MicroRNA miR-133 Represses HERG K+ Channel Expression Contributing to QT Prolongation in Diabetic Hearts* , 2007, Journal of Biological Chemistry.

[152]  Jacqueline Ho,et al.  Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. , 2008, Journal of the American Society of Nephrology : JASN.

[153]  Guihua Sun,et al.  Interplay between HIV-1 infection and host microRNAs , 2011, Nucleic acids research.

[154]  Xiao-ming Meng,et al.  miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes , 2013, Diabetologia.

[155]  Bruce A. Hay,et al.  The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism , 2003, Current Biology.

[156]  Min Xu,et al.  Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study , 2011, Acta Diabetologica.

[157]  M. Martínez-Larrad,et al.  Serum Circulating microRNA Profiling for Identification of Potential Type 2 Diabetes and Obesity Biomarkers , 2013, PloS one.

[158]  G. Goodall,et al.  E-Cadherin Expression Is Regulated by miR-192/215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor-β , 2010, Diabetes.

[159]  J. Weiler,et al.  Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? , 2006, Gene Therapy.

[160]  Guang-xiu Lu,et al.  Over-expression of miR375 reduces glucose-induced insulin secretion in Nit-1 cells , 2011, Molecular Biology Reports.

[161]  R. Russell,et al.  bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila , 2003, Cell.

[162]  E. Olson,et al.  MicroRNAs add a new dimension to cardiovascular disease. , 2010, Circulation.

[163]  Tara L. Naylor,et al.  microRNAs exhibit high frequency genomic alterations in human cancer. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[164]  R. Quigg,et al.  MicroRNA‐377 is up‐regulated and can lead to increased fibronectin production in diabetic nephropathy , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[165]  Gang Wang,et al.  Urinary miR-21, miR-29, and miR-93: Novel Biomarkers of Fibrosis , 2012, American Journal of Nephrology.

[166]  T. Boettger,et al.  Induction of angiotensin-converting enzyme after miR-143/145 deletion is critical for impaired smooth muscle contractility. , 2014, American journal of physiology. Cell physiology.

[167]  Michael T. McManus,et al.  Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. , 2008, Journal of the American Society of Nephrology : JASN.

[168]  O. Liew,et al.  MicroRNA and Heart Failure , 2016, International journal of molecular sciences.

[169]  M. Mayr,et al.  MicroRNAs in Cardiovascular Disease. , 2016, Journal of the American College of Cardiology.