Homonuclear broad-band-decoupled chemical shift imaging by singular value decomposition with optimization

The conventional viewpoint of localized NMR spectroscopy is to acquire spectral information through time-domain data, while leaving spatial information to phase encoding by incremental magnetic field gradients. A second viewpoint, much less frequently used, places the emphasis on the acquisition of spatially well-resolved images by conventional means, leaving the chemical shift segregation through phase encoding in the incremental t(1) period (in a 2-DNMR parlance). The feasibility and practicality of the second viewpoint are demonstrated by implementation of a modified version of the SLIM technique, which was originally designed for the first viewpoint, using simulated and real phantom data with optimization of the t(1)-encoding parameters.

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