The trans-ancestral genomic architecture of glycemic traits

Tanya M. Teslovich | Peter K. Joshi | May E. Montasser | Nicholette D. Palmer | Sara M. Willems | Cassandra N. Spracklen | Dermot F. Reilly | M. Jarvelin | E. Zeggini | G. Abecasis | E. Boerwinkle | N. Grarup | C. Steves | J. O’Connell | Z. Kutalik | M. Boehnke | P. Ridker | D. Chasman | P. Munroe | M. Caulfield | T. Frayling | N. Timpson | V. Gudnason | T. Kawaguchi | G. Marenne | A. Zonderman | T. Ahluwalia | K. Bønnelykke | S. Kardia | K. Small | G. Willemsen | N. Sattar | A. Metspalu | P. Kaleebu | E. Ingelsson | Michael H. Preuss | K. Mohlke | L. Bonnycastle | H. Stringham | J. Saramies | V. Lyssenko | R. Rueedi | J. Jonas | R. Rauramaa | B. Cade | I. Rudan | D. Boomsma | E. D. de Geus | J. Long | L. Bielak | P. Peyser | T. Sofer | M. Horikoshi | A. Mahajan | J. Hottenga | M. Beekman | S. Gustafsson | H. Grallert | I. Prokopenko | Xiuqing Guo | C. Sabanayagam | C. Marzi | C. Schurmann | C. Herder | Q. Cai | A. Gloyn | J. Kooner | T. Wilsgaard | N. Robertson | N. Amin | C. Hayward | P. Joshi | M. Kaakinen | I. Kolčić | O. Polašek | V. Vitart | F. Cucca | G. Eiriksdottir | L. Launer | H. Vestergaard | S. Heckbert | R. Noordam | F. Hartwig | Jin-Fang Chai | J. Luan | I. Nolte | S. Padmanabhan | F. Takeuchi | P. J. van der Most | H. Warren | W. Wen | L. Yanek | Jinghua Zhao | M. Canouil | Q. Duan | B. Gigante | C. Khor | J. Kuusisto | C. Langenberg | M. Loh | T. Louie | L. Raffel | Kathryn Roll | J. Chambers | K. Leander | A. Oldehinkel | P. van der Harst | L. Wagenknecht | R. V. van Dam | D. Mook-Kanamori | S. Sanna | R. Strawbridge | L. Yengo | A. Wood | B. Sennblad | S. Keinanen-Kiukaanniemi | T. Saaristo | D. Baldassarre | E. Tremoli | A. Demirkan | M. Kleber | M. Goodarzi | A. Hicks | M. Kumari | D. Kuh | P. Pramstaller | F. Matsuda | J. Jukema | P. Gordon-Larsen | C. Fuchsberger | A. Linneberg | B. Thuesen | T. Sparsø | M. Nelis | S. Trompet | G. Delgado | D. van Heemst | N. Verweij | Aliki-Eleni Farmaki | L. Lange | R. Li-Gao | Kevin Sandow | L. Southam | A. Gjesing | N. Lee | Y. Tabara | T. Kuulasmaa | H. Koistinen | H. Moreno-Macías | M. Nakatochi | Emil V. R. Appel | L. Rasmussen-Torvik | Chien-Hsiun Chen | T. Zemunik | G. Pistis | Damia Noce | L. Raffield | A. Claringbould | Mattias Frånberg | T. Hansen | M. Ikram | Y. Hai | R. Jensen | G. Dedoussis | Arushi Varshney | Heming Wang | E. B. van den Akker | S. Mooijaart | S. Grimsgaard | R. Lemaitre | Sohee Han | M. Zafarmand | Mark Walker | A. Huerta-Chagoya | Man-jia Li | Ji Chen | M. Y. Hwang | Yujie Wang | L. Avilés-Santa | J. Vangipurapu | S. Ichihara | P. Magnusson | D. Lawlor | J. Engmann | K. Willems van Dijk | H. D. de Haan | Jani Heikkinen | P. Timmers | S. Fatumo | A. van Hylckama Vlieg | Liang Sun | Jinxiu Shi | S. Du | Xiaoran Chai | K. Kentistou | Thibaud S. Boutin | Chelsea K Raulerson | Sanghoon Moon | K. Setoh | M. Igase | Annette Peters | Jennifer A. Brody | N. Kato | Peitao Wu | I. Stewart | K. Chitrala | Peter J. van der Most | Y. Heianza | Jingyi Tan | Yujie Wang | Z. Arzumanyan | S. Rich | M. D. Anasanti | Shaofeng Huo | Tian Xie | Kelvin Lam | Fernando Rivideneira | T. Tusié | Jianjun Liu | J. Yao | Huaixing Li | M. Kivimaki | Katharina E. Schraut | Harry Campbell | Nan Wang | Li Chang | Jerry L. Nadler | M. Yokota | Linda S. Adair | D. Porteous | L. Lind | M. E. Jørgensen | Franco Giulianini | I. Barroso | Willa A. Hsueh | T. Spector | E. Tai | LJ Corbin | James F. Wilson | Don Bowden | A. Tönjes | Peter Kovacs | Corrinda Black | Chaolong Wang | Kristi Läll | R. Kaplan | Pankow S. James | Rita R. Kalyani | Bernardo L. Horta | Weihua Zhang | Reedik Mägi | Yasumasa Ohyagi | Honglan Li | A. Goel | P. Slagboom | S. Kardia | Symen Ligthart | M. Sandhu | F. Collins | P. James | W. C. Johnson | Markku Laakso | Peter E. H. Schwarz | Denis Rybin | Dennis Raven | Alice Stanton | Ruth J. F. Loos | Jerome I. Rotter | Matthias Blüher | Ying Wu | Robert A. Scott | A. R. Wickremasinghe | Toru Nabika | Albert V Smith | Hugh Watkins | Oluf Pedersen | Bong-Jo Kim | Anders Hamsten | I. Njølstad | Bernhard O. Böhm | Ching-Yu Cheng | Michael Stumvoll | Ken K Ong | Ken K. Ong | Matti Uusitupa | Wieland Kiess | Elizabeth Selvin | Richa Saxena | P. Froguel | Wei Zhao | Blair H. Smith | T. I. Sørensen | A. Campbell | M. McCarthy | Cecilia M. Lindgren | A. Uitterlinden | Kari E. North | C. Langefeld | Andrew P. Morris | Ching-Ti Liu | S. Redline | J. Tuomilehto | Ping An | R. Bergman | R. M. Watanabe | I. Kooner | Lawrence J. Beilin | H. Bisgaard | N. Burtt | James B. Meigs | Matthew J Neville | L. Groop | Carlos Lorenzo | G. Mingrone | Claudia P. Cabrera | Annette Schürmann | Peter S. Sever | Jose C. Florez | Abbas Dehghan | Sven Bergmann | Alice V Stanton | Xueling Sim | Tien Y. Wong | Harold Snieder | Diane M. Becker | J. Lindström | Wei Huang | Jianjun Liu | B. Psaty | Stephan J L Bakker | Rebecca R. Rohde | Albert V. Smith | Jana V. van Vliet-Ostaptchouk | Jianjun Liu | Erwin P. Bottinger | Jing He | Lu Qi | Young Jin Kim | Stefan R. Bornstein | W. Zheng | P. Vollenweider | Matthew Neville | Abhishek Nag | Johannes Waage | Nick J. Wareham | Jill M. Norris | Thomas A. Buchanan | Kari North | Y. I. Chen | Laura J. Scott | Y. X. Wang | Arne Astrup | A. V. Smith | José E Dupuis | Wen-bin Wei | L. Ferrucci | Colin N. A. Palmer | Cornelia M. Van Duijn | Mandy Vogel | Xiaoshuai Zhang | Kei Hang Katie Chan | Audrey Y. Chu | Jaeyoung Hong | Winfried März | Anne T Ndungu | Sarah C. Nelson | Debashree Ray | Carol A. Wang | Chien-Hsiun Chen | Brian H. Chen | Yen-Feng Chiu | Javier Gayán | Jung Ho Gong | Tao Huang | Shuiqing Lai | Marie Lauzon | Jun Liu | Massimo Mangino | Kathleen A. Ryan | Chaolong Wang | Andrew Wong | Alain G Bertoni | Yi-Cheng Chang | Shufa Du | Yutang Gao | C. A. Hartman | Chang-Hsun Hsieh | Sahoko Ichihara | Fouad R. Kandeel | Tomohiro Katsuya | Honglan Li | Shih-Yi Lin | Tatsuaki Matsubara | G. N. Nadkarni | Qibin Qi | Alexander Reiner | Kent D. Taylor | Michael Y. Tsai | Tao Wang | Carlos Aguilar-Salinas | M. Alarcón-Riquelme | Adolfo Correa | H. J. de Silva | Sölve Elmståhl | Michele K. Evans | E. Ferrannini | Paul W. Franks | Antje Körner | Timo A. Lakka | Xu Lin | Simin Liu | Trevor A Mori | Craig E Pennell | Michael A. Province | F. R. Rosendaal | Neil Schneiderman | X. Shu | Tamar Sofer | Tanja G. M. Vrijkotte | Jer-Yuarn wu | Anny H. Xiang | Aaron Leong | Stephen C. J. Parker | Eleanor Wheeler | Hugoline G. Erik Peter J. Eco J. C. Rob M. Diana Astrid Ko de Haan van den Akker van der Most de Ge | Ko van Willems van Dijk | Craig E. Pennell | Tao Wang | A. Smith | Stephan J. L. Bakker | M. Laakso | Lawrence Beilin | C. N. Palmer | Kari E North | P. Sever | A. Hamsten | H. Snieder | C. Hartman | Adolfo Correa | Carol A Wang | Yujie Wang | Alain Bertoni | B. L. Horta | F. Rosendaal | Kent D. Taylor | S. Bakker | W. Johnson | Alain G. Bertoni | C. Pennell | Carol A. Wang | Yutang Gao | Alexander P. Reiner | H. D. de Silva | Huaixing Li | Ya X. Wang | Nick J Wareham | Jer-Yuarn Wu | Alicia Huerta-Chagoya | Alexander P Reiner | K. Taylor | K. North | A. Astrup | K. Chitrala | M. Province | Y. Ohyagi | C. Aguilar-Salinas | Yujie Wang | Chaolong Wang | Honglan Li | Audrey Y Chu | R. Mägi | Timo A Lakka | J. Meigs | Ruifang Li-Gao | Qing Duan | Marit E Jørgensen | Trevor A. Mori

[1]  M. McCarthy,et al.  Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine , 2019, Endocrine reviews.

[2]  Gad Getz,et al.  Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis , 2018, PLoS medicine.

[3]  Nicola J. Rinaldi,et al.  Genetic effects on gene expression across human tissues , 2017, Nature.

[4]  Christian Gieger,et al.  Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis , 2017, PLoS Medicine.

[5]  K. Rawlik,et al.  An atlas of genetic associations in UK Biobank , 2017, Nature Genetics.

[6]  Tanya M. Teslovich,et al.  An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans , 2017, Diabetes.

[7]  Neda Binesh,et al.  Fuzzy clustering in community detection based on nonnegative matrix factorization with two novel evaluation criteria , 2017, Appl. Soft Comput..

[8]  Roby Joehanes,et al.  Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies , 2017, Genome Biology.

[9]  A. Hofman,et al.  Identification of context-dependent expression quantitative trait loci in whole blood , 2016, Nature Genetics.

[10]  William J. Astle,et al.  Allelic Landscape of Human Blood Cell Trait Variation and Links , 2016 .

[11]  May E. Montasser,et al.  Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci , 2016, Diabetes.

[12]  Matti Pirinen,et al.  FINEMAP: efficient variable selection using summary data from genome-wide association studies , 2015, bioRxiv.

[13]  Christian Gieger,et al.  Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation , 2015, PLoS genetics.

[14]  J. Hirschhorn,et al.  Biological interpretation of genome-wide association studies using predicted gene functions , 2015, Nature Communications.

[15]  Toshiko Tanaka,et al.  Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis , 2014, Nature Communications.

[16]  Inês Barroso,et al.  Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity , 2014, Diabetes.

[17]  Zoltán Kutalik,et al.  Quality control and conduct of genome-wide association meta-analyses , 2014, Nature Protocols.

[18]  M. Daly,et al.  LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.

[19]  M. Peters,et al.  Systematic identification of trans eQTLs as putative drivers of known disease associations , 2013, Nature Genetics.

[20]  Kenny Q. Ye,et al.  An integrated map of genetic variation from 1,092 human genomes , 2012, Nature.

[21]  Tanya M. Teslovich,et al.  The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits , 2012, PLoS genetics.

[22]  Claude Bouchard,et al.  A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance , 2012, Nature Genetics.

[23]  Manolis Kellis,et al.  ChromHMM: automating chromatin-state discovery and characterization , 2012, Nature Methods.

[24]  A. Morris,et al.  Transethnic Meta-Analysis of Genomewide Association Studies , 2011, Genetic epidemiology.

[25]  Ahsan Huda,et al.  Faculty Opinions recommendation of Mapping and analysis of chromatin state dynamics in nine human cell types. , 2011 .

[26]  J. Rotter,et al.  Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance. , 2011, American journal of physiology. Endocrinology and metabolism.

[27]  G. Abecasis,et al.  MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes , 2010, Genetic epidemiology.

[28]  T. Mikkelsen,et al.  Comparative Epigenomic Analysis of Murine and Human Adipogenesis , 2010, Cell.

[29]  J. Danesh,et al.  Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies , 2010, The Lancet.

[30]  Hong-Wen Deng,et al.  Analyses and Comparison of Imputation-Based Association Methods , 2010, PloS one.

[31]  Christian Gieger,et al.  New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk , 2010, Nature Genetics.

[32]  Katsuhiko Kuwa,et al.  Approved IFCC recommendation on reporting results for blood glucose (abbreviated). , 2005, Clinical chemistry.

[33]  K. Roeder,et al.  Genomic Control for Association Studies , 1999, Biometrics.

[34]  Salvador Zubirán Instituto Nacional de Ciencias Medicas y Nutricion , 2016 .

[35]  A. Franklin,et al.  University of Texas Health Science Center at Houston. , 1983, Cutis.