Cimoxatone Is a Reversible Tight‐Binding Inhibitor of the A Form of Rat Brain Monoamine Oxidase

Abstract: Cimoxatone is a fully reversible inhibitor selective for the A form of monoamine oxidase. The inhibition is so potent against this enzyme form that it acts as a tight‐binding inhibitor. Use of this inhibitor indicates that in rat brain homogenates the concentration of monoamine oxidase A is approximately 8–11 pmol‐mg protein−1. Values similar to this were obtained by clor‐gyline titration and both methods gave values similar to those found with a [3H]harmaline binding assay.