First identification of Ewing's sarcoma‐derived extracellular vesicles and exploration of their biological and potential diagnostic implications

Exosomes are small RNA‐ and protein‐containing extracellular vesicles (EVs) that are thought to mediate hetero‐ and homotypic intercellular communication between normal and malignant cells. Tumour‐derived exosomes are believed to promote re‐programming of the tumour‐associated stroma to favour tumour growth and metastasis. Currently, exosomes have been intensively studied in carcinomas. However, little is known about their existence and possible role in sarcomas.

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