Association of the glutathione S-transferase M1 homozygous null genotype with susceptibility to Sjögren's syndrome in Japanese individuals.

OBJECTIVE To investigate the role of polymorphisms of the glutathione S-transferase M1 (GSTM1) and GSTT1 genes in determining susceptibility to Sjögren's syndrome (SS) and autoantibody production. METHODS Polymorphisms of the GSTM1 and GSTT1 genes in 106 Japanese patients with primary SS and in 143 healthy controls were analyzed by polymerase chain reaction. RESULTS Frequency of the GSTM1 homozygous null genotype was significantly increased in SS patients compared with controls (57.5% versus 44.1%; P = 0.035). Moreover, a significantly greater frequency of SSA antibodies was found among SS patients with the GSTM1 null genotype than among those with the GSTM1 non-null genotype (P = 0.0013). Frequency of the GSTT1 polymorphism was not different between SS patients and controls. CONCLUSION The GSTM1 homozygous null genotype could be a genetic factor that determines susceptibility to SS and may be involved in SSA antibody production.

[1]  H. Saji,et al.  Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjögren's syndrome. , 1997, Arthritis and rheumatism.

[2]  M. Relling,et al.  Higher Frequency of Glutathione S-Transferase Deletions in Black Children With Acute Lymphoblastic Leukemia , 1997 .

[3]  W. Ollier,et al.  Association of homozygosity for glutathione-S-transferase GSTM1 null alleles with the Ro+/La- autoantibody profile in patients with systemic lupus erythematosus. , 1996, Arthritis and rheumatism.

[4]  D. Bell,et al.  Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma. , 1996, Carcinogenesis.

[5]  C. Smith,et al.  Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual. , 1996, Carcinogenesis.

[6]  C. Bologna,et al.  Sicca syndrome associated with hepatitis C virus infection. , 1996, Arthritis and rheumatism.

[7]  K. Noda,et al.  Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population. , 1995, Carcinogenesis.

[8]  A. Fryer,et al.  Susceptibility to ulcerative colitis and Crohn's disease: interactions between glutathione S-transferase GSTM1 and GSTT1 genotypes. , 1995, Clinica chimica acta; international journal of clinical chemistry.

[9]  D. Isenberg,et al.  Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European Community. , 1993, Arthritis and rheumatism.

[10]  M. Hochberg,et al.  Two Ro (SS-A) autoantibody responses in systemic lupus erythematosus. Correlation of HLA-DR/DQ specificities with quantitative expression of Ro (SS-A) autoantibody. , 1988, Arthritis and rheumatism.

[11]  F. Arnett,et al.  Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjögren's syndrome. , 1986, Arthritis and rheumatism.

[12]  M. Hochberg,et al.  Sjögren's syndrome. Influence of multiple HLA-D region alloantigens on clinical and serologic expression. , 1984, Arthritis and rheumatism.

[13]  H. Nakamura,et al.  Redox regulation of cellular activation. , 1997, Annual review of immunology.

[14]  R. Morgenstern,et al.  Enzymology of microsomal glutathione S-transferase. , 1994, Advances in pharmacology.