A modular approach for development of miniature detection systems

This paper describes development of the modular microfluidic components and their integration, directed toward the development of an electrochemical immunoassay-based bio-chemical detection system. The entire system consists of an array of fluid reservoirs, microfluidic valves & pump, a sampling/reaction chamber with integrated electromagnetic filterless bio-separator and a detection chamber comprising of the filterless bio-separator and an immunosensor. The magnetic beads are used to capture and detect the target toxins/molecules. This paper discusses the performance of the fluidic components and presents the preliminary results and packaging aspects of the 1st generation fluidic system. The effect of component size on system performance is also discussed.

[1]  R. Cattrall.  Chemical Sensors , 1997 .

[2]  M. Kohl,et al.  Stress-optimised shape memory microvalves , 1997, Proceedings IEEE The Tenth Annual International Workshop on Micro Electro Mechanical Systems. An Investigation of Micro Structures, Sensors, Actuators, Machines and Robots.

[3]  W. Heineman,et al.  Development of A Generic Microfluidic System for Electrochemical Immunoassay-Based Remote Bio/Chemical Sensors , 1998 .

[4]  Daniel J. Sadler,et al.  Prototype microvalve using a new magnetic microactuator , 1998, Photonics West - Micro and Nano Fabricated Electromechanical and Optical Components.

[5]  L. S. Kuhn.  Biosensors: Blockbuster or Bomb? Electrochemical Biosensors for Diabetes Monitoring , 1998, The Electrochemical Society Interface.

[6]  Y. Tai,et al.  A Parylene micro check valve , 1999 .

[7]  S. Bhansali,et al.  Development of Planar Microfluidic Systems Using Conventional and Low Temperature Assembling Schemes for Components , 1999, Micro-Electro-Mechanical Systems (MEMS).

[8]  S. Bhansali,et al.  An Integrated Reservoir for On-Chip Aqueous Storage in Microfluidic Systems , 1999, Micro-Electro-Mechanical Systems (MEMS).

[9]  Jin-Woo Choi,et al.  A new magnetic bead-based, filterless bio-separator with planar electromagnet surfaces for integrated bio-detection systems , 2000 .

[10]  S. Bhansali,et al.  A New Magnetically Actuated Microvalve for Liquid and Gas Control Applications , 2000 .

[11]  H. B. Halsall,et al.  Development and Characterization of Microfluidic Devices and Systems for Magnetic Bead-Based Biochemical Detection , 2001 .