Neuronal correlates of subjective sensory experience

When a near-threshold stimulus is presented, a sensory percept may or may not be produced. The unpredictable outcome of such perceptual judgment is believed to be determined by the activity of neurons in early sensory cortex. We analyzed the responses of neurons in primary somatosensory cortex, recorded while monkeys judged the presence or absence of threshold stimuli. We found that these responses did not covary with the monkeys' perceptual reports. In contrast, the activity of frontal lobe neurons did covary with trial-by-trial judgments. Further control and microstimulation experiments indicated that frontal lobe neurons are closely related to the monkeys' subjective experiences during sensory detection.

[1]  A. Stuart,et al.  Non-Parametric Statistics for the Behavioral Sciences. , 1957 .

[2]  D. M. Green,et al.  Signal detection theory and psychophysics , 1966 .

[3]  J. Hyvärinen,et al.  Cortical neuronal mechanisms in flutter-vibration studied in unanesthetized monkeys. Neuronal periodicity and frequency discrimination. , 1969, Journal of neurophysiology.

[4]  F. A. Seiler,et al.  Numerical Recipes in C: The Art of Scientific Computing , 1989 .

[5]  William H. Press,et al.  The Art of Scientific Computing Second Edition , 1998 .

[6]  D. Collett,et al.  Modeling Binary Data. , 1993 .

[7]  Ehud Zohary,et al.  Correlated neuronal discharge rate and its implications for psychophysical performance , 1994, Nature.

[8]  N. Logothetis,et al.  Activity changes in early visual cortex reflect monkeys' percepts during binocular rivalry , 1996, Nature.

[9]  K. H. Britten,et al.  A relationship between behavioral choice and the visual responses of neurons in macaque MT , 1996, Visual Neuroscience.

[10]  R. Romo,et al.  Somatosensory discrimination based on cortical microstimulation , 1998, Nature.

[11]  R. Romo,et al.  Neuronal correlates of parametric working memory in the prefrontal cortex , 1999, Nature.

[12]  M. Shadlen,et al.  Neural correlates of a decision in the dorsolateral prefrontal cortex of the macaque , 1999, Nature Neuroscience.

[13]  D. Steiner,et al.  Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia , 1999, Nature Neuroscience.

[14]  N. Logothetis,et al.  Multistable phenomena: changing views in perception , 1999, Trends in Cognitive Sciences.

[15]  R. Romo,et al.  Sensing without Touching Psychophysical Performance Based on Cortical Microstimulation , 2000, Neuron.

[16]  R. Romo,et al.  Neuronal correlates of sensory discrimination in the somatosensory cortex. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[17]  R. Romo,et al.  Periodicity and Firing Rate As Candidate Neural Codes for the Frequency of Vibrotactile Stimuli , 2000, The Journal of Neuroscience.

[18]  M Corbetta,et al.  Multiple neural correlates of detection in the human brain. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[19]  R. Desimone,et al.  Modulation of Oscillatory Neuronal Synchronization by Selective Visual Attention , 2001, Science.

[20]  E. Miller,et al.  An integrative theory of prefrontal cortex function. , 2001, Annual review of neuroscience.

[21]  J. Tanji.  Sequential organization of multiple movements: involvement of cortical motor areas. , 2001, Annual review of neuroscience.

[22]  W. Bair,et al.  Correlated Firing in Macaque Visual Area MT: Time Scales and Relationship to Behavior , 2001, The Journal of Neuroscience.

[23]  G. Rizzolatti,et al.  The Cortical Motor System , 2001, Neuron.

[24]  Jeffrey D. Schall,et al.  Neural basis of deciding, choosing and acting , 2001, Nature Reviews Neuroscience.

[25]  W. Singer,et al.  Rapid feature selective neuronal synchronization through correlated latency shifting , 2001, Nature Neuroscience.

[26]  R. Romo,et al.  Temporal Evolution of a Decision-Making Process in Medial Premotor Cortex , 2002, Neuron.

[27]  R. Romo,et al.  Neuronal correlates of decision-making in secondary somatosensory cortex , 2002, Nature Neuroscience.

[28]  R. Romo,et al.  Correlated Neuronal Discharges that Increase Coding Efficiency during Perceptual Discrimination , 2003, Neuron.

[29]  W. Press,et al.  Numerical Recipes in C++: The Art of Scientific Computing (2nd edn)1 Numerical Recipes Example Book (C++) (2nd edn)2 Numerical Recipes Multi-Language Code CD ROM with LINUX or UNIX Single-Screen License Revised Version3 , 2003 .

[30]  David J. Heeger,et al.  Neuronal correlates of perception in early visual cortex , 2003, Nature Neuroscience.

[31]  Jeffrey D. Schall,et al.  Relationship of presaccadic activity in frontal eye field and supplementary eye field to saccade initiation in macaque: Poisson spike train analysis , 2004, Experimental Brain Research.

[32]  R. Romo,et al.  Neuronal Correlates of a Perceptual Decision in Ventral Premotor Cortex , 2004, Neuron.

[33]  J. Kalaska,et al.  Neural Correlates of Reaching Decisions in Dorsal Premotor Cortex: Specification of Multiple Direction Choices and Final Selection of Action , 2005, Neuron.

[34]  M. Kenward,et al.  An Introduction to the Bootstrap , 2007 .

[35]  R. K. Simpson.  Nature Neuroscience , 2022 .