Policy-relevant differences between secondhand and thirdhand smoke: strengthening protections from involuntary exposure to tobacco smoke pollutants

Starting in the 1970s, individuals, businesses and the public have increasingly benefited from policies prohibiting smoking indoors, saving thousands of lives and billions of dollars in healthcare expenditures. Smokefree policies to protect against secondhand smoke exposure, however, do not fully protect the public from the persistent and toxic chemical residues from tobacco smoke (also known as thirdhand smoke) that linger in indoor environments for years after smoking stops. Nor do these policies address the economic costs that individuals, businesses and the public bear in their attempts to remediate this toxic residue. We discuss policy-relevant differences between secondhand smoke and thirdhand smoke exposure: persistent pollutant reservoirs, pollutant transport, routes of exposure, the time gap between initial cause and effect, and remediation and disposal. We examine four policy considerations to better protect the public from involuntary exposure to tobacco smoke pollutants from all sources. We call for (a) redefining smokefree as free of tobacco smoke pollutants from secondhand and thirdhand smoke; (b) eliminating exemptions to comprehensive smoking bans; (c) identifying indoor environments with significant thirdhand smoke reservoirs; and (d) remediating thirdhand smoke. We use the case of California as an example of how secondhand smoke-protective laws may be strengthened to encompass thirdhand smoke protections. The health risks and economic costs of thirdhand smoke require that smokefree policies, environmental protections, real estate and rental disclosure policies, tenant protections, and consumer protection laws be strengthened to ensure that the public is fully protected from and informed about the risks of thirdhand smoke exposure.

[1]  D. Camenga,et al.  Protecting Children and Adolescents From Tobacco and Nicotine. , 2023, Pediatrics.

[2]  P. Talbot,et al.  Exposure, Retention, Exhalation, Symptoms, and Environmental Accumulation of Chemicals During JUUL Vaping. , 2023, Chemical research in toxicology.

[3]  A. Snijders,et al.  Thirdhand tobacco smoke exposure increases the genetic background-dependent risk of pan-tumor development in Collaborative Cross mice. , 2023, Environment international.

[4]  G. Matt,et al.  Distinguishing Exposure to Secondhand and Thirdhand Tobacco Smoke among U.S. Children Using Machine Learning: NHANES 2013-2016. , 2023, Environmental science & technology.

[5]  Jun Yu Li,et al.  Dermal thirdhand smoke exposure induces oxidative damage, initiates skin inflammatory markers, and adversely alters the human plasma proteome , 2022, EBioMedicine.

[6]  G. Matt,et al.  Hand nicotine as an independent marker of thirdhand smoke pollution in children’s environments , 2022, The Science of the total environment.

[7]  A. Snijders,et al.  Thirdhand Exposures to Tobacco-Specific Nitrosamines through Inhalation, Dust Ingestion, Dermal Uptake, and Epidermal Chemistry. , 2022, Environmental science & technology.

[8]  Myung-Bae Park,et al.  Evaluation of Thirdhand Smoke Exposure after Short Visits to Public Facilities (Noraebang and Internet Cafés): A Prospective Cohort Study , 2022, Toxics.

[9]  A. Sarker,et al.  Tobacco-specific nitrosamine 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal (NNA) causes DNA damage and impaired replication/transcription in human lung cells , 2022, PloS one.

[10]  F. Khasawneh,et al.  Exposure of Mice to Thirdhand Smoke Modulates In Vitro and In Vivo Platelet Responses , 2022, International journal of molecular sciences.

[11]  F. Liu,et al.  Association between involuntary smoking and risk of cervical cancer in Chinese female never smokers: A prospective cohort study. , 2022, Environmental research.

[12]  R. Proctor,et al.  Prohibition no, abolition yes! Rethinking how we talk about ending the cigarette epidemic , 2022, Tobacco Control.

[13]  G. Matt,et al.  Prevalence and Income-Related Disparities in Thirdhand Smoke Exposure to Children , 2022, JAMA network open.

[14]  F. Wania,et al.  Thirdhand smoke from tobacco, e-cigarettes, cannabis, methamphetamine and cocaine: Partitioning, reactive fate, and human exposure in indoor environments. , 2021, Environment international.

[15]  G. Matt,et al.  When Hotel Guests Complain About Tobacco, Electronic Cigarettes, and Cannabis: Lessons for Implementing Smoking Bans , 2022, Tobacco use insights.

[16]  G. Matt,et al.  Handwashing Results in Incomplete Nicotine Removal from Fingers of Individuals who Smoke: A Randomized Controlled Experiment , 2021, American Journal of Perinatology.

[17]  G. Matt,et al.  Differential associations of hand nicotine and urinary cotinine with children's exposure to tobacco smoke and clinical outcomes. , 2021, Environmental research.

[18]  A. Snijders,et al.  Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice , 2021, Scientific Reports.

[19]  G. Matt,et al.  Hand Nicotine and Cotinine In Children Exposed to Cigars: A Pilot Study. , 2021, Tobacco regulatory science.

[20]  A. Olshen,et al.  In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system , 2021, Clinical science.

[21]  R. Harrison,et al.  Ubiquitous atmospheric contamination by tobacco smoke: Nicotine and a new marker for tobacco smoke-derived particulate matter, nicotelline , 2021, Environment international.

[22]  E. Gakidou,et al.  The effects of tobacco control policies on global smoking prevalence , 2021, Nature Medicine.

[23]  H. Destaillats,et al.  Chemical changes in thirdhand smoke associated with remediation using an ozone generator. , 2020, Environmental research.

[24]  J. Abbatt,et al.  Heterogeneous Ozonolysis of Tetrahydrocannabinol: Implications for Thirdhand Cannabis Smoke. , 2020, Environmental science & technology.

[25]  G. Matt,et al.  Tobacco smoke is a likely source of lead and cadmium in settled house dust , 2020, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[26]  G. Matt,et al.  Thirdhand smoke contamination and infant nicotine exposure in a neonatal intensive care unit: An observational study. , 2020, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[27]  G. Matt,et al.  Remediating Thirdhand Smoke Pollution in Multiunit Housing: Temporary Reductions and the Challenges of Persistent Reservoirs. , 2020, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[28]  Patricia A. McDaniel,et al.  California advocates’ perspectives on challenges and risks of advancing the tobacco endgame , 2020, Journal of Public Health Policy.

[29]  A. Snijders,et al.  Thirdhand smoke exposure causes replication stress and impaired transcription in human lung cells , 2020, Environmental and molecular mutagenesis.

[30]  G. Matt,et al.  Persistent tobacco smoke residue in multiunit housing: Legacy of permissive indoor smoking policies and challenges in the implementation of smoking bans , 2020, Preventive medicine reports.

[31]  Jonathan Williams,et al.  Human transport of thirdhand tobacco smoke: A prominent source of hazardous air pollutants into indoor nonsmoking environments , 2020, Science Advances.

[32]  P. Talbot,et al.  Experimental Acute Exposure to Thirdhand Smoke and Changes in the Human Nasal Epithelial Transcriptome , 2019, JAMA network open.

[33]  G. Matt,et al.  Medical staff contributions to thirdhand smoke contamination in a neonatal intensive care unit , 2019, Tobacco induced diseases.

[34]  Dongmug Kang,et al.  Public Facility Utility and Third-Hand Smoking Exposure without First and Second-Hand Smoking According to Urinary Cotinine Level , 2019, International journal of environmental research and public health.

[35]  A. Balaguer,et al.  Update on thirdhand smoke: A comprehensive systematic review , 2018, Environmental research.

[36]  Adam Whitlatch,et al.  Thirdhand Smoke at Philip Morris. , 2018, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[37]  P. DeCarlo,et al.  Thirdhand smoke uptake to aerosol particles in the indoor environment , 2018, Science Advances.

[38]  G. Clausen,et al.  Dermal uptake of nicotine from air and clothing: Experimental verification , 2018, Indoor air.

[39]  G. Matt,et al.  A Casino goes smoke free: a longitudinal study of secondhand and thirdhand smoke pollution and exposure , 2018, Tobacco Control.

[40]  G. Matt,et al.  Hotel smoking policies and their implementation: a survey of California hotel managers , 2017, Tobacco induced diseases.

[41]  K. Wilson,et al.  Tobacco-Smoke Incursions and Satisfaction Among Residents With Children in Multiunit Housing, United States, 2013 , 2017, Public health reports.

[42]  A. Snijders,et al.  Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models , 2017, International journal of molecular sciences.

[43]  H. Solo-Gabriele,et al.  A Review of the Field on Children’s Exposure to Environmental Contaminants: A Risk Assessment Approach , 2017, International journal of environmental research and public health.

[44]  G. Clausen,et al.  Measurements of dermal uptake of nicotine directly from air and clothing , 2017, Indoor air.

[45]  A. Snijders,et al.  Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice , 2017, Scientific Reports.

[46]  J. Samet,et al.  Thirdhand Smoke: New Evidence, Challenges, and Future Directions. , 2017, Chemical research in toxicology.

[47]  M. Carr,et al.  Environmental Tobacco Smoke: Public Perception of Risks of Exposing Children to Second- and Third-Hand Tobacco Smoke. , 2016, Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners.

[48]  G. Matt,et al.  When smokers quit: exposure to nicotine and carcinogens persists from thirdhand smoke pollution , 2016, Tobacco Control.

[49]  J. Mao,et al.  Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing. , 2016, Clinical science.

[50]  Yankai Xia,et al.  Corrigendum: Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke , 2016, Scientific Reports.

[51]  I. Cozzarelli,et al.  Landfill leachate as a mirror of today's disposable society: Pharmaceuticals and other contaminants of emerging concern in final leachate from landfills in the conterminous United States , 2016, Environmental toxicology and chemistry.

[52]  P. Talbot,et al.  Thirdhand smoke: Chemical dynamics, cytotoxicity, and genotoxicity in outdoor and indoor environments. , 2016, Toxicology in vitro : an international journal published in association with BIBRA.

[53]  P. Talbot,et al.  Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation. , 2016, Toxicological sciences : an official journal of the Society of Toxicology.

[54]  Matthew Desmond,et al.  Housing and Employment Insecurity among the Working Poor , 2016 .

[55]  N. Benowitz,et al.  Thirdhand smoke contamination in hospital settings: assessing exposure risk for vulnerable paediatric patients , 2015, Tobacco Control.

[56]  Yankai Xia,et al.  Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke , 2015, Scientific Reports.

[57]  J. Samet,et al.  The Challenges of Limiting Exposure to THS in Vulnerable Populations , 2015, Current Environmental Health Reports.

[58]  T. Novotny The Tobacco Endgame: Is It Possible? , 2015, PLoS medicine.

[59]  Hugo Destaillats,et al.  Inhalable constituents of thirdhand tobacco smoke: chemical characterization and health impact considerations. , 2014, Environmental science & technology.

[60]  P. Talbot,et al.  Thirdhand Cigarette Smoke: Factors Affecting Exposure and Remediation , 2014, PloS one.

[61]  A. Lewis,et al.  Exposure to nitrosamines in thirdhand tobacco smoke increases cancer risk in non-smokers. , 2014, Environment international.

[62]  I. Cozzarelli,et al.  Contaminants of emerging concern in fresh leachate from landfills in the conterminous United States. , 2014, Environmental science. Processes & impacts.

[63]  Julia G. Lyubovitsky,et al.  Cigarette Smoke Toxins Deposited on Surfaces: Implications for Human Health , 2014, PloS one.

[64]  Eunha Hoh,et al.  Wipe sampling for nicotine as a marker of thirdhand tobacco smoke contamination on surfaces in homes, cars, and hotels. , 2013, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[65]  P. Jacob,et al.  Thirdhand smoke causes DNA damage in human cells. , 2013, Mutagenesis.

[66]  P. Pirie,et al.  Individual, social, and environmental factors associated with support for smoke-free housing policies among subsidized multiunit housing tenants. , 2013, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[67]  J. Balmes,et al.  Thirdhand cigarette smoke in an experimental chamber: evidence of surface deposition of nicotine, nitrosamines and polycyclic aromatic hydrocarbons and de novo formation of NNK , 2013, Tobacco Control.

[68]  G. Matt,et al.  Thirdhand smoke and exposure in California hotels: non-smoking rooms fail to protect non-smoking hotel guests from tobacco smoke exposure , 2013, Tobacco Control.

[69]  P. Pirie,et al.  Associations between self-reported in-home smoking behaviours and surface nicotine concentrations in multiunit subsidised housing , 2012, Tobacco Control.

[70]  Hye‐Ryun Kang,et al.  Association between parental smoking behavior and children's respiratory morbidity: 5‐year study in an urban city of South Korea , 2012, Pediatric pulmonology.

[71]  G. Matt,et al.  Environmental tobacco smoke as a source of polycyclic aromatic hydrocarbons in settled household dust. , 2012, Environmental science & technology.

[72]  G. Matt,et al.  Towards smoke-free rental cars: an evaluation of voluntary smoking restrictions in California , 2012, Tobacco Control.

[73]  R. Kaplan,et al.  Estimates of smoking-related property costs in California multiunit housing. , 2012, American journal of public health.

[74]  Kurt Straif,et al.  Preventable exposures associated with human cancers. , 2011, Journal of the National Cancer Institute.

[75]  J. Samet,et al.  Thirdhand Tobacco Smoke: Emerging Evidence and Arguments for a Multidisciplinary Research Agenda , 2011, Environmental health perspectives.

[76]  K. Wilson,et al.  Tobacco-Smoke Exposure in Children Who Live in Multiunit Housing , 2011, Pediatrics.

[77]  G. Matt,et al.  When smokers move out and non-smokers move in: residential thirdhand smoke pollution and exposure , 2010, Tobacco Control.

[78]  G. Matt,et al.  Residual tobacco smoke in used cars: futile efforts and persistent pollutants. , 2010, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[79]  R. Malone Imagining things otherwise: new endgame ideas for tobacco control , 2010, Tobacco Control.

[80]  J. Pankow,et al.  Formation of carcinogens indoors by surface-mediated reactions of nicotine with nitrous acid, leading to potential thirdhand smoke hazards , 2010, Proceedings of the National Academy of Sciences.

[81]  H. Destaillats,et al.  Rapid and sensitive gas chromatography-ion-trap tandem mass spectrometry method for the determination of tobacco-specific N-nitrosamines in secondhand smoke. , 2009, Journal of chromatography. A.

[82]  D. Kolpin,et al.  Waste-Indicator and Pharmaceutical Compounds in Landfill-Leachate-Affected Ground Water near Elkhart, Indiana, 2000–2002 , 2009, Bulletin of environmental contamination and toxicology.

[83]  G. Matt,et al.  Beliefs About the Health Effects of “Thirdhand” Smoke and Home Smoking Bans , 2009, Pediatrics.

[84]  T. Perfetti,et al.  The Chemical Components of Tobacco and Tobacco Smoke , 2008 .

[85]  G. Matt,et al.  Residual tobacco smoke pollution in used cars for sale: air, dust, and surfaces. , 2008, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[86]  T. Poiger,et al.  Nicotine derivatives in wastewater and surface waters: application as chemical markers for domestic wastewater. , 2008, Environmental science & technology.

[87]  S. Glantz,et al.  Effect of the California Tobacco Control Program on Personal Health Care Expenditures , 2008, PLoS medicine.

[88]  S. Glantz,et al.  Concentrations of the Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Sidestream Cigarette Smoke Increase after Release into Indoor Air: Results from Unpublished Tobacco Industry Research , 2007, Cancer Epidemiology Biomarkers & Prevention.

[89]  Ipcs,et al.  Principles for evaluating health risks in children associated with exposure to chemicals , 2006 .

[90]  S. Glantz,et al.  Sidestream cigarette smoke toxicity increases with aging and exposure duration , 2006, Tobacco Control.

[91]  S. Glantz,et al.  smoke sidestream smoke : more toxic than mainstream , 2005 .

[92]  R. Etzel,et al.  Children's behavior and physiology and how it affects exposure to environmental contaminants. , 2004, Pediatrics.

[93]  G. Matt,et al.  Households contaminated by environmental tobacco smoke: sources of infant exposures , 2004, Tobacco Control.

[94]  A. Hodgson,et al.  Gas-phase organics in environmental tobacco smoke: 2. Exposure-relevant emission factors and indirect exposures from habitual smoking , 2003 .

[95]  Elisabeth L. Hawley,et al.  Gas-phase organics in environmental tobacco smoke. 1. Effects of smoking rate, ventilation, and furnishing level on emission factors. , 2002, Environmental science & technology.

[96]  J. Daisey Tracers for assessing exposure to environmental tobacco smoke: what are they tracing? , 1999, Environmental health perspectives.

[97]  G. Matt,et al.  Cotton pillows: A novel field method for assessment of thirdhand smoke pollution , 2019, Environmental research.

[98]  Yankai Xia,et al.  [A investigation of thirdhand smoke pollution in 3 types of places of Nanjing, 2014]. , 2015, Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].

[99]  S. Hecht,et al.  Thirdhand tobacco smoke: a tobacco-specific lung carcinogen on surfaces in smokers' homes. , 2014, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[100]  Office on Smoking How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General , 2010 .

[101]  R. G. Lewis,et al.  Monitoring and reducing exposure of infants to pollutants in house dust. , 2009, Reviews of environmental contamination and toxicology.

[102]  Michael Marmot,et al.  Closing the gap in a generation: health equity through action on the social determinants of health. Final report of the Commission on Social Determinants of Health. , 2008 .

[103]  D. Spath Office of Environmental Health Hazard Assessment , 2000 .

[104]  U. Epa Guidelines for carcinogen risk assessment , 1986 .

[105]  J. Higginson,et al.  International Agency for Research on Cancer. , 1968, WHO chronicle.