USP20 mitigates ischemic stroke in mice by suppressing neuroinflammation and neuron death via regulating PTEN signal.

[1]  Q. Su,et al.  Knockdown lncRNA NEAT1 regulates the activation of microglia and reduces AKT signaling and neuronal apoptosis after cerebral ischemic reperfusion , 2020, Scientific Reports.

[2]  Zhijun Zhang,et al.  Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia , 2020, Journal of neuroinflammation.

[3]  B. Gaire,et al.  BMS-986020, a Specific LPA1 Antagonist, Provides Neuroprotection against Ischemic Stroke in Mice , 2020, Antioxidants.

[4]  Zhen-Lang Lin,et al.  LXA4 protects against hypoxic-ischemic damage in neonatal rats by reducing the inflammatory response via the IκB/NF-κB pathway. , 2020, International immunopharmacology.

[5]  Peng-Fei Wei,et al.  Pharmacological Targeting of CSF1R Inhibits Microglial Proliferation and Aggravates the Progression of Cerebral Ischemic Pathology , 2020, Frontiers in Cellular Neuroscience.

[6]  X. Jia,et al.  Optimizing Stem Cell Therapy after Ischemic Brain Injury , 2020, Journal of stroke.

[7]  G. Song,et al.  Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NF-κB Signaling Pathway , 2020, Frontiers in Neuroscience.

[8]  C. Iadecola,et al.  Immune responses to stroke: mechanisms, modulation, and therapeutic potential. , 2020, The Journal of clinical investigation.

[9]  S. Park,et al.  The Deubiquitinating Enzyme USP20 Regulates the TNFα-Induced NF-κB Signaling Pathway through Stabilization of p62 , 2020, International journal of molecular sciences.

[10]  Wugang Hou,et al.  Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte , 2020, Journal of Neuroinflammation.

[11]  T. Ijuin Phosphoinositide phosphatases in cancer cell dynamics-Beyond PI3K and PTEN. , 2019, Seminars in cancer biology.

[12]  Cheng Huang,et al.  PTEN negatively regulates the expression of pro-inflammatory cytokines and chemokines of fibroblast-like synoviocytes in adjuvant-induced arthritis , 2019, Artificial cells, nanomedicine, and biotechnology.

[13]  G. Citerio,et al.  Acute ischaemic stroke: challenges for the intensivist , 2019, Intensive Care Medicine.

[14]  C. Kong,et al.  USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer , 2019, Journal of Experimental & Clinical Cancer Research.

[15]  M. Luo,et al.  USP20 Promotes Cellular Antiviral Responses via Deconjugating K48-Linked Ubiquitination of MITA , 2019, The Journal of Immunology.

[16]  C. Zhang,et al.  Neutrophil Membrane-Derived Nanovesicles Alleviate Inflammation To Protect Mouse Brain Injury from Ischemic Stroke. , 2019, ACS nano.

[17]  H. Rockman,et al.  The deubiquitinase ubiquitin–specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling , 2018, The Journal of Biological Chemistry.

[18]  K. Lambertsen,et al.  Post-stroke inflammation—target or tool for therapy? , 2018, Acta Neuropathologica.

[19]  S. Shenoy,et al.  USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis , 2018, Arteriosclerosis, thrombosis, and vascular biology.

[20]  Z. Lou,et al.  USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization , 2018, Cell Death & Differentiation.

[21]  S. Park,et al.  The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation , 2018, EMBO reports.

[22]  Y. Shang,et al.  Epigallocatechin-3-gallate inhibits inflammation and epithelial-mesenchymal transition through the PI3K/AKT pathway via upregulation of PTEN in asthma , 2017, International journal of molecular medicine.

[23]  Yan Wang,et al.  Myosin IIA-related Actomyosin Contractility Mediates Oxidative Stress-induced Neuronal Apoptosis , 2017, Front. Mol. Neurosci..

[24]  Y. Wen,et al.  1H, 13C and 15N backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2 , 2017, Biomolecular NMR assignments.

[25]  Sang-oh Han,et al.  Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation* , 2016, The Journal of Biological Chemistry.

[26]  Ivan Dikic,et al.  Ubiquitination in disease pathogenesis and treatment , 2014, Nature Medicine.

[27]  Z. Lou,et al.  HERC2-USP20 axis regulates DNA damage checkpoint through Claspin , 2014, Nucleic acids research.

[28]  Jin Tan,et al.  miR-21 alleviated apoptosis of cortical neurons through promoting PTEN-Akt signaling pathway in vitro after experimental traumatic brain injury , 2014, Brain Research.

[29]  Ping-Yen Liu,et al.  Rho-Kinase Inhibitor, Fasudil, Prevents Neuronal Apoptosis via the Akt Activation and PTEN Inactivation in the Ischemic Penumbra of Rat Brain , 2012, Cellular and Molecular Neurobiology.

[30]  M. Dai,et al.  Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1 , 2012, The EMBO journal.

[31]  Amith Panner,et al.  Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme. , 2010, Cancer research.

[32]  R. D'Hooge,et al.  Applications of the Morris water maze in the study of learning and memory , 2001, Brain Research Reviews.

[33]  J. Garcìa,et al.  Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. , 1995, Stroke.