Reversal of liver failure using a bioartificial liver device implanted with clinical-grade human-induced hepatocytes.

[1]  J. Søreide,et al.  Post hepatectomy liver failure (PHLF) - Recent advances in prevention and clinical management. , 2020, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[2]  G. Michalopoulos,et al.  Liver regeneration: biological and pathological mechanisms and implications , 2020, Nature Reviews Gastroenterology & Hepatology.

[3]  Hexin Yan,et al.  An extracorporeal bioartificial liver embedded with 3D-layered human liver progenitor-like cells relieves acute liver failure in pigs , 2020, Science Translational Medicine.

[4]  E. O'Duibhir,et al.  Alternatively activated macrophages promote resolution of necrosis following acute liver injury , 2020, Journal of hepatology.

[5]  Xiaolei Shi,et al.  Hepatic spheroids derived from human induced pluripotent stem cells in bio-artificial liver rescue porcine acute liver failure , 2019, Cell Research.

[6]  Liu Wang,et al.  Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions , 2019, Cell Death & Disease.

[7]  T. Ochiya,et al.  Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes , 2019, bioRxiv.

[8]  Yohan Kim,et al.  Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells. , 2019, Journal of hepatology.

[9]  W. Kremers,et al.  Randomized Trial of Spheroid Reservoir Bioartificial Liver in Porcine Model of Posthepatectomy Liver Failure , 2018, Hepatology.

[10]  L. Hui,et al.  In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity. , 2018, Cell stem cell.

[11]  Xu Zhou,et al.  Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens , 2018, Cell Research.

[12]  Yaming Li,et al.  Guidelines for Diagnosis and Treatment of Primary Liver Cancer in China (2017 Edition) , 2018, Liver Cancer.

[13]  J. Bruix,et al.  Hepatocellular carcinoma , 2018, The Lancet.

[14]  L. Hui,et al.  Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor , 2017, Stem cell reports.

[15]  U. Neumann,et al.  The ALPPS Risk Score: Avoiding Futile Use of ALPPS , 2016, Annals of surgery.

[16]  L. Hui,et al.  Hepatocellular carcinoma repression by TNFα‐mediated synergistic lethal effect of mitosis defect‐induced senescence and cell death sensitization , 2016, Hepatology.

[17]  L. Hui,et al.  Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes , 2016, Cell Research.

[18]  L. Vallier,et al.  Potential of human induced pluripotent stem cells in studies of liver disease , 2015, Hepatology.

[19]  Steven L Salzberg,et al.  HISAT: a fast spliced aligner with low memory requirements , 2015, Nature Methods.

[20]  D. R. Aldridge,et al.  Pathogenesis of hepatic encephalopathy: role of ammonia and systemic inflammation. , 2015, Journal of clinical and experimental hepatology.

[21]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[22]  J. Seppen,et al.  Bioartificial livers in vitro and in vivo: tailoring biocomponents to the expanding variety of applications , 2014, Expert opinion on biological therapy.

[23]  Paul Theodor Pyl,et al.  HTSeq—a Python framework to work with high-throughput sequencing data , 2014, bioRxiv.

[24]  G. Kouraklis,et al.  Indications, limitations and maneuvers to enable extended hepatectomy: current trends. , 2014, World journal of gastroenterology.

[25]  Ying Zhang,et al.  Direct reprogramming of human fibroblasts to functional and expandable hepatocytes. , 2014, Cell stem cell.

[26]  Jun Jia,et al.  Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming. , 2014, Cell stem cell.

[27]  M. Makuuchi.  Surgical treatment for HCC--special reference to anatomical resection. , 2013, International journal of surgery.

[28]  Gerile Wuyun,et al.  Management of post-hepatectomy complications. , 2013, World journal of gastroenterology.

[29]  D. Raptis,et al.  Liver failure after extended hepatectomy in mice is mediated by a p21-dependent barrier to liver regeneration. , 2012, Gastroenterology.

[30]  S. Nyberg.  Bridging the gap: Advances in artificial liver support , 2012, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[31]  P. Clavien,et al.  Playing Play-Doh to prevent postoperative liver failure: the "ALPPS" approach. , 2012, Annals of surgery.

[32]  David R. Kelley,et al.  Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks , 2012, Nature Protocols.

[33]  K. Kalimeris,et al.  Development of a porcine model of post-hepatectomy liver failure. , 2011, The Journal of surgical research.

[34]  Jürgen Weitz,et al.  Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). , 2011, Surgery.

[35]  D. Stolz,et al.  Rescue of lethal hepatic failure by hepatized lymph nodes in mice. , 2011, Gastroenterology.

[36]  C. Legallais,et al.  Artificial and bioartificial liver devices: present and future , 2009, Gut.

[37]  B. Zeng,et al.  Bama miniature pigs (Sus scrofa domestica) as a model for drug evaluation for humans: comparison of in vitro metabolism and in vivo pharmacokinetics of lovastatin. , 2008, Comparative medicine.

[38]  R. Chamuleau,et al.  Bioartificial Liver: Its Pros and Cons , 2006, Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.

[39]  R. Margreiter,et al.  Extended Liver Resection and Hepatic Ischemia in Pigs: A New, Potentially ReversibleModel to Induce Acute Liver Failure and Study Artificial Liver Support Systems , 2005, European Surgical Research.

[40]  Mauro Salizzoni,et al.  Prospective, Randomized, Multicenter, Controlled Trial of a Bioartificial Liver in Treating Acute Liver Failure , 2004, Annals of surgery.

[41]  L. Ridolfi,et al.  First Report of Cryopreserved Human Hepatocytes Based Bioartificial Liver Successfully Used as a Bridge to Liver Transplantation , 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[42]  P. Neuhaus,et al.  Extracorporeal liver support based on primary human liver cells and albumin dialysis--treatment of a patient with primary graft non-function. , 2003, Journal of hepatology.

[43]  A R Dennison,et al.  Segmental nature of the porcine liver and its potential as a model for experimental partial hepatectomy , 2003, The British journal of surgery.

[44]  Philippe Ichai,et al.  Neurological improvement during bioartificial liver sessions in patients with acute liver failure awaiting transplantation. , 2002, Transplantation.

[45]  G. Mazariegos,et al.  Safety Observations in Phase I Clinical Evaluation of the Excorp Medical Bioartificial Liver Support System after the First Four Patients , 2001, ASAIO journal.

[46]  M. Manns,et al.  Hyperstimulation With Interleukin 6 Inhibits Cell Cycle Progression After Hepatectomy in Mice , 2000, Hepatology.

[47]  K Watanabe,et al.  Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[48]  J. Zucman‐Rossi,et al.  Hepatocellular carcinoma , 1998, Nature Reviews Disease Primers.

[49]  K. Ishak,et al.  Histological grading and staging of chronic hepatitis. , 1995 .

[50]  K. Sugimachi,et al.  Acute portal hypertension associated with liver resection. Analysis of early postoperative death. , 1985, Archives of surgery.

[51]  G. Maddern,et al.  Subtotal hepatectomy: a porcine model for the study of liver regeneration. , 2004, The Journal of surgical research.

[52]  JoVE Video Dataset , 2022 .