Using Twin-Screw Melt Granulation to Co-Process Mannitol and Hydroxypropylcellulose (Klucel™)

[1]  A. Dhingra,et al.  Co-processed excipients: Recent advances and future perspective , 2022, Journal of Drug Delivery Science and Technology.

[2]  Ivana M. Cotabarren,et al.  Binder-free twin-screw melt granulation: an effective approach to manufacture high-dose API formulations. , 2021, International journal of pharmaceutics.

[3]  Seth P Forster,et al.  Continuous Melt Granulation for Taste-Masking of Ibuprofen , 2021, Pharmaceutics.

[4]  A. Bansal,et al.  Co-processing of small molecule excipients with polymers to improve functionality , 2021, Expert opinion on drug delivery.

[5]  Changquan Calvin Sun,et al.  How Does the Dissimilarity of Screw Geometry Impact Twin-screw Melt Granulation? , 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[6]  Tongzhou Liu,et al.  Mechanisms of twin screw melt granulation , 2020 .

[7]  Changquan Calvin Sun,et al.  Effect of Hydroxypropyl Cellulose Level on Twin-Screw Melt Granulation of Acetaminophen , 2020, AAPS PharmSciTech.

[8]  Tongzhou Liu,et al.  Twin-Screw Melt Granulation: Current Progress and Challenges. , 2020, International journal of pharmaceutics.

[9]  K. Wagner,et al.  Improvement of tabletability via twin-screw melt granulation: focus on binder distribution. , 2019, International journal of pharmaceutics.

[10]  Changquan Calvin Sun,et al.  Tableting performance of various mannitol and lactose grades assessed by compaction simulation and chemometrical analysis. , 2019, International journal of pharmaceutics.

[11]  Changquan Calvin Sun,et al.  Effect of screw profile and processing conditions on physical transformation and chemical degradation of gabapentin during twin‐screw melt granulation , 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[12]  C Vervaet,et al.  Downstream processing from melt granulation towards tablets: In‐depth analysis of a continuous twin‐screw melt granulation process using polymeric binders , 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[13]  J. Khinast,et al.  In‐line measurement of residence time distribution in melt extrusion via video analysis , 2018 .

[14]  Amol Batra,et al.  Investigating the Use of Polymeric Binders in Twin Screw Melt Granulation Process for Improving Compactibility of Drugs. , 2017, Journal of pharmaceutical sciences.

[15]  Chris Vervaet,et al.  Continuous melt granulation: Influence of process and formulation parameters upon granule and tablet properties. , 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[16]  T. De Beer,et al.  The use of rheology to elucidate the granulation mechanisms of a miscible and immiscible system during continuous twin-screw melt granulation. , 2016, International journal of pharmaceutics.

[17]  M. Repka,et al.  Formulation and development of pH-independent/dependent sustained release matrix tablets of ondansetron HCl by a continuous twin-screw melt granulation process. , 2015, International journal of pharmaceutics.

[18]  Changquan Calvin Sun,et al.  Validation and applications of an expedited tablet friability method. , 2015, International journal of pharmaceutics.

[19]  J. Rojas.  Excipient Design by Co-Processing for Direct Compression Applications , 2015 .

[20]  Bo Lang,et al.  Hot-melt extrusion – basic principles and pharmaceutical applications , 2014, Drug development and industrial pharmacy.

[21]  Eva Schornick,et al.  Why is mannitol becoming more and more popular as a pharmaceutical excipient in solid dosage forms? , 2014, Pharmaceutical development and technology.

[22]  Charles E. Martin,et al.  Twin Screw Extrusion for Pharmaceutical Processes , 2013 .

[23]  Vijay Kumar,et al.  Co-proccessed excipients with enhanced direct compression functionality for improved tableting performance , 2012, Drug development and industrial pharmacy.

[24]  Weiqin Tong,et al.  Application of melt granulation technology using twin-screw extruder in development of high-dose modified-release tablet formulation. , 2011, Journal of pharmaceutical sciences.

[25]  A. Serajuddin,et al.  Application of melt granulation technology to enhance tabletting properties of poorly compactible high-dose drugs. , 2011, Journal of pharmaceutical sciences.

[26]  Changquan Calvin Sun.  Decoding Powder Tabletability: Roles of Particle Adhesion and Plasticity , 2011 .

[27]  Michael J. Hounslow,et al.  Twin screw wet granulation: Granule properties , 2010 .

[28]  M. Al-Tabakha,et al.  Cellactose® a Co-processed Excipient: A Comparison Study , 2008 .

[29]  K. Picker-Freyer,et al.  Physical mechanical and tablet formation properties of hydroxypropylcellulose: In pure form and in mixtures , 2007, AAPS PharmSciTech.

[30]  S. Jacob,et al.  Novel co-processed excipients of mannitol and microcrystalline cellulose for preparing fast dissolving tablets of glipizide , 2007 .

[31]  Jean Paul Remon,et al.  Continuous granulation in the pharmaceutical industry , 2005 .

[32]  Arvind K. Bansal,et al.  Coprocessed excipients for solid dosage forms , 2004 .

[33]  P. Cassagnau,et al.  A New Approach for Modelling Residence Time Distribution in a Co-rotating Twin Screw Extruder , 2001, CHIMIA.

[34]  T Schaefer,et al.  Effects of interactions between powder particle size and binder viscosity on agglomerate growth mechanisms in a high shear mixer. , 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[35]  A. Royce,et al.  Alternative Granulation Technique: Melt Granulation , 1996 .

[36]  J. Newton,et al.  Determination of tablet strength by the diametral-compression test. , 1970, Journal of pharmaceutical sciences.