Biocatalytic Cascade for Synthesis of Sitagliptin Intermediate Employing Coupled Transaminase

[1]  Seon-Won Kim,et al.  Advanced Whole-cell Conversion for D-allulose Production Using an Engineered Corynebacterium glutamicum , 2022, Biotechnology and Bioprocess Engineering.

[2]  Hyunwoo Jeon,et al.  Synthesis of Sitagliptin Intermediate by a Multi-Enzymatic Cascade System Using Lipase and Transaminase With Benzylamine as an Amino Donor , 2021, Frontiers in Bioengineering and Biotechnology.

[3]  S. Yeom,et al.  Efficient Production of Phenyllactic Acid by Whole-cell Biocatalysis with Cofactor Regeneration System , 2021, Biotechnology and Bioprocess Engineering.

[4]  Hye-Jung Park,et al.  Promoter engineering‐mediated Tuning of esterase and transaminase expression for the chemoenzymatic synthesis of sitagliptin phosphate at the kilogram‐scale , 2021, Biotechnology and bioengineering.

[5]  P. Dawson,et al.  Recent Advances in Biocatalysis with Chemical Modification and Expanded Amino Acid Alphabet. , 2021, Chemical reviews.

[6]  Zhi-Qiang Liu,et al.  Creation of a robust and R-selective ω-amine transaminase for the asymmetric synthesis of sitagliptin intermediate on a kilogram scale. , 2020, Enzyme and microbial technology.

[7]  V. Wendisch,et al.  Development of a Corynebacterium glutamicum bio-factory for self-sufficient transaminase reactions , 2020 .

[8]  B. Hauer.  Embracing Nature’s Catalysts: A Viewpoint on the Future of Biocatalysis , 2020 .

[9]  Joonwon Kim,et al.  Production of 12-hydroxy dodecanoic acid methyl ester using a signal peptide sequence-optimized transporter AlkL and a novel monooxygenase. , 2019, Bioresource technology.

[10]  Hyunwoo Jeon,et al.  Kinetic Resolution of Racemic Amines to Enantiopure (S)-amines by a Biocatalytic Cascade Employing Amine Dehydrogenase and Alanine Dehydrogenase , 2019, Catalysts.

[11]  H. Schwab,et al.  A co-expression system to shift the equilibrium of transamination reactions toward the synthesis of enantiomerically pure amines , 2019, Molecular Catalysis.

[12]  Sihyong Sung,et al.  Deracemization of Racemic Amines to Enantiopure (R)‐ and (S)‐amines by Biocatalytic Cascade Employing ω‐Transaminase and Amine Dehydrogenase , 2019, ChemCatChem.

[13]  J. Shin,et al.  Activity Improvements of an Engineered ω-transaminase for Ketones Are Positively Correlated with Those for Cognate Amines , 2019, Biotechnology and Bioprocess Engineering.

[14]  Sihyong Sung,et al.  Enzymatic synthesis of sitagliptin intermediate using a novel ω-transaminase. , 2019, Enzyme and microbial technology.

[15]  Byung-Gee Kim,et al.  Parallel anti-sense two-step cascade for alcohol amination leading to ω-amino fatty acids and α,ω-diamines , 2018 .

[16]  M. Fraaije,et al.  Enzyme Fusions in Biocatalysis: Coupling Reactions by Pairing Enzymes , 2018, Chembiochem : a European journal of chemical biology.

[17]  Byung-Gee Kim,et al.  Characterization of ELP-fused ω-Transaminase and Its Application for the Biosynthesis of β-Amino Acid , 2018, Biotechnology and Bioprocess Engineering.

[18]  U. Bornscheuer,et al.  Isopropylamine as Amine Donor in Transaminase‐Catalyzed Reactions: Better Acceptance through Reaction and Enzyme Engineering , 2018, ChemCatChem.

[19]  A. Bommarius,et al.  Recent Advances in ω-Transaminase-Mediated Biocatalysis for the Enantioselective Synthesis of Chiral Amines , 2018, Catalysts.

[20]  Wolfgang Kroutil,et al.  Vicinal Diamines as Smart Cosubstrates in the Transaminase-Catalyzed Asymmetric Amination of Ketones , 2017 .

[21]  Per Berglund,et al.  Transaminase biocatalysis: optimization and application , 2017 .

[22]  William Lewis,et al.  A New Generation of Smart Amine Donors for Transaminase-Mediated Biotransformations. , 2016, Chemistry.

[23]  G. Sadowski,et al.  Thermodynamics of the alanine aminotransferase reaction , 2016 .

[24]  Z. Deng,et al.  Substrate screening of amino transaminase for the synthesis of a sitagliptin intermediate , 2016 .

[25]  Hyungdon Yun,et al.  Asymmetric synthesis of aromatic β‐amino acids using ω‐transaminase: Optimizing the lipase concentration to obtain thermodynamically unstable β‐keto acids , 2016, Biotechnology journal.

[26]  M. F. Villegas-Torres,et al.  Multi-step biocatalytic strategies for chiral amino alcohol synthesis. , 2015, Enzyme and microbial technology.

[27]  Nicholas J Turner,et al.  Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor that Displaces Equilibria and Enables High-Throughput Screening** , 2014, Angewandte Chemie.

[28]  Michele Forlin,et al.  Gene position more strongly influences cell-free protein expression from operons than T7 transcriptional promoter strength. , 2014, ACS synthetic biology.

[29]  Wolfgang Kroutil,et al.  Recent Developments of Cascade Reactions Involving ω‑Transaminases , 2014 .

[30]  R. Breinbauer,et al.  Investigation of one-enzyme systems in the ω-transaminase-catalyzed synthesis of chiral amines , 2013 .

[31]  Wei-Chiang Shen,et al.  Fusion protein linkers: property, design and functionality. , 2013, Advanced drug delivery reviews.

[32]  J. Shin,et al.  ω-Transaminase from Ochrobactrum anthropi Is Devoid of Substrate and Product Inhibitions , 2013, Applied and Environmental Microbiology.

[33]  Hyungdon Yun,et al.  ω-Transaminases for the Production of Optically Pure Amines and Unnatural Amino Acids , 2012 .

[34]  F. G. Mutti,et al.  Stereoselectivity of Four (R)‐Selective Transaminases for the Asymmetric Amination of Ketones , 2011 .

[35]  Aman A Desai,et al.  Sitagliptin manufacture: a compelling tale of green chemistry, process intensification, and industrial asymmetric catalysis. , 2011, Angewandte Chemie.

[36]  Per Berglund,et al.  Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration. , 2010, Chemical communications.

[37]  Paul N. Devine,et al.  Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture , 2010, Science.

[38]  W. Kroutil,et al.  Synthesis of Optically Active Amines Employing Recombinant ω‐Transaminases in E. coli Cells , 2010 .

[39]  Feng Xu,et al.  Highly efficient asymmetric synthesis of sitagliptin. , 2009, Journal of the American Chemical Society.

[40]  Karen Robins,et al.  Efficient Asymmetric Synthesis of Chiral Amines by Combining Transaminase and Pyruvate Decarboxylase , 2008, Chembiochem : a European journal of chemical biology.

[41]  C. Starbuck,et al.  Identification of Ammonium Chloride as an Effective Promoter of the Asymmetric Hydrogenation of a β-Enamine Amide , 2006 .

[42]  Edward J. J. Grabowski,et al.  First Generation Process for the Preparation of the DPP-IV Inhibitor Sitagliptin , 2005 .

[43]  N. Rivera.  Highly Efficient Synthesis of β‐Amino Acid Derivatives via Asymmetric Hydrogenation of Unprotected Enamines. , 2004 .

[44]  George Zhou,et al.  Mechanistic Evidence for an α-Oxoketene Pathway in the Formation of β-Ketoamides/Esters via Meldrum's Acid Adducts , 2004 .

[45]  Shane W. Krska,et al.  Highly efficient synthesis of beta-amino acid derivatives via asymmetric hydrogenation of unprotected enamines. , 2004, Journal of the American Chemical Society.

[46]  J. Shin,et al.  Exploring the active site of amine:pyruvate aminotransferase on the basis of the substrate structure-reactivity relationship: how the enzyme controls substrate specificity and stereoselectivity. , 2002, The Journal of organic chemistry.