A virtual-based task to assess place avoidance in humans

Spatial memory can be assessed by virtual reality-based tasks, some of them similar to those previously used in rodents. In this study a virtual place avoidance task was developed based on a rodent labyrinth to evaluate human spatial memory. The task required subjects to avoid in a virtual room a prohibited zone defined solely by distal cues, while they collected rewards. The size of the to-be-avoided area was used as an independent variable as well as the gender of the participants. Subjects displayed an adequate performance after a single 5-min trial, entering the prohibited area on very few occasions. Our results showed that the size of the prohibited zone can be used to adapt task difficulty to different populations. Moreover, males were faster than females. They collected more rewards and spent less time in the prohibited area. Data collected supports the spatial component of the task and the validity of this procedure for spatial memory assessment in human beings.

[1]  G. Iaria,et al.  Mental imagery skills and topographical orientation in humans: A correlation study , 2008, Behavioural Brain Research.

[2]  Debbie M. Kelly,et al.  Spatial navigation: Spatial learning in real and virtual environments , 2006 .

[3]  Bradley R Sturz,et al.  Encoding of variability of landmark-based spatial information , 2010, Psychological research.

[4]  M. Wesierska,et al.  Inactivating one hippocampus impairs avoidance of a stable room-defined place during dissociation of arena cues from room cues by rotation of the arena , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[5]  A. Fenton,et al.  Functional inactivation of dorsal hippocampus impairs active place avoidance in rats , 2000, Neuroscience Letters.

[6]  A. Fenton,et al.  Beyond Memory, Navigation, and Inhibition: Behavioral Evidence for Hippocampus-Dependent Cognitive Coordination in the Rat , 2005, The Journal of Neuroscience.

[7]  Jan Bures,et al.  New spatial cognition tests for mice: Passive place avoidance on stable and active place avoidance on rotating arenas , 2001, Brain Research Bulletin.

[8]  Leah H. Somerville,et al.  A time of change: Behavioral and neural correlates of adolescent sensitivity to appetitive and aversive environmental cues , 2010, Brain and Cognition.

[9]  Cong Huang,et al.  Gender differences in the neural correlates of response inhibition during a stop signal task , 2006, NeuroImage.

[10]  G. Iaria,et al.  Walking in the Corsi test: Which type of memory do you need? , 2008, Neuroscience Letters.

[11]  Adam N Mamelak,et al.  Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task , 2002, Behavioural Brain Research.

[12]  Jan Bures,et al.  Rat spatial memory tasks adapted for humans: Characterization in subjects with intact brain and subjects with medial temporal lobe lesions , 2002 .

[13]  A. Fenton,et al.  Transient sex differences in the between-sessions but not in the within-session memory underlying an active place avoidance task in weanling rats. , 2001, Behavioral neuroscience.

[14]  John A. King,et al.  Human hippocampus and viewpoint dependence in spatial memory , 2002, Hippocampus.

[15]  N. Burgess,et al.  Geometric determinants of human spatial memory , 2004, Cognition.

[16]  Vince D. Calhoun,et al.  Anomalous neural circuit function in schizophrenia during a virtual Morris water task , 2010, NeuroImage.

[17]  José Manuel Cimadevilla,et al.  A new virtual task to evaluate human place learning , 2008, Behavioural Brain Research.

[18]  Albert Rizzo,et al.  Is Learning and Memory Different in a Virtual Environment? , 2007, The Clinical neuropsychologist.

[19]  B. Sturz,et al.  Reorienting when cues conflict: A role for information content in spatial learning? , 2010, Behavioural Processes.

[20]  J. G. Bremner,et al.  The development of relational landmark use in six- to twelve-month-old infants in a spatial orientation task. , 2000, Child development.

[21]  A. Fenton,et al.  Passive and active place avoidance as a tool of spatial memory research in rats , 2000, Journal of Neuroscience Methods.

[22]  A. Fenton,et al.  Continuous place avoidance task reveals differences in spatial navigation in male and female rats , 2000, Behavioural Brain Research.

[23]  Jan Bureš,et al.  Allothetic orientation and sequential ordering of places is impaired in early stages of Alzheimer's disease: corresponding results in real space tests and computer tests , 2005, Behavioural Brain Research.

[24]  R. Astur,et al.  Sex differences and correlations in a virtual Morris water task, a virtual radial arm maze, and mental rotation , 2004, Behavioural Brain Research.

[25]  K. Jezek,et al.  Hippocampus-dependent retrieval and hippocampus-independent extinction of place avoidance navigation, and stress-induced out-of-context activation of a memory revealed by reversible lesion experiments in rats. , 2002, Physiological research.

[26]  Jan Bures,et al.  Neurophysiology of Spatial Cognition. , 2000, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[27]  J Bures,et al.  Both here and there: simultaneous expression of autonomous spatial memories in rats. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[28]  J. Bureš,et al.  Spatial navigation deficit in amnestic mild cognitive impairment , 2007, Proceedings of the National Academy of Sciences.

[29]  Jose M Cimadevilla,et al.  Virtual reality tasks disclose spatial memory alterations in fibromyalgia. , 2009, Rheumatology.

[30]  W. Scoville,et al.  LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS , 1957, Journal of neurology, neurosurgery, and psychiatry.

[31]  R. Sutherland,et al.  A characterization of performance by men and women in a virtual Morris water task: A large and reliable sex difference , 1998, Behavioural Brain Research.

[32]  Lorin J. Elias,et al.  Are sex differences in navigation caused by sexually dimorphic strategies or by differences in the ability to use the strategies , 2002 .

[33]  Raymond M. Klein,et al.  Of mice and men: Virtual Hebb—Williams mazes permit comparison of spatial learning across species , 2001, Cognitive, affective & behavioral neuroscience.