New Algorithmic and Software Tools for D-Optimal Design Computation in Nonlinear Regression

The aim of this paper is to present 1. A new theoretical result for a problem of long standing (Atkinson et al. 1968, Box 1968) in the Theory of Optimal Design in Nonlinear Regression: the determination of optimality conditions for designs made of replications of the minimal D-optimal designs points (Vila 1986). 2. A new easy-to-use powerful software for optimal design computation in nonlinear regression, following the D-optimality criterion and other allied criteria.