Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasis.

[1]  Russell E. Lewis,et al.  Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high‐risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation , 2007, Cancer.

[2]  B. Spellberg,et al.  The iron chelator deferasirox protects mice from mucormycosis through iron starvation. , 2007, The Journal of clinical investigation.

[3]  Ken Haynes,et al.  Distinct Roles for Intra- and Extracellular Siderophores during Aspergillus fumigatus Infection , 2007, PLoS pathogens.

[4]  G. Weiss,et al.  The co‐ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimurium , 2007, Cellular microbiology.

[5]  M. Hentze,et al.  Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1 , 2007, Nature Medicine.

[6]  R. Appelberg.  Macrophage nutriprive antimicrobial mechanisms , 2006, Journal of leukocyte biology.

[7]  D. Underhill,et al.  Dectin-1 and TLRs Permit Macrophages to Distinguish between Different Aspergillus fumigatus Cellular States1 , 2006, The Journal of Immunology.

[8]  G. Weiss,et al.  Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis , 2005, Journal of cellular physiology.

[9]  G. Weiss,et al.  The Macrophage: A Cellular Factory at the Interphase Between Iron and Immunity for the Control of Infections , 2005, Biometals.

[10]  S. Kaufmann,et al.  Iron and microbial infection , 2005, Nature Reviews Microbiology.

[11]  Ken Haynes,et al.  Siderophore Biosynthesis But Not Reductive Iron Assimilation Is Essential for Aspergillus fumigatus Virulence , 2004, The Journal of experimental medicine.

[12]  T. Meklin,et al.  Exposure to Aspergillus fumigatus spores induces chemokine expression in mouse macrophages. , 2004, Toxicology.

[13]  M. Moore,et al.  Survival of Aspergillus fumigatus in Serum Involves Removal of Iron from Transferrin: the Role of Siderophores , 2004, Infection and Immunity.

[14]  E. A. Leibold,et al.  Effects of iron regulatory protein regulation on iron homeostasis during hypoxia. , 2003, Blood.

[15]  A. Kaser,et al.  Pathways for the regulation of interferon‐γ‐inducible genes by iron in human monocytic cells , 2003 .

[16]  Hubertus Haas,et al.  The siderophore system is essential for viability of Aspergillus nidulans: functional analysis of two genes encoding l‐ornithine N 5‐monooxygenase (sidA) and a non‐ribosomal peptide synthetase (sidC) , 2003, Molecular microbiology.

[17]  M. Prevost,et al.  Killing of Aspergillus fumigatus by Alveolar Macrophages Is Mediated by Reactive Oxidant Intermediates , 2003, Infection and Immunity.

[18]  H. Haas.  Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage , 2003, Applied Microbiology and Biotechnology.

[19]  G. Weiss,et al.  Cytokine Mediated Regulation of Iron Transport in Human Monocytic Cells , 2003 .

[20]  A. Kaser,et al.  Pathways for the regulation of interferon-gamma-inducible genes by iron in human monocytic cells. , 2003, Journal of leukocyte biology.

[21]  Thomas Patterson,et al.  Aspergillosis: Pathogenesis, clinical manifestations, and therapy , 2002 .

[22]  M. Momany.  Polarity in filamentous fungi: establishment, maintenance and new axes. , 2002, Current opinion in microbiology.

[23]  G. Weiss.  Iron and immunity: a double‐edged sword , 2002, European journal of clinical investigation.

[24]  G. Winkelmann.  Microbial siderophore-mediated transport. , 2001, Biochemical Society transactions.

[25]  S. Oppenheimer.  Iron and its relation to immunity and infectious disease. , 2001, The Journal of nutrition.

[26]  S. Abboud,et al.  A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism* , 2000, The Journal of Biological Chemistry.

[27]  A. Brownlie,et al.  Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter , 2000, Nature.

[28]  R J Simpson,et al.  A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. , 2000, Molecular cell.

[29]  L. Xu,et al.  Positional cloning. , 2000, Methods in molecular biology.

[30]  G. Weiss,et al.  Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression. , 1999, Journal of immunology.

[31]  E. Weinberg.  The Role of Iron In Protozoan and Fungal Infectious Diseases , 1999, The Journal of eukaryotic microbiology.

[32]  E. Weinberg,et al.  Iron loading and disease surveillance. , 1999, Emerging infectious diseases.

[33]  J. Latgé,et al.  Aspergillus fumigatus and Aspergillosis , 1999, Clinical Microbiology Reviews.

[34]  T. Standiford,et al.  Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis. , 1999, Journal of immunology.

[35]  M. Schneemann,et al.  Host defense mechanism in Aspergillus fumigatus infections. , 1999, Contributions to microbiology.

[36]  T. Walsh,et al.  Tumor necrosis factor alpha enhances antifungal activities of polymorphonuclear and mononuclear phagocytes against Aspergillus fumigatus. , 1998, Infection and immunity.

[37]  D. Conte,et al.  Response of monocyte iron regulatory protein activity to inflammation: abnormal behavior in genetic hemochromatosis. , 1998, Blood.

[38]  J. Paulauskis,et al.  Concentration- and time-dependent upregulation and release of the cytokines MIP-2, KC, TNF, and MIP-1alpha in rat alveolar macrophages by fungal spores implicated in airway inflammation. , 1998, American journal of respiratory cell and molecular biology.

[39]  S. Leong,et al.  Molecular biology of iron transport in fungi. , 1998, Metal ions in biological systems.

[40]  G. Melillo,et al.  Functional Requirement of the Hypoxia-responsive Element in the Activation of the Inducible Nitric Oxide Synthase Promoter by the Iron Chelator Desferrioxamine* , 1997, The Journal of Biological Chemistry.

[41]  M. Hentze,et al.  Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways , 1996, Molecular and cellular biology.

[42]  M. Hentze,et al.  Rapid responses to oxidative stress mediated by iron regulatory protein. , 1995, The EMBO journal.

[43]  M. Hentze,et al.  Iron regulates nitric oxide synthase activity by controlling nuclear transcription , 1994, The Journal of experimental medicine.

[44]  G Werner-Felmayer,et al.  Translational regulation via iron‐responsive elements by the nitric oxide/NO‐synthase pathway. , 1993, The EMBO journal.

[45]  J. Drapier,et al.  Biosynthesis of nitric oxide activates iron regulatory factor in macrophages. , 1993, The EMBO journal.

[46]  E. Werner,et al.  Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1. , 1992, Experimental hematology.

[47]  H. Munro,et al.  Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[48]  N. Horowitz,et al.  Cellular and extracellular siderophores of Aspergillus nidulans and Penicillium chrysogenum , 1981, Molecular and cellular biology.