A graphical vector autoregressive modelling approach to the analysis of electronic diary data

BackgroundIn recent years, electronic diaries are increasingly used in medical research and practice to investigate patients' processes and fluctuations in symptoms over time. To model dynamic dependence structures and feedback mechanisms between symptom-relevant variables, a multivariate time series method has to be applied.MethodsWe propose to analyse the temporal interrelationships among the variables by a structural modelling approach based on graphical vector autoregressive (VAR) models. We give a comprehensive description of the underlying concepts and explain how the dependence structure can be recovered from electronic diary data by a search over suitable constrained (graphical) VAR models.ResultsThe graphical VAR approach is applied to the electronic diary data of 35 obese patients with and without binge eating disorder (BED). The dynamic relationships for the two subgroups between eating behaviour, depression, anxiety and eating control are visualized in two path diagrams. Results show that the two subgroups of obese patients with and without BED are distinguishable by the temporal patterns which influence their respective eating behaviours.ConclusionThe use of the graphical VAR approach for the analysis of electronic diary data leads to a deeper insight into patient's dynamics and dependence structures. An increasing use of this modelling approach could lead to a better understanding of complex psychological and physiological mechanisms in different areas of medical care and research.

[1]  G. Schwarz.  Estimating the Dimension of a Model , 1978 .

[2]  Quang Phuc Duong,et al.  ON THE CHOICE OF THE ORDER OF AUTOREGRESSIVE MODELS: A RANKING AND SELECTION APPROACH , 1984 .

[3]  Helmut Lütkepohl,et al.  Introduction to multiple time series analysis , 1991 .

[4]  Ian T. Jolliffe,et al.  Introduction to Multiple Time Series Analysis , 1993 .

[5]  J. Rabe-Jabłońska,et al.  [Affective disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association -- diagnostic and statistical manual of mental disorders]. , 1993, Psychiatria polska.

[6]  D. Edwards.  Introduction to graphical modelling , 1995 .

[7]  R. Dahlhaus.  Graphical interaction models for multivariate time series1 , 2000 .

[8]  Wolfgang Tschacher,et al.  Temporal interaction of process variables in psychotherapy , 2000 .

[9]  S. Shiffman,et al.  Binge antecedents in obese women with and without binge eating disorder. , 2000, Journal of consulting and clinical psychology.

[10]  Binge eating and binge eating disorder , 2000 .

[11]  C. Granger.  Investigating causal relations by econometric models and cross-spectral methods , 1969 .

[12]  A. Stone,et al.  Does momentary assessment detect binge eating in overweight women that is denied at interview , 2001 .

[13]  M. de Zwaan.  Binge eating disorder and obesity , 2001, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[14]  Ursula Gather,et al.  Graphical models for multivariate time series from intensive care monitoring , 2002, Statistics in medicine.

[15]  M. Eichler.  Granger causality and path diagrams for multivariate time series , 2007 .

[16]  Hans-Bernd Bludau,et al.  Use of Electronic Diaries within Treatment of Obesity and Binge Eating Disorder: First Experiences , 2002, Mobile Computing in Medicine.

[17]  Paul J. Pilon,et al.  Interaction between deterministic trend and autoregressive process , 2003 .

[18]  Rainer Goebel,et al.  Investigating directed cortical interactions in time-resolved fMRI data using vector autoregressive modeling and Granger causality mapping. , 2003, Magnetic resonance imaging.

[19]  Peter Green,et al.  Highly Structured Stochastic Systems , 2003 .

[20]  R. Striegel-Moore,et al.  Epidemiology of binge eating disorder. , 2003, The International journal of eating disorders.

[21]  R. Hu.  Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) , 2003 .

[22]  A. Stunkard,et al.  Binge eating disorder: disorder or marker? , 2003, The International journal of eating disorders.

[23]  W. Agras,et al.  The clinical significance of binge eating disorder. , 2003, The International journal of eating disorders.

[24]  Ingela Wiklund,et al.  Symptom recording in a randomised clinical trial: paper diaries vs. electronic or telephone data capture. , 2004, Controlled clinical trials.

[25]  David A. Williams,et al.  Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia. , 2005, Arthritis and rheumatism.

[26]  R. Dahlhaus,et al.  Using Interaction Graphs for Analysing the Therapy Process , 2005, Psychotherapy and Psychosomatics.

[27]  Michael Eichler,et al.  A graphical approach for evaluating effective connectivity in neural systems , 2005, Philosophical Transactions of the Royal Society B: Biological Sciences.

[28]  Denise E Wilfley,et al.  A comparison of quality of life in obese individuals with and without binge eating disorder. , 2005, The International journal of eating disorders.

[29]  David A. Williams,et al.  Characterization and consequences of pain variability in individuals with fibromyalgia. , 2005, Arthritis and rheumatism.

[30]  Safety and efficacy of an extended-regimen oral contraception utilizing low-dose ethinyl estradiol. , 2006, Contraception.

[31]  Jens Timmer,et al.  Handbook of Time Series Analysis , 2006 .

[32]  Michael Eichler,et al.  Graphical Modeling of Dynamic Relationships in Multivariate Time Series , 2006 .

[33]  J. Bensing,et al.  Electronic Momentary Assessment in Chronic Pain I: Psychological Pain Responses as Predictors of Pain Intensity , 2006, The Clinical journal of pain.

[34]  Lutz Kilian,et al.  NEW INTRODUCTION TO MULTIPLE TIME SERIES ANALYSIS, by Helmut Lütkepohl, Springer, 2005 , 2006, Econometric Theory.

[35]  A course of treatment of binge eating disorder: a time series approach , 2006 .

[36]  G Molenberghs,et al.  Random-effects models for multivariate repeated measures , 2007, Statistical methods in medical research.

[37]  David Weller,et al.  Are electronic diaries useful for symptoms research? A systematic review. , 2007, Journal of psychosomatic research.

[38]  B. Wild,et al.  Treatment Outcome in People with Subthreshold Compared with Full‐Syndrome Binge Eating Disorder , 2007, Obesity.

[39]  B. Tuschen-Caffier,et al.  Maintenance of binge eating through negative mood: a naturalistic comparison of binge eating disorder and bulimia nervosa. , 2007, The International journal of eating disorders.

[40]  Helmut Ltkepohl,et al.  New Introduction to Multiple Time Series Analysis , 2007 .

[41]  A. Stone,et al.  Using instrumented paper diaries to document self-monitoring patterns in weight loss. , 2008, Contemporary clinical trials.

[42]  C. Schade-Brittinger,et al.  The ANTOP study: focal psychodynamic psychotherapy, cognitive-behavioural therapy, and treatment-as-usual in outpatients with anorexia nervosa - a randomized controlled trial , 2009, Trials.

[43]  David Weller,et al.  Functional Somatic Symptoms and Psychological States: An Electronic Diary Study , 2009, Psychosomatic medicine.

[44]  Wesley K. Thompson,et al.  A stimulus-locked vector autoregressive model for slow event-related fMRI designs , 2009, NeuroImage.

[45]  R. Lipton,et al.  Early follow-up data from seizure diaries can be used to predict subsequent seizures in same cohort by borrowing strength across participants , 2009, Epilepsy & Behavior.

[46]  J. Bensing,et al.  Compliance with momentary pain measurement using electronic diaries: A systematic review , 2009, European journal of pain.

[47]  Jennifer N Stinson,et al.  Improving the assessment of pediatric chronic pain: harnessing the potential of electronic diaries. , 2009, Pain research & management.

[48]  G. Hajak,et al.  A 2-week efficacy and safety study of gaboxadol and zolpidem using electronic diaries in primary insomnia outpatients. , 2009, Sleep medicine.

[49]  H. Williams,et al.  The Use of Electronic Diaries in Dermatology Research , 2009, Dermatology.

[50]  J. Johnston,et al.  ADHD and anger contexts: electronic diary mood reports from mothers and children. , 2009, Journal of pediatric psychology.

[51]  Fabian Ramseyer,et al.  Modeling psychotherapy process by time-series panel analysis (TSPA) , 2009, Psychotherapy research : journal of the Society for Psychotherapy Research.

[52]  M. Eichler.  Graphical modelling of dynamic relationships in multivariate time series , 2022 .