Decreased conflict- and error-related activity in the anterior cingulate cortex in subjects with schizophrenia.

OBJECTIVE People with schizophrenia have exhibited reduced functional activity in the anterior cingulate cortex during the performance of many types of cognitive tasks and during the commission of errors. According to conflict theory, the anterior cingulate cortex is involved in the monitoring of response conflict, acting as a signal for a need for greater cognitive control. This study examined whether impaired conflict monitoring in people with schizophrenia could underlie reduced anterior cingulate activity during both correct task performance and error-related activity. METHOD Functional activity in the anterior cingulate of 13 schizophrenia patients and 13 healthy comparison subjects was investigated by using event-related fMRI and a Stroop task that allowed simultaneous examination of activity during both conflict (incongruent trials) and error (commission of error trials). RESULTS In the presence of comparable reaction time measures for conflict as well as comparable error rates, the schizophrenia subjects showed both decreased conflict- and error-related activity in the same region of the anterior cingulate cortex. Moreover, those with schizophrenia did not exhibit significant post-conflict or post-error behavioral adjustments. CONCLUSIONS Concurrently reduced conflict- and error-related activity in the anterior cingulate cortex along with reduced trial-to-trial adjustments in performance has not previously been reported in schizophrenia. The current results suggest that impaired conflict monitoring by the anterior cingulate cortex might play an important role in contributing to cognitive control deficits in patients with schizophrenia.

[1]  C. Frith,et al.  The positive and negative symptoms of schizophrenia reflect impairments in the perception and initiation of action , 1987, Psychological Medicine.

[2]  J. Cohen,et al.  Context, cortex, and dopamine: a connectionist approach to behavior and biology in schizophrenia. , 1992, Psychological review.

[3]  E. Donchin,et al.  Optimizing the use of information: strategic control of activation of responses. , 1992, Journal of experimental psychology. General.

[4]  W T Carpenter,et al.  Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. , 1992, Archives of general psychiatry.

[5]  D. Meyer,et al.  A Neural System for Error Detection and Compensation , 1993 .

[6]  Jonathan D. Cohen,et al.  Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size Threshold , 1995, Magnetic resonance in medicine.

[7]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[8]  M. Botvinick,et al.  Anterior cingulate cortex, error detection, and the online monitoring of performance. , 1998, Science.

[9]  Scott T. Grafton,et al.  Automated image registration: I. General methods and intrasubject, intramodality validation. , 1998, Journal of computer assisted tomography.

[10]  B. Kopp,et al.  An event-related brain potential substrate of disturbed response monitoring in paranoid schizophrenic patients. , 1999, Journal of abnormal psychology.

[11]  A M Dale,et al.  Optimal experimental design for event‐related fMRI , 1999, Human brain mapping.

[12]  D. Braff,et al.  Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the "right stuff"? , 2000, Schizophrenia bulletin.

[13]  J. Hohnsbein,et al.  ERP components on reaction errors and their functional significance: a tutorial , 2000, Biological Psychology.

[14]  J. Cohen,et al.  Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. , 2000, Science.

[15]  T. Braver,et al.  Anterior Cingulate Cortex and Response Conflict : Effects of Response Modality and Processing Domain , 2022 .

[16]  M. Botvinick,et al.  Conflict monitoring and cognitive control. , 2001, Psychological review.

[17]  C. Carter,et al.  Anterior cingulate cortex activity and impaired self-monitoring of performance in patients with schizophrenia: an event-related fMRI study. , 2001, The American journal of psychiatry.

[18]  D. V. Cramon,et al.  Subprocesses of Performance Monitoring: A Dissociation of Error Processing and Response Competition Revealed by Event-Related fMRI and ERPs , 2001, NeuroImage.

[19]  Katya Rubia,et al.  An fMRI study of reduced left prefrontal activation in schizophrenia during normal inhibitory function , 2001, Schizophrenia Research.

[20]  J B Poline,et al.  Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. , 2001, The American journal of psychiatry.

[21]  T. Braver,et al.  Anterior cingulate cortex and response conflict: effects of response modality and processing domain. , 2001, Cerebral Cortex.

[22]  T. Braver,et al.  Anterior cingulate cortex and response conflict: effects of frequency, inhibition and errors. , 2001, Cerebral cortex.

[23]  Claude Alain,et al.  Neurophysiological evidence of error-monitoring deficits in patients with schizophrenia. , 2002, Cerebral cortex.

[24]  C. Carter,et al.  The Timing of Action-Monitoring Processes in the Anterior Cingulate Cortex , 2002, Journal of Cognitive Neuroscience.

[25]  K. Kiehl,et al.  Error-related negativity and correct response negativity in schizophrenia , 2002, Clinical Neurophysiology.

[26]  S. Tanada,et al.  Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia. , 2002, Archives of general psychiatry.

[27]  J. Ford,et al.  Response-monitoring dysfunction in schizophrenia: an event-related brain potential study. , 2002, Journal of abnormal psychology.

[28]  K. Kiehl,et al.  Rostral anterior cingulate cortex dysfunction during error processing in schizophrenia. , 2003, Brain : a journal of neurology.

[29]  Walter Schneider,et al.  Fiswidgets - A graphical computing environment for neuroimaging analysis , 2003, Neuroinformatics.

[30]  E. Awh,et al.  Conflict adaptation effects in the absence of executive control , 2003, Nature Neuroscience.

[31]  J. Ford,et al.  Anatomy of an error: ERP and fMRI , 2003, Biological Psychology.

[32]  Stephan Felber,et al.  An FMRI study of episodic encoding and recognition of words in patients with schizophrenia in remission. , 2003, The American journal of psychiatry.

[33]  H. Berenbaum,et al.  The relationship between formal thought disorder and executive functioning component processes. , 2003, Journal of abnormal psychology.

[34]  Jonathan D. Cohen,et al.  Anterior Cingulate Conflict Monitoring and Adjustments in Control , 2004, Science.