The Varicocele: Clinical Presentation, Evaluation, and Surgical Management

Abstract A varicocele is an abnormal dilatation and tortuosity of the veins of the spermatic cord. Although varicoceles are common in the general population and are frequently found on routine physical examinations, they represent the most common correctable cause of male factor infertility. Varicoceles are also often incidental findings on imaging studies, particularly scrotal ultrasound. Importantly, not all varicoceles should be treated equally (or at all), and basic guidelines on the evaluation and indications for treatment of adult varicoceles should be reviewed before counseling and treatment. A semen analysis should be obtained for any male patient of reproductive age considering intervention. The adolescent varicocele is managed much differently than the adult varicocele and remains a source of controversy. This review describes the clinical presentation and the evaluation of adult and pediatric varicoceles, and provides guidance on their diagnosis and workup. It also describes options for surgical repair and the success and complication rates associated with each surgical approach, ultimately supporting microsurgical subinguinal varicocele repair as the current surgical standard.

[1]  J. Gitlin,et al.  Barriers to use of semen analysis in the adolescent with a varicocele: Survey of patient, parental, and practitioner attitudes. , 2016, Journal of pediatric urology.

[2]  D. Lamb,et al.  The varicocele: diagnostic dilemmas, therapeutic challenges and future perspectives , 2015, Asian journal of andrology.

[3]  T. Kolon Evaluation and Management of the Adolescent Varicocele. , 2015, The Journal of urology.

[4]  Hongyan Li,et al.  Microscopic Retroperitoneal Varicocelectomy With Artery and Lymphatic Sparing: An Alternative Treatment for Varicocele in Infertile Men. , 2015, Urology.

[5]  S. Bauer,et al.  Semen parameters in adolescents with varicocele: association with testis volume differential and total testis volume. , 2015, The Journal of urology.

[6]  S. Cho,et al.  Usefulness of 2010 world health organization reference values for determining indications for varicocelectomy. , 2015, Urology.

[7]  Jun Wang,et al.  Inguinal and subinguinal micro-varicocelectomy, the optimal surgical management of varicocele: a meta-analysis , 2014, Asian journal of andrology.

[8]  H. Mosli,et al.  Effects of varicocele on serum testosterone and changes of testosterone after varicocelectomy: a prospective controlled study. , 2014, Urology.

[9]  Puneet Masson,et al.  The varicocele. , 2014, Urologic clinics of North America.

[10]  Report on varicocele and infertility: a committee opinion. , 2014, Fertility and sterility.

[11]  Aixia Zhang,et al.  Comparison of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males , 2013, Urologia Internationalis.

[12]  M. Goldstein,et al.  Varicocelectomy is associated with increases in serum testosterone independent of clinical grade. , 2011, Urology.

[13]  Zhiping Wang,et al.  Open non‐microsurgical, laparoscopic or open microsurgical varicocelectomy for male infertility: a meta‐analysis of randomized controlled trials , 2012, BJU international.

[14]  M. Fujisawa,et al.  Effect of varicocelectomy on testicular volume in children and adolescents: a meta-analysis. , 2012, Urology.

[15]  Waleed Asker,et al.  Varicocelectomy to Treat Pain, and Predictors of Success: A Prospective Study , 2012, Current Urology.

[16]  M. Goldstein,et al.  Varicocele as a risk factor for androgen deficiency and effect of repair , 2011, BJU international.

[17]  P. Stahl,et al.  Standardization and documentation of varicocele evaluation , 2011, Current opinion in urology.

[18]  M. Marconi,et al.  Color Doppler ultrasound imaging in varicoceles: is the venous diameter sufficient for predicting clinical and subclinical varicocele? , 2011, World Journal of Urology.

[19]  L. Lipshultz,et al.  Varicocele repair in patients with nonobstructive azoospermia: a meta-analysis. , 2010, The Journal of urology.

[20]  K. Glassberg,et al.  Testicular asymmetry and adolescent varicoceles managed expectantly. , 2010, Journal of Urology.

[21]  Elizabeth Noonan,et al.  World Health Organization reference values for human semen characteristics. , 2010, Human reproduction update.

[22]  G D Adamson,et al.  International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. , 2009, Fertility and sterility.

[23]  K. Glassberg,et al.  Peak retrograde flow: a novel predictor of persistent, progressive and new onset asymmetry in adolescent varicocele. , 2009, The Journal of urology.

[24]  A. Kadıoğlu,et al.  Treatment of palpable varicocele in infertile men: a meta-analysis to define the best technique. , 2008, Journal of andrology.

[25]  A. Al-Ansari,et al.  Varicocelectomy for male infertility: a comparative study of open, laparoscopic and microsurgical approaches. , 2008, The Journal of urology.

[26]  D. Coplen Relationship of Varicocele Grade and Testicular Hypotrophy to Semen Parameters in Adolescents , 2008 .

[27]  F. Pasqualotto,et al.  Reassessing the value of varicocelectomy as a treatment for male subfertility with a new meta-analysis. , 2007, Fertility and sterility.

[28]  A. Agarwal,et al.  Efficacy of varicocelectomy in improving semen parameters: new meta-analytical approach. , 2007, Urology.

[29]  H. Patel,et al.  Predictors of Success in Surgical Ligation of Painful Varicocele , 2007, Urologia Internationalis.

[30]  A. Shokeir,et al.  Comparison of outcomes of different varicocelectomy techniques: open inguinal, laparoscopic, and subinguinal microscopic varicocelectomy: a randomized clinical trial. , 2007, Urology.

[31]  Y. Ogawa,et al.  Testicular volume measurement: comparison of ultrasonography, orchidometry, and water displacement. , 2007, Urology.

[32]  A. Hussein The role of color Doppler ultrasound in prediction of the outcome of microsurgical subinguinal varicocelectomy. , 2006, The Journal of urology.

[33]  D. Acar,et al.  Adolescent varicocele repair: long-term results and comparison of surgical techniques according to optical magnification use in 100 cases at a single university hospital. , 2005, The Journal of urology.

[34]  A. Zitella,et al.  Inguinal versus subinguinal varicocele vein ligation using magnifying loupe under local anesthesia: which technique is preferable in clinical practice? , 2005, Urology.

[35]  Masami Watanabe,et al.  Minimal invasiveness and effectivity of subinguinal microscopic varicocelectomy: a comparative study with retroperitoneal high and laparoscopic approaches , 2005, International journal of urology : official journal of the Japanese Urological Association.

[36]  F. Ates,et al.  Evaluation of the role of varicocelectomy including external spermatic vein ligation in patients with scrotal pain , 2005, International journal of urology : official journal of the Japanese Urological Association.

[37]  E. Kass The adolescent varicocele: Treatment and outcome , 2002, Current urology reports.

[38]  O. Karatas,et al.  Clomiphene citrate versus varicocelectomy in treatment of subclinical varicocele: A prospective randomized study , 2001, International journal of urology : official journal of the Japanese Urological Association.

[39]  E. Kass,et al.  Varicocele in adolescence induces left and right testicular volume loss , 2001, BJU International.

[40]  P. Schlegel Is assisted reproduction the optimal treatment for varicocele-associated male infertility? A cost-effectiveness analysis. , 1997, Urology.

[41]  F. van der Veen,et al.  The value of palpation, varicoscreen contact thermography and colour Doppler ultrasound in the diagnosis of varicocele. , 1996, Human reproduction.

[42]  Masanori Yamamoto,et al.  Effect of varicocelectomy on sperm parameters and pregnancy rate in patients with subclinical varicocele: a randomized prospective controlled study. , 1996, The Journal of urology.

[43]  H. Deshmukh,et al.  Post-surgical recurrent varicocele: efficacy of internal spermatic venography and steel-coil embolization. , 1996, British journal of urology.

[44]  M. Goldstein,et al.  Intraoperative varicocele anatomy: a macroscopic and microscopic study. , 1992, The Journal of urology.

[45]  L. Dubin,et al.  Varicocele size and results of varicocelectomy in selected subfertile men with varicocele. , 1970, Fertility and sterility.

[46]  O. Ivanissevich Left varicocele due to reflux; experience with 4,470 operative cases in forty-two years. , 1960, The Journal of the International College of Surgeons.

[47]  A. Palomo Radical cure of varicocele by a new technique; preliminary report. , 1949, The Journal of urology.