Loss of cardiac mitochondrial complex I persulfidation impairs NAD+ homeostasis in aging

[1]  Sofia-Iris Bibli,et al.  Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation. , 2023, Redox biology.

[2]  A. Papapetropoulos,et al.  CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway , 2023, Frontiers in Pharmacology.

[3]  J. Pfeilschifter,et al.  Hydrogen Sulfide Modulates Endothelial–Mesenchymal Transition in Heart Failure , 2022, Circulation research.

[4]  N. Nagahara,et al.  Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure , 2022, Circulation research.

[5]  C. Antoniades,et al.  MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity , 2022, The Journal of experimental medicine.

[6]  Dongming Xing,et al.  Targeting NAD+: is it a common strategy to delay heart aging? , 2022, Cell death discovery.

[7]  A. Papapetropoulos,et al.  Physiological roles of hydrogen sulfide in mammalian cells, tissues and organs. , 2022, Physiological reviews.

[8]  G. Kroemer,et al.  NAD+ Metabolism in Cardiac Health, Aging, and Disease. , 2021, Circulation.

[9]  L. Sazanov,et al.  The assembly, regulation and function of the mitochondrial respiratory chain , 2021, Nature Reviews Molecular Cell Biology.

[10]  Sofia-Iris Bibli,et al.  Oxidative post translational modifications: a focus on cysteine S-sulfhydration and the regulation of endothelial fitness. , 2021, Antioxidants & redox signaling.

[11]  Murugesan V. S. Rajaram,et al.  Aging influences the cardiac macrophage phenotype and function during steady state and during inflammation , 2021, Aging cell.

[12]  G. Kroemer,et al.  Nicotinamide for the treatment of heart failure with preserved ejection fraction , 2021, Science Translational Medicine.

[13]  S. Knapp,et al.  Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function. , 2020, Circulation.

[14]  Dean P. Jones,et al.  Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. , 2020, Antioxidants & redox signaling.

[15]  N. Nagahara,et al.  Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase. , 2020, Biochemical pharmacology.

[16]  Kate S. Carroll,et al.  Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration. , 2020, Cell metabolism.

[17]  Manish Kumar,et al.  Mapping the protein phosphorylation sites in human mitochondrial complex I (NADH: Ubiquinone oxidoreductase): A bioinformatics study with implications for brain aging and neurodegeneration , 2019, Journal of Chemical Neuroanatomy.

[18]  R. Brandes,et al.  Cystathionine &ggr; Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis , 2019, Circulation.

[19]  Arif Yurdagul,et al.  Cystathionine &ggr;-Lyase Modulates Flow-Dependent Vascular Remodeling , 2018, Arteriosclerosis, thrombosis, and vascular biology.

[20]  C. Leeuwenburgh,et al.  Mitochondrial quality control mechanisms as molecular targets in cardiac ageing , 2018, Nature Reviews Cardiology.

[21]  L. Guarente,et al.  Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging , 2018, Cell.

[22]  J. Locasale,et al.  Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model. , 2017, JCI insight.

[23]  R. Foo,et al.  A Simplified, Langendorff-Free Method for Concomitant Isolation of Viable Cardiac Myocytes and Nonmyocytes From the Adult Mouse Heart. , 2016, Circulation research.

[24]  D. Seals,et al.  Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice , 2016, Aging cell.

[25]  M. Mericskay Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential. , 2016, Archives of cardiovascular diseases.

[26]  D. Granger,et al.  Reperfusion injury and reactive oxygen species: The evolution of a concept☆ , 2015, Redox biology.

[27]  Hongzhu Li,et al.  Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis , 2013, Circulation.

[28]  N. Nagahara,et al.  Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria , 2013, Scientific Reports.

[29]  A. Papapetropoulos,et al.  Intramitochondrial hydrogen sulfide production by 3‐mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  Hussein Mansour,et al.  Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats , 2011, PloS one.

[31]  M. Huynen,et al.  NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I , 2011, FEBS letters.

[32]  S. Jha,et al.  Genetic and Pharmacologic Hydrogen Sulfide Therapy Attenuates Ischemia-Induced Heart Failure in Mice , 2010, Circulation.

[33]  S. Snyder,et al.  H2S Signals Through Protein S-Sulfhydration , 2009, Science Signaling.

[34]  P. Rabinovitch,et al.  Cardiac aging in mice and humans: the role of mitochondrial oxidative stress. , 2009, Trends in cardiovascular medicine.

[35]  M. MacCoss,et al.  Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging , 2009, Circulation.

[36]  S. Snyder,et al.  H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase , 2008, Science.

[37]  S. Imai,et al.  Poly(ADP-ribose) Polymerase-1-dependent Cardiac Myocyte Cell Death during Heart Failure Is Mediated by NAD+ Depletion and Reduced Sir2α Deacetylase Activity* , 2005, Journal of Biological Chemistry.

[38]  M. Talan,et al.  Oxygen consumption in adult and aged C57BL/6J mice during acute treadmill exercise of different intensity , 1996, Experimental Gerontology.