A review on biodegradable polymeric materials for bone tissue engineering applications

Biodegradable polymer scaffolds have played a significant role in wide range of tissue engineering application such as bone scaffolds since the last decade. The aim of this article is to provide the comprehensive overview of biocompatible and biodegradable polymer materials and composite materials with their advantages and drawbacks in the application of biomaterial scaffolds, furthermore the properties and degradation criteria of the biomaterials are discussed in this review.

[1]  T. Park,et al.  Dexamethasone-releasing biodegradable polymer scaffolds fabricated by a gas-foaming/salt-leaching method. , 2003, Biomaterials.

[2]  Cato T Laurencin,et al.  Polyphosphazene/nano-hydroxyapatite composite microsphere scaffolds for bone tissue engineering. , 2008, Biomacromolecules.

[3]  Guoping Chen,et al.  Scaffold Design for Tissue Engineering , 2002 .

[4]  Y Ikada,et al.  Fabrication of porous gelatin scaffolds for tissue engineering. , 1999, Biomaterials.

[5]  Xuesi Chen,et al.  Co-electrospun poly(lactide-co-glycolide), gelatin, and elastin blends for tissue engineering scaffolds. , 2006, Journal of biomedical materials research. Part A.

[6]  A R Boccaccini,et al.  Porous poly(alpha-hydroxyacid)/Bioglass composite scaffolds for bone tissue engineering. I: Preparation and in vitro characterisation. , 2004, Biomaterials.

[7]  D. Yao,et al.  Fabrication of polycaprolactone scaffolds using a sacrificial compression-molding process. , 2006, Journal of biomedical materials research. Part B, Applied biomaterials.

[8]  J. Nam,et al.  Effect of PEG-PLLA diblock copolymer on macroporous PLLA scaffolds by thermally induced phase separation. , 2004, Biomaterials.

[9]  S. Ramakrishna,et al.  Biomedical applications of polymer-composite materials: a review , 2001 .

[10]  C T Laurencin,et al.  Biodegradable polyphosphazenes for drug delivery applications. , 2003, Advanced drug delivery reviews.

[11]  Joseph Kost,et al.  Handbook of Biodegradable Polymers , 1998 .

[12]  W C de Bruijn,et al.  Late degradation tissue response to poly(L-lactide) bone plates and screws. , 1995, Biomaterials.

[13]  J. Callaghan Periprosthetic fractures of the acetabulum during and following total hip arthroplasty. , 1997, Instructional course lectures.

[14]  N. Gadegaard,et al.  3D polymer scaffolds for tissue engineering. , 2006, Nanomedicine.

[15]  Kevin E. Healy,et al.  A novel method to fabricate bioabsorbable scaffolds , 1995 .

[16]  D J Mooney,et al.  Optimizing seeding and culture methods to engineer smooth muscle tissue on biodegradable polymer matrices. , 1998, Biotechnology and bioengineering.

[17]  B. Tighe,et al.  Polymers for biodegradable medical devices. II. Hydroxybutyrate-hydroxyvalerate copolymers: hydrolytic degradation studies. , 1987, Biomaterials.

[18]  I H Kalfas,et al.  Principles of bone healing. , 2001, Neurosurgical focus.

[19]  David Hui,et al.  A critical review on polymer-based bio-engineered materials for scaffold development , 2007 .

[20]  Colin W. Pouton,et al.  Biosynthetic polyhydroxyalkanoates and their potential in drug delivery , 1996 .

[21]  Peter X Ma,et al.  Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering. , 2004, Biomaterials.

[22]  T. Cheng,et al.  Therapeutic potential of chitosan and its derivatives in regenerative medicine. , 2006, The Journal of surgical research.

[23]  A. Mikos,et al.  In vitro degradation of a poly(propylene fumarate)/β-tricalcium phosphate composite orthopaedic scaffold , 1997 .

[24]  Xavier Roy,et al.  Controlled preparation and properties of porous poly(L-lactide) obtained from a co-continuous blend of two biodegradable polymers. , 2004, Biomaterials.

[25]  H R Allcock,et al.  Use of polyphosphazenes for skeletal tissue regeneration. , 1993, Journal of biomedical materials research.

[26]  Jacqueline I. Kroschwitz,et al.  Encyclopedia of Polymer Science and Technology , 1970 .

[27]  J M Brady,et al.  Degradation rates of oral resorbable implants (polylactates and polyglycolates): rate modification with changes in PLA/PGA copolymer ratios. , 1977, Journal of biomedical materials research.

[28]  Chia-Ying Lin,et al.  Functional bone engineering using ex vivo gene therapy and topology-optimized, biodegradable polymer composite scaffolds. , 2005, Tissue engineering.

[29]  Mário A. Barbosa,et al.  Polysaccharides as scaffolds for bone regeneration , 2005 .

[30]  Sang Ho Cho,et al.  Fabrication and characterization of hydrophilic poly(lactic-co-glycolic acid)/poly(vinyl alcohol) blend cell scaffolds by melt-molding particulate-leaching method. , 2003, Biomaterials.

[31]  Guoqiang Chen,et al.  Polyhydroxyalkanoate (PHA) scaffolds with good mechanical properties and biocompatibility. , 2003, Biomaterials.

[32]  Chrysanthi Williams,et al.  Small-diameter artificial arteries engineered in vitro. , 2005, Circulation research.

[33]  Alyssa Panitch,et al.  Polymeric biomaterials for tissue and organ regeneration , 2001 .

[34]  C T Laurencin,et al.  Preliminary in vivo report on the osteocompatibility of poly(anhydride-co-imides) evaluated in a tibial model. , 1998, Journal of biomedical materials research.

[35]  J. Suh,et al.  Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. , 2000, Biomaterials.

[36]  Heather Sheardown,et al.  Biofunctionalization of collagen for improved biological response: scaffolds for corneal tissue engineering. , 2007, Biomaterials.

[37]  J H Brekke,et al.  Principles of tissue engineering applied to programmable osteogenesis. , 1998, Journal of biomedical materials research.

[38]  D E Ingber,et al.  Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation. , 1993, Journal of biomedical materials research.

[39]  C. Guoqiang,et al.  Effects of surface morphology on the biocompatibility of polyhydroxyalkanoates , 2003 .

[40]  Shen‐guo Wang,et al.  A novel porous cells scaffold made of polylactide-dextran blend by combining phase-separation and particle-leaching techniques. , 2002, Biomaterials.

[41]  C. M. Agrawal,et al.  Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers. , 1996, Biomaterials.

[42]  W. Park,et al.  In vitro degradation behavior of electrospun polyglycolide, polylactide, and poly(lactide‐co‐glycolide) , 2005 .

[43]  Toshihiro Akaike,et al.  A novel degradable polycaprolactone networks for tissue engineering. , 2003, Biomaterials.

[44]  A. Mikos,et al.  Injectable biodegradable materials for orthopedic tissue engineering. , 2000, Biomaterials.

[45]  Cato T Laurencin,et al.  Tissue engineered microsphere-based matrices for bone repair: design and evaluation. , 2002, Biomaterials.

[46]  M. Huneault,et al.  Preparation of interconnected poly(ε-caprolactone) porous scaffolds by a combination of polymer and salt particulate leaching , 2006 .

[47]  Cato T Laurencin,et al.  Polymers as biomaterials for tissue engineering and controlled drug delivery. , 2006, Advances in biochemical engineering/biotechnology.

[48]  Y. Kuo,et al.  Effects of Composition, Solvent, and Salt Particles on the Physicochemical Properties of Polyglycolide/Poly(lactide‐co‐glycolide) Scaffolds , 2006, Biotechnology progress.

[49]  Abraham J Domb,et al.  Polyanhydrides: an overview. , 2002, Advanced drug delivery reviews.

[50]  Antonios G Mikos,et al.  In vitro degradation of porous poly(propylene fumarate)/poly(DL-lactic-co-glycolic acid) composite scaffolds. , 2005, Biomaterials.

[51]  Guoqiang Chen,et al.  The application of polyhydroxyalkanoates as tissue engineering materials. , 2005, Biomaterials.

[52]  S. Glassman,et al.  The Art of Bone Grafting , 2007 .

[53]  M S Chapekar,et al.  Tissue engineering: challenges and opportunities. , 2000, Journal of biomedical materials research.

[54]  H. Allcock Recent developments in polyphosphazene materials science , 2006 .

[55]  C. M. Agrawal,et al.  Biodegradable polymeric scaffolds for musculoskeletal tissue engineering. , 2001, Journal of biomedical materials research.

[56]  Pier Paolo Parnigotto,et al.  In vitro evaluation of poly[bis(ethyl alanato)phosphazene] as a scaffold for bone tissue engineering. , 2006, Tissue engineering.

[57]  Amar K. Mohanty,et al.  Effect of the processing methods on the performance of polylactide films: Thermocompression versus solvent casting , 2006 .

[58]  S. Mann,et al.  The potential of biomimesis in bone tissue engineering: lessons from the design and synthesis of invertebrate skeletons. , 2002, Bone.

[59]  K. Burg,et al.  Biomaterial developments for bone tissue engineering. , 2000, Biomaterials.

[60]  Ralph Müller,et al.  Architecture and properties of anisotropic polymer composite scaffolds for bone tissue engineering. , 2006, Biomaterials.

[61]  J. Hollinger,et al.  Macrophysiologic Roles of a Delivery System for Vulnerary Factors Needed for Bone Regeneration , 1997, Annals of the New York Academy of Sciences.

[62]  S. Shalaby,et al.  Biomedical polymers : designed-to-degrade systems , 1994 .

[63]  Dong-Woo Cho,et al.  Blended PCL/PLGA scaffold fabrication using multi-head deposition system , 2009 .

[64]  Seung Jin Lee,et al.  In vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(l-lactic acid) fibres and porous ultra-fine poly(glycolic acid) fibres , 2005 .

[65]  P. Sambrook,et al.  The musculoskeletal system , 2001 .

[66]  Zbigniew Ruszczak,et al.  Effect of collagen matrices on dermal wound healing. , 2003, Advanced drug delivery reviews.

[67]  A Göpferich,et al.  Polyanhydride degradation and erosion. , 2002, Advanced drug delivery reviews.

[68]  Z. Hashin,et al.  A CUMULATIVE DAMAGE THEORY OF FATIGUE FAILURE , 1978 .

[69]  C. M. Agrawal,et al.  Technique to control pH in vicinity of biodegrading PLA-PGA implants. , 1997, Journal of biomedical materials research.

[70]  K. Anseth,et al.  Crosslinked polyanhydrides for use in orthopedic applications: degradation behavior and mechanics. , 1999, Journal of biomedical materials research.

[71]  L. Téot,et al.  The healing properties of Promogran in venous leg ulcers. , 2002, Journal of wound care.

[72]  T. Park,et al.  A facile preparation of highly interconnected macroporous PLGA scaffolds by liquid–liquid phase separation II , 2005 .

[73]  C. Laurencin,et al.  Controlled macromolecule release from poly(phosphazene) matrices , 1996 .

[74]  N. Washburn,et al.  Structure and mechanical properties of poly(?,?-lactic acid)/poly(ɛ-caprolactone) blends , 2003 .

[75]  Giovanni Vozzi,et al.  Blends of Poly-(ε-caprolactone) and Polysaccharides in Tissue Engineering Applications , 2005 .

[76]  Robert Gurny,et al.  Poly(ortho esters): synthesis, characterization, properties and uses. , 2002, Advanced drug delivery reviews.

[77]  Maryam Tabrizian,et al.  Responses of mesenchymal stem cell to chitosan-coralline composites microstructured using coralline as gas forming agent. , 2006, Biomaterials.

[78]  J C Middleton,et al.  Synthetic biodegradable polymers as orthopedic devices. , 2000, Biomaterials.