The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders

[1]  C. Rapinesi,et al.  Neuroinflammation in bipolar disorders , 2015 .

[2]  P. Vajkoczy,et al.  Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells , 2015, International journal of cancer.

[3]  E. Kong,et al.  The poly(I:C)-induced maternal immune activation model in preclinical neuropsychiatric drug discovery. , 2015, Pharmacology & therapeutics.

[4]  M. Koch,et al.  Prenatal LPS-exposure – a neurodevelopmental rat model of schizophrenia – differentially affects cognitive functions, myelination and parvalbumin expression in male and female offspring , 2015, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[5]  D. Carroll,et al.  Negative life events and symptoms of depression and anxiety: stress causation and/or stress generation , 2015, Anxiety, stress, and coping.

[6]  S. Maier,et al.  Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome , 2015, The Journal of Neuroscience.

[7]  A. Carvalho,et al.  Ketamine ameliorates depressive-like behaviors and immune alterations in adult rats following maternal deprivation , 2015, Neuroscience Letters.

[8]  R. Leak,et al.  Microglial and macrophage polarization—new prospects for brain repair , 2015, Nature Reviews Neurology.

[9]  S. Najjar,et al.  Neuroinflammation and white matter pathology in schizophrenia: systematic review , 2015, Schizophrenia Research.

[10]  Minocycline protects against oxidative damage and alters energy metabolism parameters in the brain of rats subjected to chronic mild stress , 2015, Metabolic Brain Disease.

[11]  Y. Nakagawa,et al.  Role of Microglial M1/M2 Polarization in Relapse and Remission of Psychiatric Disorders and Diseases , 2014, Pharmaceuticals.

[12]  GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders , 2014, Journal of Neuroinflammation.

[13]  D. Finn,et al.  Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression , 2014, Brain, Behavior, and Immunity.

[14]  G. Turecki,et al.  Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides , 2014, Brain, Behavior, and Immunity.

[15]  D. Hermann,et al.  Insights from interferon-α-related depression for the pathogenesis of depression associated with inflammation , 2014, Brain, Behavior, and Immunity.

[16]  L. Quevedo,et al.  Immune dysfunction in bipolar disorder and suicide risk: is there an association between peripheral corticotropin-releasing hormone and interleukin-1β? , 2014, Bipolar disorders.

[17]  A. Weeren,et al.  The risk for behavioural deficits is determined by the maternal immune response to prenatal immune challenge in a neurodevelopmental model , 2014, Brain, Behavior, and Immunity.

[18]  C. Beasley,et al.  Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder. , 2014, Journal of psychiatry & neuroscience : JPN.

[19]  Alcino J. Silva,et al.  Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells , 2014, Stem cell reports.

[20]  H. Abelaira,et al.  Epigenetic and epistatic interactions between serotonin transporter and brain-derived neurotrophic factor genetic polymorphism: Insights in depression , 2014, Neuroscience.

[21]  T. Deak,et al.  The impact of the P2X7 receptor antagonist A-804598 on neuroimmune and behavioral consequences of stress , 2014, Behavioural pharmacology.

[22]  G. Rosoklija,et al.  Microglia of Prefrontal White Matter in Suicide , 2014, Journal of neuropathology and experimental neurology.

[23]  X. Zhang,et al.  Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway , 2014, Journal of Neuroinflammation.

[24]  R. McIntyre,et al.  Inflamed moods: A review of the interactions between inflammation and mood disorders , 2014, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[25]  V. Guajardo,et al.  Relationship of cortisol levels and genetic polymorphisms to antidepressant response to placebo and fluoxetine in patients with major depressive disorder: a prospective study , 2014, BMC Psychiatry.

[26]  H. Abelaira,et al.  MAPK signaling correlates with the antidepressant effects of ketamine. , 2014, Journal of psychiatric research.

[27]  Zili You,et al.  Maternal sleep deprivation inhibits hippocampal neurogenesis associated with inflammatory response in young offspring rats , 2014, Neurobiology of Disease.

[28]  W. Nolen,et al.  Neuroinflammation in bipolar disorder – A [11C]-(R)-PK11195 positron emission tomography study , 2014, Brain, Behavior, and Immunity.

[29]  R. Leak,et al.  Neurobiology of microglial action in CNS injuries: Receptor-mediated signaling mechanisms and functional roles , 2014, Progress in Neurobiology.

[30]  O. Andreassen,et al.  The plasma levels of various cytokines are increased during ongoing depression and are reduced to normal levels after recovery , 2014, Psychoneuroendocrinology.

[31]  R. McIntyre,et al.  Tryptophan breakdown is increased in euthymic overweight individuals with bipolar disorder: a preliminary report , 2014, Bipolar disorders.

[32]  K. Tracey,et al.  Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review , 2014, Expert review of clinical immunology.

[33]  J. Price,et al.  Neuropathological and neuromorphometric abnormalities in bipolar disorder: View from the medial prefrontal cortical network , 2014, Neuroscience & Biobehavioral Reviews.

[34]  H. Abelaira,et al.  The role of mTOR in depression and antidepressant responses. , 2014, Life sciences.

[35]  K. Hashimoto,et al.  Effects of Brilliant Blue G on Serum Tumor Necrosis Factor-α Levels and Depression-like Behavior in Mice after Lipopolysaccharide Administration , 2014, Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology.

[36]  A. Depino,et al.  Altered Peripheral and Central Inflammatory Responses in a Mouse Model of Autism , 2014, Autism research : official journal of the International Society for Autism Research.

[37]  J. Attia,et al.  Autoantibodies and depression Evidence for a causal link? , 2014, Neuroscience & Biobehavioral Reviews.

[38]  Francesco Sforazzini,et al.  Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior , 2014, Nature Neuroscience.

[39]  Alan S. Brown,et al.  The Cytokine Model of Schizophrenia: Emerging Therapeutic Strategies , 2014, Biological Psychiatry.

[40]  S. Maier,et al.  Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus , 2014, Psychoneuroendocrinology.

[41]  A. Verkhratsky,et al.  The glial perspective of autism spectrum disorders , 2014, Neuroscience & Biobehavioral Reviews.

[42]  H. Anisman,et al.  Living with the unexplained: coping, distress, and depression among women with chronic fatigue syndrome and/or fibromyalgia compared to an autoimmune disorder , 2014, Anxiety, stress, and coping.

[43]  A. Sawa,et al.  Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application , 2014, Translational Psychiatry.

[44]  S. Dedeurwaerdere,et al.  Hypolocomotive behaviour associated with increased microglia in a prenatal immune activation model with relevance to schizophrenia , 2014, Behavioural Brain Research.

[45]  T. van der Poll,et al.  Host innate immune responses to sepsis , 2013, Virulence.

[46]  J. Sandkühler,et al.  Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity , 2013, Nature Reviews Neuroscience.

[47]  P. Rinwa,et al.  Quercetin suppress microglial neuroinflammatory response and induce antidepressent-like effect in olfactory bulbectomized rats , 2013, Neuroscience.

[48]  D. Diamond,et al.  Influence of Post-Traumatic Stress Disorder on Neuroinflammation and Cell Proliferation in a Rat Model of Traumatic Brain Injury , 2013, PloS one.

[49]  A. Pfennig,et al.  Disturbed sleep in bipolar disorder is related to an elevation of IL-6 in peripheral monocytes. , 2013, Medical hypotheses.

[50]  C. Gama,et al.  Evidences for a progressive microglial activation and increase in iNOS expression in rats submitted to a neurodevelopmental model of schizophrenia: Reversal by clozapine , 2013, Schizophrenia Research.

[51]  Antônio Lúcio Teixeira,et al.  Altered intracellular signaling cascades in peripheral blood mononuclear cells from BD patients. , 2013, Journal of psychiatric research.

[52]  H. Abelaira,et al.  Ketamine and imipramine in the nucleus accumbens regulate histone deacetylation induced by maternal deprivation and are critical for associated behaviors , 2013, Behavioural Brain Research.

[53]  E. Audinat,et al.  Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation , 2013, Cell Death and Differentiation.

[54]  M. Nilsson,et al.  Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function , 2013, Current drug targets.

[55]  S. Hodgkinson,et al.  Immune dysregulation and autoimmunity in bipolar disorder: Synthesis of the evidence and its clinical application , 2013, The Australian and New Zealand journal of psychiatry.

[56]  R. Dantzer,et al.  NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice , 2013, Neuropsychopharmacology.

[57]  Andrew H. Miller Conceptual Confluence: The Kynurenine Pathway as a Common Target for Ketamine and the Convergence of the Inflammation and Glutamate Hypotheses of Depression , 2013, Neuropsychopharmacology.

[58]  D. Amaral,et al.  Myeloid dendritic cells frequencies are increased in children with autism spectrum disorder and associated with amygdala volume and repetitive behaviors , 2013, Brain, Behavior, and Immunity.

[59]  J. R. Pauly,et al.  Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: The importance of microglia phenotype , 2013, Neurobiology of Disease.

[60]  G. Martino,et al.  Lentiviral-mediated administration of IL-25 in the CNS induces alternative activation of microglia , 2012, Gene Therapy.

[61]  S. Asadi,et al.  Focal brain inflammation and autism , 2013, Journal of Neuroinflammation.

[62]  U. Meyer Developmental neuroinflammation and schizophrenia , 2013, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[63]  H. Abelaira,et al.  Imipramine reverses alterations in cytokines and BDNF levels induced by maternal deprivation in adult rats , 2013, Behavioural Brain Research.

[64]  M. Nilsson,et al.  Chronic stress-induced disruption of the astrocyte network is driven by structural atrophy and not loss of astrocytes , 2013, Acta Neuropathologica.

[65]  H. Steinbusch,et al.  Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia , 2013, Brain, Behavior, and Immunity.

[66]  B. Conti,et al.  Corticosteroids limit microglial activation occurring during acute stress , 2013, Neuroscience.

[67]  R. Rupprecht,et al.  Send Orders of Reprints at Reprints@benthamscience.net Targeting Glia Cells: Novel Perspectives for the Treatment of Neuro- Psychiatric Diseases , 2022 .

[68]  V. Perry,et al.  Review: Activation patterns of microglia and their identification in the human brain , 2013, Neuropathology and applied neurobiology.

[69]  L. Garcia-Segura,et al.  Prenatal stress increases the expression of proinflammatory cytokines and exacerbates the inflammatory response to LPS in the hippocampal formation of adult male mice , 2013, Brain, Behavior, and Immunity.

[70]  K. Hashimoto,et al.  Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration , 2013, Pharmacology Biochemistry and Behavior.

[71]  A. Teixeira,et al.  Pathophysiology of bacterial infection of the central nervous system and its putative role in the pathogenesis of behavioral changes. , 2013, Revista brasileira de psiquiatria.

[72]  F. Kapczinski,et al.  Is bipolar disorder an inflammatory condition? The relevance of microglial activation , 2013, Current opinion in psychiatry.

[73]  F. Kapczinski,et al.  The P 2 X 7 purinergic receptor as a molecular target in bipolar disorder , 2013 .

[74]  H. Abelaira,et al.  Animal models as tools to study the pathophysiology of depression. , 2013, Revista brasileira de psiquiatria.

[75]  Yasuomi Ouchi,et al.  Microglial activation in young adults with autism spectrum disorder. , 2013, JAMA psychiatry.

[76]  O. Devinsky,et al.  Neuroinflammation and psychiatric illness , 2013, Journal of Neuroinflammation.

[77]  Y. Sekino,et al.  L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation , 2012, Journal of Neuroinflammation.

[78]  D. Kupfer,et al.  Can bipolar disorder be viewed as a multi-system inflammatory disease? , 2012, Journal of affective disorders.

[79]  S. Kennedy,et al.  Novel therapeutic targets in depression: Minocycline as a candidate treatment , 2012, Behavioural Brain Research.

[80]  L. Pont-Lezica,et al.  The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes , 2012, Journal of leukocyte biology.

[81]  H. Abelaira,et al.  Increased prevalence of mood disorders and suicidal ideation in type 2 diabetic patients , 2012, Acta Diabetologica.

[82]  M. Santello,et al.  TNFα in synaptic function: switching gears , 2012, Trends in Neurosciences.

[83]  J. Palermo-neto,et al.  Hypoactivity of the central dopaminergic system and autistic‐like behavior induced by a single early prenatal exposure to lipopolysaccharide , 2012, Journal of neuroscience research.

[84]  F. Walker,et al.  Evidence that microglia mediate the neurobiological effects of chronic psychological stress on the medial prefrontal cortex. , 2012, Cerebral cortex.

[85]  Ian Abramson,et al.  Abnormal microglial–neuronal spatial organization in the dorsolateral prefrontal cortex in autism , 2012, Brain Research.

[86]  L. Garcia-Segura,et al.  Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice , 2012, Journal of Neuroinflammation.

[87]  J. Camden,et al.  P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation , 2012, Molecular Neurobiology.

[88]  Brian A Williams,et al.  Microglia in the Cerebral Cortex in Autism , 2012, Journal of Autism and Developmental Disorders.

[89]  M. Cairns,et al.  A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia , 2012, Brain, Behavior, and Immunity.

[90]  Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats , 2012, Metabolic Brain Disease.

[91]  S. Maier,et al.  Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses , 2012, Brain, Behavior, and Immunity.

[92]  Yuko Fujita,et al.  Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline , 2012, Pharmacology Biochemistry and Behavior.

[93]  James C. Cronk,et al.  Wild type microglia arrest pathology in a mouse model of Rett syndrome , 2012, Nature.

[94]  Christine T. Ekdahl,et al.  Microglial Activation – Tuning and Pruning Adult Neurogenesis , 2011, Front. Pharmacol..

[95]  Andrew H. Miller,et al.  Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior , 2012, Neuropsychopharmacology.

[96]  Wei Li,et al.  Role of microglia in CNS inflammation , 2011, FEBS letters.

[97]  Exposure to Prenatal Infection and Risk of Schizophrenia , 2011, Front. Psychiatry.

[98]  M. Schroeter,et al.  Glial pathology is modified by age in mood disorders--a systematic meta-analysis of serum S100B in vivo studies. , 2011, Journal of affective disorders.

[99]  C. Glass,et al.  Microglial cell origin and phenotypes in health and disease , 2011, Nature Reviews Immunology.

[100]  B. Kirkpatrick,et al.  Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects , 2011, Biological Psychiatry.

[101]  M. Nilsson,et al.  Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β , 2011, Neurobiology of Disease.

[102]  L. Grinberg,et al.  Morphometric post-mortem studies in bipolar disorder: possible association with oxidative stress and apoptosis. , 2011, The international journal of neuropsychopharmacology.

[103]  M. Won,et al.  Microglia in the normally aged hippocampus , 2011, Laboratory animal research.

[104]  Elaine C. Campbell,et al.  Aberrant NF-KappaB Expression in Autism Spectrum Condition: A Mechanism for Neuroinflammation , 2011, Front. Psychiatry.

[105]  Sung‐Hwa Yoon,et al.  Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation , 2011, Neuropharmacology.

[106]  S. Sugama,et al.  Cold stress induced morphological microglial activation and increased IL-1β expression in astroglial cells in rat brain , 2011, Journal of Neuroimmunology.

[107]  Sung‐Hwa Yoon,et al.  Fluoxetine prevents LPS-induced degeneration of nigral dopaminergic neurons by inhibiting microglia-mediated oxidative stress , 2010, Brain Research.

[108]  Elliot T. Berkman,et al.  Inflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward , 2010, Biological Psychiatry.

[109]  Z. Chi,et al.  The role of p38 MAPK in valproic acid induced microglia apoptosis , 2010, Neuroscience Letters.

[110]  Izumi Maezawa,et al.  Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated Release of Glutamate , 2010, The Journal of Neuroscience.

[111]  R. Roesler,et al.  Neurochemical and behavioural effects of acute and chronic memantine administration in rats: Further support for NMDA as a new pharmacological target for the treatment of depression? , 2010, Brain Research Bulletin.

[112]  S. Rapoport,et al.  Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients , 2010, Molecular Psychiatry.

[113]  C. Colton,et al.  Assessing activation states in microglia. , 2010, CNS & neurological disorders drug targets.

[114]  P. Sawchenko,et al.  Dual Roles for Perivascular Macrophages in Immune-to-Brain Signaling , 2010, Neuron.

[115]  B. Gómez-González,et al.  Prenatal stress alters microglial development and distribution in postnatal rat brain , 2010, Acta Neuropathologica.

[116]  M. Kubera,et al.  Concomitant administration of fluoxetine and amantadine modulates the activity of peritoneal macrophages of rats subjected to a forced swimming test , 2009, Pharmacological reports : PR.

[117]  B. Leonard,et al.  Imbalance between Pro- and Anti-inflammatory Cytokines, and between Th1 and Th2 Cytokines in Depressed Patients: The Effect of Electroacupuncture or Fluoxetine Treatment , 2009, Pharmacopsychiatry.

[118]  H. Critchley,et al.  Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity , 2009, Biological Psychiatry.

[119]  B. Bogerts,et al.  A New Pathophysiological Aspect of S100B in Schizophrenia: Potential Regulation of S100B by Its Scavenger Soluble RAGE , 2009, Biological Psychiatry.

[120]  Takahiro A. Kato,et al.  Cytokines and schizophrenia: Microglia hypothesis of schizophrenia , 2009, Psychiatry and clinical neurosciences.

[121]  Charles L. Raison,et al.  Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression , 2009, Biological Psychiatry.

[122]  R. Dantzer,et al.  Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice , 2009, Molecular Psychiatry.

[123]  G. Réus,et al.  Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats , 2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[124]  V. Perry,et al.  Microglial physiology: unique stimuli, specialized responses. , 2009, Annual review of immunology.

[125]  G. Réus,et al.  Chronic administration of ketamine elicits antidepressant-like effects in rats without affecting hippocampal brain-derived neurotrophic factor protein levels. , 2008, Basic & clinical pharmacology & toxicology.

[126]  R. Boellaard,et al.  Microglia Activation in Recent-Onset Schizophrenia: A Quantitative (R)-[11C]PK11195 Positron Emission Tomography Study , 2008, Biological Psychiatry.

[127]  Henry A. Nasrallah,et al.  Schizophrenia, “Just the Facts” What we know in 2008. 2. Epidemiology and etiology , 2008, Schizophrenia Research.

[128]  Zubin Bhagwagar,et al.  Inflammation, Glutamate, and Glia in Depression: A Literature Review , 2008, CNS Spectrums.

[129]  D. Geschwind,et al.  Advances in autism genetics: on the threshold of a new neurobiology , 2008, Nature Reviews Genetics.

[130]  Ta-Liang Chen,et al.  Ketamine inhibits tumor necrosis factor-alpha and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation. , 2008, Toxicology and applied pharmacology.

[131]  G. Réus,et al.  Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus , 2008, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[132]  B. Bogerts,et al.  Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide. , 2008, Journal of psychiatric research.

[133]  R. Dantzer,et al.  From inflammation to sickness and depression: when the immune system subjugates the brain , 2008, Nature Reviews Neuroscience.

[134]  A. Serretti,et al.  Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia , 2008, European Archives of Psychiatry and Clinical Neuroscience.

[135]  P. Gean,et al.  Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity , 2007, Neuroscience.

[136]  T. Kosaka,et al.  Spatial arrangement of microglia in the mouse hippocampus: A stereological study in comparison with astrocytes , 2007, Glia.

[137]  S. Barger,et al.  Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation , 2007, Journal of neurochemistry.

[138]  B. Conti,et al.  Stress induced morphological microglial activation in the rodent brain: Involvement of interleukin-18 , 2007, Neuroscience.

[139]  E. Ling,et al.  Microglial activation and its implications in the brain diseases. , 2007, Current medicinal chemistry.

[140]  J. Ferguson,et al.  An Open-label, Flexible-Dose Study of Memantine in Major Depressive Disorder , 2007, Clinical neuropharmacology.

[141]  P. Scully,et al.  Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy. , 2007, Journal of psychiatric research.

[142]  R. Yolken,et al.  Toxoplasma gondii as a Risk Factor for Early-Onset Schizophrenia: Analysis of Filter Paper Blood Samples Obtained at Birth , 2007, Biological Psychiatry.

[143]  P. Gean,et al.  Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes , 2006, Molecular Psychiatry.

[144]  Takeshi Yamada,et al.  Short communication Correlation between plasma levels of glutamate, alanine and serine with severity of depression , 2006 .

[145]  Paul J Carlson,et al.  A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. , 2006, Archives of general psychiatry.

[146]  Steffen Jung,et al.  Control of microglial neurotoxicity by the fractalkine receptor , 2006, Nature Neuroscience.

[147]  Alan S. Brown,et al.  Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia. , 2006, The American journal of psychiatry.

[148]  P. Falkai,et al.  Increased serum S100B in elderly, chronic schizophrenic patients: Negative correlation with deficit symptoms , 2005, Schizophrenia Research.

[149]  F. Helmchen,et al.  Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo , 2005, Science.

[150]  D. Chuang,et al.  Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia. , 2005, Brain research. Molecular brain research.

[151]  M. Wichers,et al.  Cytokines and major depression , 2005, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[152]  J. Price,et al.  Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes , 2004, Biological Psychiatry.

[153]  H. Kornhuber,et al.  Increased serum glutamate in depressed patients , 2004, Archiv für Psychiatrie und Nervenkrankheiten.

[154]  E. Susser,et al.  Serologic evidence for prenatal influenza in the etiology of schizophrenia , 2003, Schizophrenia Research.

[155]  C. Tato,et al.  Host-Pathogen Interactions: Subversion and Utilization of the NF-κB Pathway during Infection , 2002, Infection and Immunity.

[156]  C. Tato,et al.  Host-pathogen interactions: subversion and utilization of the NF-kappa B pathway during infection. , 2002, Infection and immunity.

[157]  S. J. Lee,et al.  Identification of antibodies to heat shock proteins 90 kDa and 70 kDa in patients with schizophrenia , 2001, Schizophrenia Research.

[158]  S. Barger,et al.  Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function , 2001, Journal of neurochemistry.

[159]  Jon W. Johnson,et al.  Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures* , 2000, The Journal of Biological Chemistry.

[160]  John H Krystal,et al.  Antidepressant effects of ketamine in depressed patients , 2000, Biological Psychiatry.

[161]  L. Garey,et al.  Increase in HLA‐DR Immunoreactive Microglia in Frontal and Temporal Cortex of Chronic Schizophrenics , 2000, Journal of neuropathology and experimental neurology.

[162]  P. Falkai,et al.  Evidence for activation of microglia in patients with psychiatric illnesses , 1999, Neuroscience Letters.

[163]  Georg W. Kreutzberg,et al.  Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function , 1999, Brain Research Reviews.

[164]  M. Sakanaka,et al.  Glucocorticoid‐ and mineralocorticoid receptors in microglial cells: The two receptors mediate differential effects of corticosteroids , 1997, Glia.

[165]  A. F. Schinder,et al.  Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity , 1996, The Journal of Neuroscience.

[166]  Y. Imai,et al.  A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. , 1996, Biochemical and biophysical research communications.

[167]  E. Major,et al.  Human microglia convert l-tryptophan into the neurotoxin quinolinic acid. , 1992, The Biochemical journal.

[168]  K. Frei,et al.  Macrophage‐induced cytotoxicity of N‐methyl‐D‐aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines , 1992, European journal of immunology.

[169]  M. Egan,et al.  Schizophrenia, just the facts What do we know, how well do we know it? , 1988, Schizophrenia Research.

[170]  M. Sherman,et al.  A Preliminary Report , 1953 .