Premature delivery due to intrauterine Candida infection that caused neonatal congenital cutaneous candidiasis: A case report

Congenital cutaneous candidiasis is a very rare disease with less than 100 cases published in the medical literature. Neonates having this disease present with systemic skin lesions caused by intrauterine Candida infections. We present a case of threatened premature delivery due to Candida chorioamnionitis, which caused both maternal postpartum endometritis and neonatal congenital cutaneous candidiasis. A 34‐year‐old woman who was admitted for fetal membrane bulging at 20 weeks of gestation underwent McDonald cervical cerclage. We diagnosed threatened premature delivery due to intrauterine infection; therefore, we terminated the gestation by cesarean section at 24 weeks of gestation. Fungi‐like yeast was detected in infantile gastric juice. Histopathological findings of the placenta revealed that Candida albicans mycelium invaded the placenta, chorioamniotic membrane and umbilical cord.

[1]  G. Darmstadt,et al.  Congenital cutaneous candidiasis: clinical presentation, pathogenesis, and management guidelines. , 2000, Pediatrics.

[2]  B. Young,et al.  Intra amniotic candidiasis. Case report and meta-analysis of 54 cases , 1999, Journal of perinatal medicine.

[3]  R. Frydman,et al.  Infection maternofœtale disséminée à Candida albicans et grande prématurité , 1997 .

[4]  R. Frydman,et al.  [Maternofetal disseminated candidiasis and high-grade prematurity]. , 1997, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[5]  A. Endo,et al.  Congenital systemic candidiasis. , 1995, The Pediatric infectious disease journal.

[6]  R. Haziroğlu,et al.  In vitro infection of human fetal membranes with Candida species. , 1994, Gynecologic and obstetric investigation.

[7]  P. Moerman,et al.  Intra-uterine Candida infection: a report of four infected fetusses from two mothers. , 1991, European journal of obstetrics, gynecology, and reproductive biology.

[8]  S. Hayashi,et al.  Infection of Human Fetal Membranes in vitro with Candida albicans: Die Infektion menschlicher Eihaute in vitro mit Candida albicans , 1989, Mycoses.

[9]  R. Goldblum,et al.  A case of intrauterine pulmonary candidiasis. , 1985, Pediatric infectious disease.

[10]  A. Schirar,et al.  Congenital mycosis (Candida albicans). , 1974, Biology of the neonate.

[11]  K. Aterman,et al.  Intra-uterine infection by Candida. , 1968, American journal of diseases of children.

[12]  R. Rhatigan.  Congenital cutaneous candidiasis. , 1968, American journal of diseases of children.

[13]  A. Dvorak,et al.  Congenital systemic candidiasis. Report of a case. , 1966, The New England journal of medicine.

[14]  W. Blanc.  Pathways of fetal and early neonatal infection. Viral placentitis, bacterial and fungal chorioamnionitis. , 1961, The Journal of pediatrics.

[15]  H. Clark,et al.  Congenital cutaneous candidiasis in a premature infant. , 1960, A.M.A. journal of diseases of children.

[16]  K. Benirschke,et al.  Candida albicans infection of the amniotic sac. , 1958, American journal of obstetrics and gynecology.

[17]  H. Sturde,et al.  [Additional studies on the practical use of the chorioallantois test for yeast differentiation]. , 1956, Archiv fur klinische und experimentelle Dermatologie.