Intratumor genomic heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastases

[1]  J. Peterse,et al.  Breast cancer metastasis: markers and models , 2005, Nature Reviews Cancer.

[2]  J. Jónasson,et al.  Cytogenetic changes in nonmalignant breast tissue , 2004, Genes, chromosomes & cancer.

[3]  R. Lothe,et al.  Assessment of clonal relationships in ipsilateral and bilateral multiple breast carcinomas by comparative genomic hybridisation and hierarchical clustering analysis , 2004, British Journal of Cancer.

[4]  C. R. Leemans,et al.  Using tissue adjacent to carcinoma as a normal control: an obvious but questionable practice , 2004, The Journal of pathology.

[5]  Ruud H. Brakenhoff,et al.  Dissecting the metastatic cascade , 2004, Nature Reviews Cancer.

[6]  C. R. Leemans,et al.  A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. , 2003, Cancer research.

[7]  D. Goudie,et al.  Karyotypic aberrations of chromosomes 16 and 17 are related to survival in patients with breast cancer , 2002, The British journal of surgery.

[8]  M. Odero,et al.  Genomic imbalances detected by comparative genomic hybridization are prognostic markers in invasive ductal breast carcinomas , 2002, Histopathology.

[9]  H. Moch,et al.  DNA sequence losses on chromosomes 11p and 18q are associated with clinical outcome in lymph node-negative ductal breast cancer. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[10]  R. Lothe,et al.  Genome profiling of breast cancer cells selected against in vitro shows copy number changes , 2002, Genes, chromosomes & cancer.

[11]  S. Dairkee,et al.  Increased risk of local recurrence is associated with allelic loss in normal lobules of breast cancer patients. , 2002, Cancer research.

[12]  M. Teixeira,et al.  Cytogenetic clues to breast carcinogenesis , 2002, Genes, chromosomes & cancer.

[13]  J. Nährig,et al.  Chromosomal Imbalances are Associated with Metastasis-Free Survival in Breast Cancer Patients , 2002, Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology.

[14]  I. Tomlinson Mutations in normal breast tissue and breast tumours , 2001, Breast Cancer Research.

[15]  N. Bengtsson,et al.  Intratumoral Variations in DNA Ploidy and S-Phase Fraction in Human Breast Cancer , 2001, Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology.

[16]  S. Devries,et al.  Chromosomal alterations in ductal carcinomas in situ and their in situ recurrences. , 2000, Journal of the National Cancer Institute.

[17]  M. Stratton,et al.  Genetic alterations in ‘normal’ luminal and myoepithelial cells of the breast , 1999, The Journal of pathology.

[18]  H. Höfler,et al.  Intratumoral heterogeneity in breast carcinoma revealed by laser-microdissection and comparative genomic hybridization. , 1999, Cancer genetics and cytogenetics.

[19]  P. V. van Diest,et al.  Genetic analysis of 53 lymph node‐negative breast carcinomas by CGH and relation to clinical, pathological, morphometric, and DNA cytometric prognostic factors , 1998, The Journal of pathology.

[20]  F. Mitelman,et al.  Cytogenetic comparison of primary tumors and lymph node metastases in breast cancer patients , 1998, Genes, chromosomes & cancer.

[21]  C. Lundsteen,et al.  Detection of chromosomal gains and losses in comparative genomic hybridization analysis based on standard reference intervals. , 1998, Cytometry.

[22]  Takafumi Nishizaki,et al.  Genetic alterations in primary breast cancers and their metastases: Direct comparison using modified comparative genomic hybridization , 1997, Genes, chromosomes & cancer.

[23]  A. Schäffer,et al.  Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer. , 1997, Cancer research.

[24]  A. Thor,et al.  Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas , 1996, Science.

[25]  J. Andersen,et al.  Karyotypic comparisons of multiple tumorous and macroscopically normal surrounding tissue samples from patients with breast cancer. , 1996, Cancer research.

[26]  S. Hilsenbeck,et al.  Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer. , 1995, The American journal of pathology.

[27]  F. Mitelman,et al.  Clonal heterogeneity in breast cancer: Karyotypic comparisons of multiple intra—and extra—tumorous samples from 3 patients , 1995, International journal of cancer.

[28]  M. Durm,et al.  Intratumor variability in prognostic indicators may be the cause of conflicting estimates of patient survival and response to therapy. , 1994, Cancer research.

[29]  J Piper,et al.  Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors , 1994, Genes, chromosomes & cancer.

[30]  B. Ljung,et al.  Heterogeneity for allelic loss in human breast cancer. , 1992, Journal of the National Cancer Institute.

[31]  F. Mitelman,et al.  Genetic convergence and divergence in tumor progression. , 1988, Cancer research.

[32]  L. Sobin,et al.  Histological Typing of Breast Tumors 1 , 1982 .

[33]  P. Nowell The clonal evolution of tumor cell populations. , 1976, Science.

[34]  R. Lothe,et al.  Evaluation of breast cancer polyclonality by combined chromosome banding and comparative genomic hybridization analysis. , 2001, Neoplasia.

[35]  C. Cornelisse,et al.  Flow cytometric analysis of DNA stemline heterogeneity in primary and metastatic breast cancer. , 1991, Cytometry.

[36]  Iscn International System for Human Cytogenetic Nomenclature , 1978 .