The extracellular matrix as a scaffold for tissue reconstruction.

The extracellular matrix (ECM) consists of a complex mixture of structural and functional proteins and serves an important role in tissue and organ morphogenesis, maintenance of cell and tissue structure and function, and in the host response to injury. Xenogeneic and allogeneic ECM has been used as a bioscaffold for the reconstruction of many different tissue types in both pre-clinical and human clinical studies. Common features of ECM-associated tissue remodeling include extensive angiogenesis, recruitment of circulating progenitor cells, rapid scaffold degradation and constructive remodeling of damaged or missing tissues. The ECM-induced remodeling response is a distinctly different phenomenon from that of scar tissue formation.

[1]  S. Badylak,et al.  Porcine small intestinal submucosa as a dural substitute. , 1999, Surgical neurology.

[2]  H. Kleinman,et al.  Identification of endothelial cell binding sites on the laminin γ1 chain , 1999 .

[3]  B. Eppley,et al.  Experimental evaluation of small intestinal submucosa as a microvascular graft material , 1994, Microsurgery.

[4]  S. Badylak,et al.  Glycosaminoglycan content of small intestinal submucosa: a bioscaffold for tissue replacement. , 1996, Tissue engineering.

[5]  W. Reutter,et al.  Collagen type I modulates the platelet-derived growth factor (PDGF) regulation of the growth and expression of beta1 integrins by rat mesangial cells. , 1998, Biochemical and biophysical research communications.

[6]  G. Laurie,et al.  In situ hybridization reveals temporal and spatial changes in cellular expression of mRNA for a laminin receptor, laminin, and basement membrane (type IV) collagen in the developing kidney , 1989, The Journal of cell biology.

[7]  S. Hayward,et al.  Understanding bladder regeneration: smooth muscle ontogeny. , 1999, The Journal of urology.

[8]  H. Kleinman,et al.  Identification of endothelial cell binding sites on the laminin gamma 1 chain. , 1999, Circulation research.

[9]  Thiennu H. Vu,et al.  Matrix‐degrading proteases and angiogenesis during development and tumor formation , 1999, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[10]  S. Badylak,et al.  Detrusor regeneration in the rat using porcine small intestinal submucosal grafts: functional innervation and receptor expression. , 1996, The Journal of urology.

[11]  A. Atala,et al.  A novel inert collagen matrix for hypospadias repair. , 1999, The Journal of urology.

[12]  T F Lue,et al.  IN VITRO FUNCTIONAL PROPERTIES OF THE RAT BLADDER REGENERATED BY THE BLADDER ACELLULAR MATRIX GRAFT , 1998, The Journal of Urology.

[13]  Erkki Ruoslahti,et al.  Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule , 1984, Nature.

[14]  S. Hayward,et al.  Regeneration of bladder urothelium, smooth muscle, blood vessels and nerves into an acellular tissue matrix. , 1996, The Journal of urology.

[15]  S. Badylak,et al.  Healing comparison of small intestine submucosa and ePTFE grafts in the canine carotid artery. , 1995, The Journal of surgical research.

[16]  D. Mooney,et al.  In vitro and In vivo Models for the Reconstruction of Intercellular Signaling a, , 1998, Annals of the New York Academy of Sciences.

[17]  R. Dahiya,et al.  Reproduction of functional smooth muscle tissue and partial bladder replacement. , 1997, British journal of urology.

[18]  R. Dahiya,et al.  Free ureteral replacement in rats: regeneration of ureteral wall components in the acellular matrix graft* , 1997, Urology.

[19]  R. Timpl.  Macromolecular organization of basement membranes. , 1996, Current opinion in cell biology.

[20]  S. Badylak,et al.  Regenerative urinary bladder augmentation using small intestinal submucosa: urodynamic and histopathologic assessment in long-term canine bladder augmentations. , 1996, The Journal of urology.

[21]  S. Badylak,et al.  Marrow-derived cells populate scaffolds composed of xenogeneic extracellular matrix. , 2001, Experimental hematology.

[22]  T F Lue,et al.  Composition and biomechanical properties of the bladder acellular matrix graft: comparative analysis in rat, pig and human. , 1998, British journal of urology.

[23]  K. Yamada,et al.  Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function , 1984, The Journal of cell biology.

[24]  C. Gleason,et al.  Bladder acellular matrix graft: in vivo functional properties of the regenerated rat bladder , 1999, Urological Research.

[25]  S. Badylak,et al.  Characterization of small intestinal submucosa regenerated canine detrusor: assessment of reinnervation, in vitro compliance and contractility. , 1996, The Journal of urology.

[26]  T. Dexter,et al.  Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis , 1988, Nature.

[27]  R. Dahiya,et al.  Homologous bladder augmentation in dog with the bladder acellular matrix graft , 2000, BJU international.

[28]  D J Mooney,et al.  Engineering smooth muscle tissue with a predefined structure. , 1998, Journal of biomedical materials research.

[29]  I. Konigsberg,et al.  The influence of collagen on the development of muscle clones. , 1966, Proceedings of the National Academy of Sciences of the United States of America.

[30]  S. Badylak,et al.  Characterization of Fibronectin Derived from Porcine Small Intestinal Submucosa , 1998 .

[31]  W. Nelson,et al.  Integrin‐mediated calcium signaling and regulation of cell adhesion by intracellular calcium , 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.

[32]  M. Bissell,et al.  From laminin to lamin: regulation of tissue-specific gene expression by the ECM. , 1995, Trends in cell biology.

[33]  N. K. Wessells,et al.  Effects of collagenase on developing epithelia in vitro: lung, ureteric bud, and pancreas. , 1968, Developmental biology.

[34]  D. Ingber.  Extracellular matrix and cell shape: Potential control points for inhibition of angiogenesis , 1991, Journal of cellular biochemistry.

[35]  S. Badylak,et al.  Small Intestinal Submucosa as an Intra-Articular Ligamentous Graft Material: A Pilot Study in Dogs , 1994, Phlebologie.

[36]  C. Gleason,et al.  Bladder acellular matrix graft in rats: Its neurophysiologic properties and mRNA expression of growth factors TGF‐α and TGF‐β , 1998 .

[37]  C. Gleason,et al.  Bladder acellular matrix graft in rats: its neurophysiologic properties and mRNA expression of growth factors TGF-alpha and TGF-beta. , 1998, Neurourology and urodynamics.

[38]  L A Geddes,et al.  Small intestinal submucosa as a large diameter vascular graft in the dog. , 1989, The Journal of surgical research.

[39]  P. Merguerian,et al.  Regeneration of functional bladder substitutes using large segment acellular matrix allografts in a porcine model. , 2000, The Journal of urology.

[40]  R. Timpl,et al.  Supramolecular assembly of basement membranes , 1996, BioEssays : news and reviews in molecular, cellular and developmental biology.

[41]  J. Schwarzbauer.  Basement membrane: Putting up the barriers , 1999, Current Biology.

[42]  P. Merguerian,et al.  Acellular bladder matrix allografts in the regeneration of functional bladders: evaluation of large‐segment (> 24 cm2) substitution in a porcine model , 2000, BJU international.

[43]  S. Badylak,et al.  Small Intestinal Submucosa: Utilization as a Wound Dressing in Full‐Thickness Rodent Wounds , 1995, Annals of plastic surgery.

[44]  J. Schwarzbauer.  Fibronectin: from gene to protein. , 1991, Current opinion in cell biology.

[45]  S. Badylak,et al.  Resorbable bioscaffold for esophageal repair in a dog model. , 2000, Journal of pediatric surgery.

[46]  S. Badylak,et al.  Small intestinal submucosa: a rapidly resorbed bioscaffold for augmentation cystoplasty in a dog model. , 1998, Tissue engineering.

[47]  S. Badylak,et al.  Fibronectin peptides mediate HMEC adhesion to porcine-derived extracellular matrix. , 2002, Biomaterials.

[48]  M. E. van der Rest,et al.  Collagen family of proteins , 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[49]  Allen Wr,et al.  Early embryonic development in the horse. , 1975 .

[50]  M J Bissell,et al.  How does the extracellular matrix direct gene expression? , 1982, Journal of theoretical biology.

[51]  Stephen F. Badylak,et al.  The Effect of Range of Motion on Remodeling of Small Intestinal Submucosa (SIS) When Used as an Achilles Tendon Repair Material in the Rabbit , 1997 .

[52]  A. Atala,et al.  Bladder augmentation using allogenic bladder submucosa seeded with cells. , 1998, Urology.

[53]  S. Badylak.  Modification of Natural Polymers , 2002 .

[54]  T F Lue,et al.  Functional rat bladder regeneration through xenotransplantation of the bladder acellular matrix graft. , 1998, British journal of urology.

[55]  S. Badylak,et al.  Histology after dural grafting with small intestinal submucosa. , 1996, Surgical neurology.

[56]  Kenneth M. Yamada,et al.  Fibronectin and Integrins in Cell Adhesion, Signaling, and Morphogenesis , 1998, Annals of the New York Academy of Sciences.

[57]  Kenneth M. Yamada,et al.  Matrix Receptors in Cell Migration , 1991 .

[58]  A. Atala,et al.  ACELLULAR COLLAGEN MATRIX AS AN "OFF THE SHELF" BIOMATERIAL FOR URETHRAL REPAIR , 1999 .

[59]  L. Bonewald.  Regulation and regulatory activities of transforming growth factor beta. , 1999, Critical reviews in eukaryotic gene expression.