Two cases of retroperitoneal hematoma caused by combination of anticoagulant therapy and 5-fluorouracil.

We reported two cases of retroperitoneal hematoma in patients who received a combination of anticoagulant therapy and 5-fluorouracil (5-FU). We should be aware of the possible interaction of this combination therapy and monitor prothrombin time (PT) prolongation. CT is useful for evaluation of the disease.

[1]  I. Choo,et al.  Transcatheter embolization of the marginal artery of drummond as treatment for life-threatening retroperitoneal hemorrhage complicating heparin therapy , 1994, CardioVascular and Interventional Radiology.

[2]  J. Riancho,et al.  The Clinical Spectrum of Retroperitoneal Hematoma in Anticoagulated Patients , 2003, Medicine.

[3]  S. Borzak,et al.  How safely and for how long can warfarin therapy be withheld in prosthetic heart valve patients hospitalized with a major hemorrhage? , 2001, Chest.

[4]  J. Berlin,et al.  Warfarin—5‐FU Interaction — A Consecutive Case Series , 1999, Pharmacotherapy.

[5]  Michael C. Brown An Adverse Interaction between Warfarin and 5-Fluorouracil: A Case Report and Review of the Literature , 1999, Chemotherapy.

[6]  Michael C. Brown Multisite Mucous Membrane Bleeding Due to a Possible Interaction Between Warfarin and 5‐Fluorouracil , 1997, Pharmacotherapy.

[7]  M. Israel,et al.  Possible Drug Interaction between Warfarin and Combination of Levamisole and Fluorouracil , 1994, The Annals of pharmacotherapy.

[8]  L. Woldenberg,et al.  Percutaneous decompression for femoral neuropathy secondary to heparin-induced retroperitoneal hematoma: case report and review of the literature. , 1991, The American surgeon.

[9]  R. Chlebowski,et al.  Clinical and Pharmacokinetic Effects of Combined Warfarin and 5-Fluorouracil in Advanced Colon Cancer , 1982 .

[10]  H. Neiman,et al.  Diagnosis of retroperitoneal hemorrhage by serial computed tomography. , 1979, Journal of computer assisted tomography.

[11]  Y. Heilbronn,et al.  CT scan of retroperitoneal hematoma with neuropathy. , 1979, Surgical neurology.