论文信息 - Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors. - 字舞流文

Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors.

A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat P2X7 receptor and provides useful pharmacological tools for evaluation of the role of P2X7 in disease.

Martin Braddock | Mark Furber | Keith Bowers | Mark J. Robertson | M. Braddock | R. Weaver | R. Riley | A. Pimm | M. Robertson | L. Alcaraz | Michael Mortimore | Robert J. Riley | P. Webborn | Elizabeth Kinchin | D. Donald | Lilian Alcaraz | Peter J. H. Webborn | N. Roberts | Janice Bent | Armin Beyerbach | Moya Caffrey | David Cladingboel | John Collington | David K. Donald | Malbinder Fagura | Frank Ince | Celine Laurent | Mandy Lawson | Timothy Jon Luker | Austen Pimm | Nicola J. Roberts | Jill Theaker | Philip Thorne | Richard J. Weaver | Paul Willis | M. Mortimore | M. Lawson | F. Ince | T. Luker | E. Kinchin | M. Caffrey | D. Cladingboel | M. Furber | K. Bowers | A. Beyerbach | C. Laurent | J. Theaker | P. Thorne | M. Fagura | J. Collington | J. Bent | P. Willis | Jill Theaker