Novel silicone hydrogel based on PDMS and PEGMA for contact lens application.

A silicone-based hydrogel was synthesized from poly(dimethylsiloxane) dialkanol (PDMS), isophorone diisocyanate (IPDI), 2-hydroxyethyl methacrylate (HEMA) and poly(ethylene glycol) methacrylate (PEGMA). The hydrophilicity of the resulting block copolymer was adjustable by manipulating the ratio of PDMS and PEGMA. The results showed that higher PEGMA content led to a lower water contact angle, higher water content, lower elastic modulus and higher glucose permeability. At a PEGMA content of 20%, the protein adsorption decreased to 23% and 18% for lysozyme and human serum albumin (HSA), respectively, of those of the control (PDMS-PU). This indicated that the PDMS-PU-PEGMA hydrogels exhibited an ability to resist protein adsorption. The oxygen permeability (Dk) was 92 barrers for the hydrogel with 20% PEGMA. Furthermore, these hydrogels were non-cytotoxic according to an in vitro L929 fibroblast assay. Overall, the results demonstrated that the PDMS-PU-PEGMA hydrogels exhibited not only relatively high oxygen permeability and relative optical transparency, but also hydrophilicity and anti-protein adsorption; therefore, they would be applicable as a contact lens material. Furthermore, this study demonstrated a new approach to controlling the performance of silicone hydrogels.

[1]  C. Jérôme,et al.  Improved performances of intraocular lenses by poly(ethylene glycol) chemical coatings. , 2007, Biomacromolecules.

[2]  B. McCarey,et al.  Modeling glucose distribution in the cornea. , 1990, Current eye research.

[3]  Jian Shen,et al.  Ozone-induced grafting phosphorylcholine polymer onto silicone film grafting 2-methacryloyloxyethyl phosphorylcholine onto silicone film to improve hemocompatibility , 2003 .

[4]  J. González-Méijome,et al.  Influence of environmental factors in the in vitro dehydration of hydrogel and silicone hydrogel contact lenses. , 2014, Journal of biomedical materials research. Part B, Applied biomaterials.

[5]  P. Morgan,et al.  Continuous wear silicone hydrogel contact lenses and microbial keratitis , 2004, Eye.

[6]  T. Simpson,et al.  Impact of Silicone Hydrogel Lenses and Solutions on Corneal Epithelial Permeability , 2013, Optometry and vision science : official publication of the American Academy of Optometry.

[7]  M. Brook,et al.  Surface properties of PEO–silicone composites: reducing protein adsorption , 2005, Journal of biomaterials science. Polymer edition.

[8]  A. P. Chapman,et al.  PEGylated antibodies and antibody fragments for improved therapy: a review. , 2002, Advanced drug delivery reviews.

[9]  C. Mayer,et al.  Synthesis and Characterization of Poly(ethylene glycol) Methacrylate Based Hydrogel Networks for Anti‐Biofouling Applications , 2013 .

[10]  F. Stapleton,et al.  Silicone Hydrogel Lens–Solution Interaction and Inflammation , 2013, Eye & contact lens.

[11]  E. Cohen,et al.  Episodes of Microbial Keratitis With Therapeutic Silicone Hydrogel Bandage Soft Contact Lenses , 2013, Eye & contact lens.

[12]  A. Graham,et al.  Effects of daily irrigation on corneal epithelial permeability and adverse events with silicone hydrogel contact lens continuous wear. , 2014, Investigative ophthalmology & visual science.

[13]  Y. Shu,et al.  Synthesis of polyurethane-imide (PU-imide) copolymers with different dianhydrides and their properties , 1999 .

[14]  Javier Pozuelo,et al.  Oxygen and ionic transport in hydrogel and silicone-hydrogel contact lens materials: An experimental and theoretical study , 2014 .

[15]  A. Chauhan,et al.  Feasibility of corneal drug delivery of cysteamine using vitamin E modified silicone hydrogel contact lenses. , 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[16]  B. Holden,et al.  Comparison of the Performance of 6- or 30-night Extended Wear Schedules with Silicone Hydrogel Lenses over 3 Years , 2004, Optometry and vision science : official publication of the American Academy of Optometry.

[17]  M. Senchyna,et al.  Lysozyme and Lipid Deposition on Silicone Hydrogel Contact Lens Materials , 2003, Eye & contact lens.

[18]  C. Tiu,et al.  Effect of crosslinking density on the physical properties of interpenetrating polymer networks of polyurethane and 2-hydroxyethyl methacrylate-teminated polyurethane , 1998 .

[19]  C. Lin,et al.  Hemocompatibility and cytocompatibility of styrenesulfonate-grafted PDMS-polyurethane-HEMA hydrogel. , 2009, Colloids and surfaces. B, Biointerfaces.

[20]  G. Saleh,et al.  Applanation tonometry in silicone hydrogel contact lens wearers. , 2004, Contact lens & anterior eye : the journal of the British Contact Lens Association.

[21]  K. Neoh,et al.  Cellular response to magnetic nanoparticles "PEGylated" via surface-initiated atom transfer radical polymerization. , 2006, Biomacromolecules.

[22]  C. Lin,et al.  Fabrication and characterization of ophthalmically compatible hydrogels composed of poly(dimethyl siloxane-urethane)/Pluronic F127. , 2009, Colloids and Surfaces B: Biointerfaces.

[23]  J. Vogt,et al.  Soft contact lens polymers: an evolution. , 2001, Biomaterials.

[24]  Lyndon Jones,et al.  Hyaluronic acid containing hydrogels for the reduction of protein adsorption. , 2008, Biomaterials.

[25]  A. K. Bajpai,et al.  Blood protein adsorption onto a polymeric biomaterial of polyethylene glycol and poly[(2-hydroxyethyl methacrylate)-co-acrylonitrile] and evaluation of in vitro blood compatibility , 2005 .

[26]  B. Holden,et al.  Superior Epithelial Arcuate Lesions with Soft Contact Lens Wear , 2001, Optometry and vision science : official publication of the American Academy of Optometry.

[27]  B. Holden,et al.  Changes in Myopia with Low-Dk Hydrogel and High-Dk Silicone Hydrogel Extended Wear , 2004, Optometry and vision science : official publication of the American Academy of Optometry.

[28]  E. Papas,et al.  Corneal and conjunctival sensory function: the impact on ocular surface sensitivity of change from low to high oxygen transmissibility contact lenses. , 2012, Investigative ophthalmology & visual science.

[29]  M. Refojo,et al.  Refractive index and equilibrium water content of conventional and silicone hydrogel contact lenses , 2006, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[30]  R. Dey,et al.  Synthesis, characterization, and blood compatibility of polyamidoamines copolymers. , 2003, Biomaterials.

[31]  H. Sheardown,et al.  Immobilized hyaluronic acid containing model silicone hydrogels reduce protein adsorption , 2008, Journal of biomaterials science. Polymer edition.

[32]  J. Turner,et al.  Morphology of PDMS-PMAA IPN membranes , 2003 .

[33]  Young Ha Kim,et al.  Enhanced blood compatibility of polymers grafted by sulfonated PEO via a negative cilia concept. , 2003, Biomaterials.

[34]  J. Prausnitz,et al.  A single-lens polarographic measurement of oxygen permeability (Dk) for hypertransmissible soft contact lenses. , 2007, Biomaterials.

[35]  J. West-Mays,et al.  EGF-grafted PDMS surfaces in artificial cornea applications. , 2005, Biomaterials.

[36]  T. V. van Kooten,et al.  Physicochemical and biological evaluation of poly(ethylene glycol) methacrylate grafted onto poly(dimethyl siloxane) surfaces for prosthetic devices. , 2013, Colloids and surfaces. B, Biointerfaces.

[37]  H. Sheardown,et al.  Dendrimer crosslinked collagen as a corneal tissue engineering scaffold: mechanical properties and corneal epithelial cell interactions. , 2006, Biomaterials.

[38]  Anuj Chauhan,et al.  Extended delivery of ophthalmic drugs by silicone hydrogel contact lenses. , 2008, Biomaterials.

[39]  Yung Chang,et al.  Low-biofouling membranes prepared by liquid-induced phase separation of the PVDF/polystyrene-b-poly (ethylene glycol) methacrylate blend , 2014 .

[40]  H. Sheardown,et al.  Glucose permeable poly (dimethyl siloxane) poly (N-isopropyl acrylamide) interpenetrating networks as ophthalmic biomaterials. , 2005, Biomaterials.

[41]  L. Keay,et al.  Mucin Balls with Wear of Conventional and Silicone Hydrogel Contact Lenses , 2003, Optometry and vision science : official publication of the American Academy of Optometry.

[42]  Xuan Mao,et al.  Preparation of bioactive nano-hydroxyapatite coating for artificial cornea , 2007 .

[43]  J. Mehta,et al.  Intraocular lens as a drug delivery reservoir , 2013, Current opinion in ophthalmology.

[44]  C. O’Donnell.  Continuous wear contact lenses , 2003 .

[45]  H. Mirzadeh,et al.  Properties of poly(dimethylsiloxane)/hydrogel multicomponent systems , 2003 .

[46]  P. Morgan,et al.  Oxygen Permeability and Water Content of Silicone Hydrogel Contact Lens Materials , 2007, Optometry and vision science : official publication of the American Academy of Optometry.

[47]  H. Mirzadeh,et al.  Modification of polysiloxane polymers for biomedical applications: a review , 2001 .

[48]  D. Ammon,et al.  The relationship between contact lens surface charge and in-vitro protein deposition levels. , 2001, Biomaterials.

[49]  D. Meadows,et al.  Dynamic wettability properties of a soft contact lens hydrogel. , 2005, Colloids and surfaces. B, Biointerfaces.

[50]  Susan C. Roberts,et al.  Effect of mammalian cell culture medium on the gelation properties of Pluronic F127. , 2002, Biomaterials.

[51]  H. Mirzadeh,et al.  Hydrophilic interpenetrating polymer networks of poly(dimethyl siloxane) (PDMS) as biomaterial for cochlear implants , 2006, Journal of Biomaterials Science. Polymer Edition.

[52]  K. Neoh,et al.  Surface modification of polyaniline film by grafting of poly(ethylene glycol) for reduction in protein adsorption and platelet adhesion , 2000 .

[53]  Zhi‐Kang Xu,et al.  Improvement of the surface biocompatibility of silicone intraocular lens by the plasma-induced tethering of phospholipid moieties. , 2006, Journal of biomedical materials research. Part A.

[54]  P. Morgan,et al.  Ocular physiology and comfort in neophyte subjects fitted with daily disposable silicone hydrogel contact lenses. , 2013, Contact lens & anterior eye : the journal of the British Contact Lens Association.

[55]  W. L. Chang.  Decomposition Behavior of Polyurethanes via Mathematical Simulation , 1994 .

[56]  K. Dumbleton.  Noninflammatory Silicone Hydrogel Contact Lens Complications , 2003, Eye & contact lens.

[57]  V. Migonney,et al.  Surface modification of silicone intraocular implants to inhibit cell proliferation. , 2005, Biomacromolecules.

[58]  M. Guillon,et al.  Use of silicone hydrogel material for daily wear. , 2007, Contact lens & anterior eye : the journal of the British Contact Lens Association.

[59]  L. Szczotka-Flynn,et al.  Corneal Inflammatory Events with Daily Silicone Hydrogel Lens Wear , 2014, Optometry and vision science : official publication of the American Academy of Optometry.