High Dosage Chlorpromazine Treatment in Chronic Schizophrenic Patients

1. Chlorpromazine treatment was carried out with 53 female patients, 43 of whom were chronic schizophrenics. The dosage was high, up to 3,000 mgs. daily and the treatment lengthy, from six to eight months. 2. Among the chronic schizophrenic, remission occurred in 20% and Social Remission in 37% of the cases. Length of illness and grades of deterioration bear an inverse relationship to improvement. 3. Both paranoid and simplex schizophrenic patients benefitted from the treatment. 4. No permanent liver damage occurred. A large percentage of the previously positive CCF tests improved during the treatment and this was paralleled by psychological improvement.