In vivo genotoxicity of alcohol consumption and lead exposure in printing press workers.

The objective of the present study was to evaluate the genotoxicity of a double exposure to alcohol and lead in subjects from the printing industry, and the possible interaction between the two agents. Individuals were classified into four different groups: controls, lead-exposed individuals, alcohol consumers, and lead-exposed alcohol consumers. Chromosomal analysis was carried out according to conventional methods and data on chromosome aberrations and sister chromatid exchanges (SCEs) were obtained for each individual. Alcohol consumers had a significant increase in the frequency of SCEs compared to the controls. Though there was an increase in the frequency of chromosome aberrations and SCEs in individuals exposed to lead, it was not significant. Statistical analysis did not reveal an interaction between alcohol and lead in either assay.

[1]  P. Infante,et al.  Living in a chemical world: actions and reactions to industrial carcinogens. , 1988, Teratogenesis, carcinogenesis, and mutagenesis.

[2]  S. Nordström,et al.  Occupational and environmental risks in and around a smelter in northern Sweden. IV. Chromosomal aberrations in workers exposed to lead. , 2009, Hereditas.

[3]  W. W. Nichols,et al.  Sister-chromatid exchange (SCE) report on control subjects in a study of occupationally exposed workers. , 1984, Mutation research.

[4]  C. Halsted.  Folate deficiency in alcoholism. , 1980, The American journal of clinical nutrition.

[5]  M. Bauchinger,et al.  Chromosome analyses of children after ecological lead exposure. , 1977, Mutation research.

[6]  S. Wolff,et al.  New Giemsa method for the differential staining of sister chromatids , 1974, Nature.

[7]  I J Selikoff,et al.  ASBESTOS EXPOSURE, CIGARETTE SMOKING AND DEATH RATES * , 1979, Annals of the New York Academy of Sciences.

[8]  H. Hamamy,et al.  Chromosome aberrations in workers at a storage battery plant in Iraq. , 1986, Mutation research.

[9]  M. Bauchinger,et al.  Chromosome aberrations in lymphocytes after occupational exposure to lead and cadmium. , 1976, Mutation research.

[10]  G. Obe,et al.  Acetaldehyde induces cross-links in DNA and causes sister-chromatid exchanges in human cells. , 1978, Mutation research.

[11]  Diana Anderson,et al.  Genetic effects of ethanol , 1987 .

[12]  C Winder,et al.  The genotoxicity of lead. , 1993, Mutation research.

[13]  P. Nowell,et al.  Chromosome preparations of leukocytes cultured from human peripheral blood. , 1960, Experimental cell research.

[14]  A. Natarajan,et al.  Chromosomal aberrations in peripheral lymphocytes of alcoholics. , 1980, Mutation research.

[15]  J. Reidy,et al.  Increased chromosome fragility as a consequence of blood folate levels, smoking status, and coffee consumption , 1989, Environmental and molecular mutagenesis.

[16]  I. Sbrana,et al.  Chromosomal aberration analysis of workers in tannery industries. , 1991, Mutation research.